Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes. (Q37833892)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21283106 AND SRC:MED&resulttype=core&format=json

21 January 2020

review article

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title

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21283106 AND SRC:MED&resulttype=core&format=json

21 January 2020

1

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21 January 2020

author name string

Kyle L Kolaja

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21283106 AND SRC:MED&resulttype=core&format=json

21 January 2020

publication date

1 February 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21283106 AND SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

21 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21283106 AND SRC:MED&resulttype=core&format=json

21 January 2020

volume

10

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21 January 2020

issue

2

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21 January 2020

page(s)

111-126

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The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture

21 January 2020

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Experimental membranous nephropathy redux

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure

21 January 2018

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Requirement for Ca2 /calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

21 January 2018

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21 January 2018

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21 January 2018

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Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling

21 January 2018

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Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy

21 January 2018

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Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart

21 January 2018

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H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Novel cell lines derived from adult human ventricular cardiomyocytes

21 January 2018

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21 January 2018

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21 January 2018

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Primary Culture of Human Atrial Myocytes is Associated with the Appearance of Structural and Functional Characteristics of Immature Myocardium

21 January 2018

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Hypertension as a predictive factor of Sunitinib activity

21 January 2018

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Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

31 March 2020

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Myocyte hypertrophy in neonatal rat heart cultures and its regulation by serum and by catecholamines

31 March 2020

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Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Cross-striations, ultrastructure, and chronotropic response to isoproterenol

31 March 2020

1 reference

The use of in vivo zebrafish assays in drug toxicity screening

31 March 2020

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Pretreatment with ICRF-187 provides long-lasting protection against chronic daunorubicin cardiotoxicity in rabbits

31 March 2020

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Randomized clinical trial comparing mitoxantrone with doxorubicin in previously treated patients with metastatic breast cancer

31 March 2020

1 reference

Effect of Exercise on Cardiac Output, Left Coronary Flow and Myocardial Metabolism in the Unanesthetized Dog

31 March 2020

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Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practice

31 March 2020

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Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate

31 March 2020

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Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy

31 March 2020

1 reference

Noonan syndrome and related disorders: dysregulated RAS-mitogen activated protein kinase signal transduction

31 March 2020

1 reference

Akt1 is required for physiological cardiac growth

31 March 2020

1 reference

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

31 March 2020

1 reference

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study

31 March 2020

1 reference

Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice

31 March 2020

1 reference

Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes

31 March 2020

1 reference

Rapid ventricular repolarization in rodents: electrocardiographic manifestations, molecular mechanisms, and clinical insights

31 March 2020

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Longevity of adult ventricular rat heart muscle cells in serum-free primary culture

31 March 2020

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Long-term primary cultures of human adult atrial cardiac myocytes: cell viability, structural properties and BNP secretion in vitro

31 March 2020

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Human pediatric and adult ventricular cardiomyocytes in culture: assessment of phenotypic changes with passaging

31 March 2020

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Cardiac physiology at the cellular level: use of cultured HL-1 cardiomyocytes for studies of cardiac muscle cell structure and function

31 March 2020

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12 December 2020

Retro-orbital injection in adult zebrafish

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12 December 2020

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

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12 December 2020

Troponin I as a marker of doxorubicin induced cardiotoxicity.

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12 December 2020

Prolonged myocardial nucleotide depletion after brief ischemia in the open-chest dog

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12 December 2020

Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function

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12 December 2020

Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

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12 December 2020

Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

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12 December 2020

Echocardiography in the assessment of heart failure

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12 December 2020

Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure

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12 December 2020

Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity.

1 reference

12 December 2020

Reduction of chronic daunorubicin cardiotoxicity by ICRF-187 in rabbits

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12 December 2020

Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers

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12 December 2020

Identifiers

DOI

10.1038/NRD3252

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21283106 AND SRC:MED&resulttype=core&format=json

21 January 2020

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