T-bet in disease. (Q37891668)

PubMed publication ID

24 August 2017

1 reference

title

T-bet in disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

2

Laurie H Glimcher

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

20 June 2011

1 reference

PubMed publication ID

24 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

page(s)

597-606

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

A novel transcription factor, T-bet, directs Th1 lineage commitment

13 May 2020

cites work

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

21 January 2018

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Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

21 January 2018

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

21 January 2018

1 reference

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

21 January 2018

1 reference

T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

21 January 2018

1 reference

STAT1-Activating Cytokines Limit Th17 Responses through Both T-bet–Dependent and –Independent Mechanisms

21 January 2018

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T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function

21 January 2018

1 reference

Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

21 January 2018

1 reference

Antigen-driven effector CD8 T cell function regulated by T-bet

21 January 2018

1 reference

T-bet regulates IgG class switching and pathogenic autoantibody production

21 January 2018

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T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells

21 January 2018

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

21 January 2018

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Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

21 January 2018

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Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.

21 January 2018

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Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases

21 January 2018

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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

21 January 2018

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T-bet is required for optimal proinflammatory CD4 T-cell trafficking.

21 January 2018

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Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production

21 January 2018

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

21 January 2018

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T-box transcription-factor-deficient mice display increased joint pathology and failure of infection control during staphylococcal arthritis

21 January 2018

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Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection.

21 January 2018

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The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

21 January 2018

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Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis

21 January 2018

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Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes

21 January 2018

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T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes

21 January 2018

1 reference

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection

21 January 2018

1 reference

Cutting edge: immunity and IFN-gamma production during Listeria monocytogenes infection in the absence of T-bet.

21 January 2018

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T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease.

21 January 2018

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T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.

21 January 2018

1 reference

Identification of a novel type 1 diabetes susceptibility gene, T-bet

21 January 2018

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Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

21 January 2018

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Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

21 January 2018

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Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion

21 January 2018

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Asthmatic changes in mice lacking T-bet are mediated by IL-13.

21 January 2018

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T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children

21 January 2018

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T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

21 January 2018

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Transcription factors T-bet and GATA-3 regulate development of airway remodeling.

21 January 2018

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells

21 January 2018

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Transforming growth factor-beta induces development of the T(H)17 lineage

21 January 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

21 January 2018

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

21 January 2018

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

21 January 2018

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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells

21 January 2018

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Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage

21 January 2018

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Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells

21 January 2018

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IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis

21 January 2018

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T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation

21 January 2018

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A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy

21 January 2018

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T-bet inhibits the in vivo differentiation of parasite-specific CD4 Th17 cells in a T cell-intrinsic manner

21 January 2018

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Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17.

21 January 2018

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Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

21 January 2018

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Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system

21 January 2018

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pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity

21 January 2018

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Clinical impact of intravenous methylprednisolone in attacks of multiple sclerosis.

21 January 2018

1 reference

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction

21 January 2018

1 reference

Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment?

21 January 2018

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Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis

21 January 2018

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Regulation of inflammatory responses by IL-17F

21 January 2018

1 reference

IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis.

21 January 2018

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T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

21 January 2018

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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.

21 January 2018

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Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis.

21 January 2018

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Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles

21 January 2018

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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

21 January 2018

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Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

21 January 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

21 January 2018

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Fate mapping of IL-17-producing T cells in inflammatory responses

21 January 2018

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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

21 January 2018

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Foxp3 programs the development and function of CD4 CD25 regulatory T cells

21 January 2018

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Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

21 January 2018

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IL-4 inhibits TGF-beta-induced Foxp3 T cells and, together with TGF-beta, generates IL-9 IL-10 Foxp3(-) effector T cells

21 January 2018

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Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

21 January 2018

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Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

21 January 2018

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 January 2018

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Bcl6 mediates the development of T follicular helper cells

21 January 2018

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Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

21 January 2018

1 reference

Control of Effector CD8 T Cell Function by the Transcription Factor Eomesodermin

21 January 2018

1 reference

Effector and memory CD8 T cell fate coupled by T-bet and eomesodermin

21 January 2018

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Anomalous type 17 response to viral infection by CD8 T cells lacking T-bet and eomesodermin.

21 January 2018

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Inflammation directs memory precursor and short-lived effector CD8( ) T cell fates via the graded expression of T-bet transcription factor

21 January 2018

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The mTOR kinase determines effector versus memory CD8 T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

1 reference

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

21 January 2018

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

21 January 2018

1 reference

CD8 Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice

21 January 2018

1 reference

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17

21 January 2018

1 reference

T-bet regulates T-independent IgG2a class switching

21 January 2018

1 reference

CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells

21 January 2018

1 reference

T-bet plays a key role in NK-mediated control of melanoma metastatic disease

21 January 2018

1 reference

The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells

21 January 2018

1 reference

T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells

21 January 2018

1 reference

Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro.

21 January 2018

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Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes

21 January 2018

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Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

21 January 2018

1 reference

Interferons direct Th2 cell reprogramming to generate a stable GATA-3( )T-bet( ) cell subset with combined Th2 and Th1 cell functions

21 January 2018

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Late developmental plasticity in the T helper 17 lineage

21 January 2018

1 reference

A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease

21 January 2018

1 reference

12 December 2020

Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation

1 reference

12 December 2020

The AP-1 transcription factor Batf controls T(H)17 differentiation

1 reference

12 December 2020

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

1 reference

12 December 2020

Specific immunity to Listeria monocytogenes in the absence of IFN gamma

1 reference

12 December 2020

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1 reference

12 December 2020

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4 T cells

1 reference

12 December 2020

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1 reference

12 December 2020

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1 reference

12 December 2020

High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors.

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12 December 2020

Disparate CD4 lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1 reference

12 December 2020

Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice

1 reference

12 December 2020

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

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12 December 2020

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice

1 reference

12 December 2020

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice

1 reference

12 December 2020

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

12 December 2020

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

1 reference

12 December 2020

Immune response in mice that lack the interferon-gamma receptor

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12 December 2020

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

1 reference

12 December 2020

Double-blind trial of recombinant gamma-interferon versus placebo in the treatment of rheumatoid arthritis

1 reference

12 December 2020

Randomized study of antibodies to IFN-gamma and TNF-alpha in secondary progressive multiple sclerosis

1 reference

12 December 2020

Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.2059

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

Dimensions Publication ID

13 May 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6290474&resulttype=core&format=json

13 May 2020

PubMed publication ID

21685955

1 reference