Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease. (Q37875108)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

review article

1 reference

title

Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Karim Bordji

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

Javier Becerril-Ortega

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

publication date

16 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

Reviews in the Neurosciences

31 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

page(s)

285-294

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice.

31 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

The chemical biology of clinically tolerated NMDA receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Calcium: still center-stage in hypoxic-ischemic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Strategies for disease modification in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Amyloid beta mediates memory formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Pro-survival signalling from the NMDA receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Survival signaling pathways activated by NMDA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Mechanism of action of memantine

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Hypothesis on the regulation of cytosol calcium concentration and the aging brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Calcium, membranes, aging, and Alzheimer's disease. Introduction and overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Pathologically activated therapeutics for neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Excitatory amino acids as a final common pathway for neurologic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Senile plaques in temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Pathways towards and away from Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Calcium ionophore increases amyloid beta peptide production by cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Excitotoxicity and the NMDA receptor--still lethal after eight years

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Cognitive reserve and Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Axonal transport and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Calcium dysregulation, IP3 signaling, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

A beta oligomers - a decade of discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1515/RNS.2011.029

21 January 2018

Identifiers

DOI

10.1515/RNS.2011.029

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21568789 AND SRC:MED&resulttype=core&format=json

31 January 2020

1 reference