DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis. (Q37828633)

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20 January 2020

review article

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title

DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis (English)

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20 January 2020

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2

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20 January 2020

author name string

Sugako Oka

series ordinal

1

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20 January 2020

publication date

17 February 2011

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20 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21235684 AND SRC:MED&resulttype=core&format=json

20 January 2020

volume

102

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20 January 2020

issue

4

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20 January 2020

page(s)

677-682

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Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.

20 January 2020

cites work

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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

21 January 2018

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Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase

21 January 2018

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Base excision repair of 8-hydroxyguanine protects DNA from endogenous oxidative stress

21 January 2018

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Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

21 January 2018

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Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

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Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors

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Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors

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Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH

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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.

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Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.

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Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

21 January 2018

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Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase

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Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts

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A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA

21 January 2018

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Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

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Germline susceptibility to colorectal cancer due to base-excision repair gene defects

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Base-excision repair of oxidative DNA damage

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Clinical Implications of the Colorectal Cancer Risk Associated With MUTYH Mutation

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Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea

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Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis.

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Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH

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Frequency of the Common MYH Mutations (G382D and Y165C) in MMR Mutation Positive and Negative HNPCC Patients

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Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer

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An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

21 January 2018

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Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

21 January 2018

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Replication-associated repair of adenine:8-oxoguanine mispairs by MYH.

21 January 2018

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An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda

21 January 2018

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Futile short-patch DNA base excision repair of adenine:8-oxoguanine mispair

21 January 2018

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21 January 2018

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Structure of Human DNA Polymerase κ Inserting dATP Opposite an 8-OxoG DNA Lesion

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Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

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21 January 2018

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