Transcriptional and epigenetic networks in haematological malignancy (Q37863271)

24 August 2017

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title

Transcriptional and epigenetic networks in haematological malignancy (English)

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24 August 2017

Ngai Cheung

1

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24 August 2017

Chi Wai Eric So

2

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24 August 2017

language of work or name

English

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publication date

6 April 2011

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full work available at URL

24 August 2017

https://doi.org/10.1016/j.febslet.2011.03.068

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21477587

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016/j.febslet.2011.03.068

29 November 2024

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2011.03.068

29 November 2024

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

29 November 2024

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24 August 2017

volume

585

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24 August 2017

issue

13

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24 August 2017

page(s)

2100-2111

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Chromosomal translocations in human cancer.

24 August 2017

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Translating the Histone Code

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Histone ubiquitination: triggering gene activity

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Crosstalk among Histone Modifications

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New nomenclature for chromatin-modifying enzymes

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Combinatorial patterns of histone acetylations and methylations in the human genome

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

21 January 2018

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Histone arginine methylation and its dynamic regulation

21 January 2018

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JmjC-domain-containing proteins and histone demethylation

21 January 2018

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Dynamic Regulation of Histone Lysine Methylation by Demethylases

21 January 2018

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Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

21 January 2018

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Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark

21 January 2018

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DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

21 January 2018

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

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Facultative heterochromatin: is there a distinctive molecular signature?

21 January 2018

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21 January 2018

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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The critical role of chromosome translocations in human leukemias.

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The impact of translocations and gene fusions on cancer causation

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Transcriptome sequencing to detect gene fusions in cancer

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The molecular signature of oncofusion proteins in acute myeloid leukemia.

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Forced homo-oligomerization of RARalpha leads to transformation of primary hematopoietic cells

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Molecular pathogenesis of acute promyelocytic leukaemia and APL variants

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Translocations of the RARalpha gene in acute promyelocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The Hox genes and their roles in oncogenesis.

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Gene expression profiling in acute myeloid leukaemia (AML).

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

HOXA9 is required for survival in human MLL-rearranged acute leukemias

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Genome regulation by polycomb and trithorax proteins

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Altered Hox expression and segmental identity in Mll-mutant mice

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Definitive hematopoiesis requires the mixed-lineage leukemia gene

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Polycomb silencing mechanisms and the management of genomic programmes

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Role of the polycomb protein EED in the propagation of repressive histone marks

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

A vertebrate Polycomb response element governs segmentation of the posterior hindbrain

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

21 January 2018

The JARID2-PRC2 duality

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

A histone H3 lysine 27 demethylase regulates animal posterior development

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Therapeutic targeting of MLL.

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Dimerization: a versatile switch for oncogenesis

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The molecular biology of mixed lineage leukemia

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

New insights to the MLL recombinome of acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MLL: a histone methyltransferase disrupted in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The PHD fingers of MLL block MLL fusion protein-mediated transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

hDOT1L links histone methylation to leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Protein arginine methylation in mammals: who, what, and why

21 January 2018

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https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Arginine methylation an emerging regulator of protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Regulation of transcription by a protein methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Crosstalk between CARM1 methylation and CBP acetylation on histone H3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Protein arginine-methyltransferase-dependent oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

A proteomic analysis of arginine-methylated protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Paraspeckles: nuclear bodies built on long noncoding RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Histone deimination antagonizes arginine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

JMJD6 is a histone arginine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Long noncoding RNA as modular scaffold of histone modification complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Haploinsufficiency of NSD1 causes Sotos syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MOZ is fused to p300 in an acute monocytic leukemia with t(8;22).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MOZ is essential for maintenance of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Processing the H3K36me3 signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016/J.FEBSLET.2011.03.068

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

21 January 2018

1 reference

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ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation

21 January 2018

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

21 January 2018

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

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The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

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Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 January 2018

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The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

21 January 2018

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Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

21 January 2018

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

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Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

21 January 2018

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Mutations of ASXL1 gene in myeloproliferative neoplasms.

21 January 2018

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Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice

21 January 2018

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Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

21 January 2018

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Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

21 January 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

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TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

21 January 2018

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Mutation in TET2 in myeloid cancers

21 January 2018

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TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia

21 January 2018

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Acquired mutations in TET2 are common in myelodysplastic syndromes

21 January 2018

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Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

21 January 2018

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Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

21 January 2018

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

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Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

21 January 2018

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Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

21 January 2018

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JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

21 January 2018

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Cooperative epigenetic modulation by cancer amplicon genes

21 January 2018

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

21 January 2018

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

21 January 2018

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

21 January 2018

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β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells

21 January 2018

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Transcriptional activation of polycomb-repressed genes by ZRF1

21 January 2018

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The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition

21 January 2018

9

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Expression switching in the stevor and Pfmc-2TM superfamilies in Plasmodium falciparum

29 November 2024

11

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RXR is an essential component of the oncogenic PML/RARA complex in vivo

29 November 2024

38

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Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

29 November 2024

39

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Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing

29 November 2024

52

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Mechanisms of polycomb gene silencing: knowns and unknowns

29 November 2024

55

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Definitive But Not Primitive Hematopoiesis Is Impaired injumonji Mutant Mice

29 November 2024

63

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Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

29 November 2024

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Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML

29 November 2024

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MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

29 November 2024

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Misguided transcriptional elongation causes mixed lineage leukemia

29 November 2024

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Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia

29 November 2024

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Sam68, the KH domain-containing superSTAR.

29 November 2024

118

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All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders

29 November 2024

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Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation

29 November 2024

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ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia

29 November 2024

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Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations

29 November 2024

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

29 November 2024

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Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias

29 November 2024

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

29 November 2024

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29 November 2024

Identifiers

1 reference

24 August 2017

1 reference