APP transgenic mice: their use and limitations (Q37820330)

23 August 2017

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title

APP transgenic mice: their use and limitations (English)

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23 August 2017

Claudia Balducci

1

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23 August 2017

Gianluigi Forloni

series ordinal

2

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23 August 2017

publication date

9 December 2010

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23 August 2017

published in

NeuroMolecular Medicine

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23 August 2017

volume

13

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23 August 2017

issue

2

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23 August 2017

page(s)

117-137

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LTP maintenance and its protein synthesis-dependence

23 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.

21 January 2018

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Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images.

21 January 2018

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Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice

21 January 2018

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Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

21 January 2018

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21 January 2018

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Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells

21 January 2018

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21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease.

21 January 2018

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Correlation between cognitive deficits and Abeta deposits in transgenic APP PS1 mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

21 January 2018

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Various dendritic abnormalities are associated with fibrillar amyloid deposits in Alzheimer's disease

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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APP transgenic mouse models and their use in drug discovery to evaluate amyloid- lowering therapeutics

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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BCL-xL regulates synaptic plasticity

21 January 2018

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APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

21 January 2018

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21 January 2018

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Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.

21 January 2018

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Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease

21 January 2018

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Hyperaccumulation of FAD-linked presenilin 1 variants in vivo

21 January 2018

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Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

21 January 2018

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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography

21 January 2018

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Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.

21 January 2018

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Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

21 January 2018

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Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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21 January 2018

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Mitochondria in neuroplasticity and neurological disorders

21 January 2018

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A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

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Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

21 January 2018

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

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Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes

21 January 2018

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

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Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

21 January 2018

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

21 January 2018

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21 January 2018

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Developments of a water-maze procedure for studying spatial learning in the rat

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

A dynamic relationship between intracellular and extracellular pools of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

The radial arm maze as a tool in behavioral pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Cerebral hemorrhage after passive anti-Abeta immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Recognition memory and the medial temporal lobe: a new perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

The molecular basis of the prevention of Alzheimer's disease through healthy nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Drug discovery in dementia: the role of rodent models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

A beta oligomers - a decade of discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Independent effects of intra- and extracellular Abeta on learning-related gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Inflammation in neurodegenerative disease--a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Neuron loss in APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S12017-010-8141-7

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

21 January 2018

1 reference

12 December 2020

Amyloid plaque imaging in vivo: current achievement and future prospects.

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1 reference

12 December 2020

Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures

1 reference

12 December 2020

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome

1 reference

12 December 2020

The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.

1 reference

12 December 2020

Glial conditioned medium alters the expression of amyloid precursor protein in SH-SY5Y neuroblastoma cells

1 reference

12 December 2020

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

1 reference

12 December 2020

Biological markers for early detection and pharmacological treatment of Alzheimer's disease

1 reference

12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

1 reference

12 December 2020

Amidation of β‐Amyloid Peptide Strongly Reduced the Amyloidogenic Activity Without Alteration of the Neurotoxicity

1 reference

12 December 2020

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

New biochemical insights to unravel the pathogenesis of Alzheimer's lesions.

1 reference

12 December 2020

Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease

1 reference

12 December 2020

TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs

1 reference

12 December 2020

Behavioral models of memory and amnesia

1 reference

12 December 2020

Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease

1 reference

12 December 2020

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

1 reference

12 December 2020

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1 reference

12 December 2020

Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

1 reference

12 December 2020

Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

1 reference

12 December 2020

Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

MR microimaging of amyloid plaques in Alzheimer's disease transgenic mice

1 reference

12 December 2020

Cerebrospinal fluid biomarkers for Alzheimer's disease

1 reference

12 December 2020

Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's disease

1 reference

12 December 2020

Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain

1 reference

12 December 2020

The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease

1 reference

12 December 2020

Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease

1 reference

12 December 2020

Cognitive Deficits Associated with Alteration of Synaptic Metaplasticity Precede Plaque Deposition in AβPP23 Transgenic Mice

1 reference

12 December 2020

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.

1 reference

12 December 2020

Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis.

1 reference

12 December 2020

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

1 reference

12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

12 December 2020

Mitochondrial abnormalities in Alzheimer's disease.

1 reference

12 December 2020

Effect of a carboxy-terminal fragment of the alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells

1 reference

12 December 2020

Treatment of Alzheimer's disease: the role of symptomatic agents in an era of disease-modifying therapies

1 reference

12 December 2020

10.1007/S12017-010-8141-7

Identifiers

DOI

1 reference

23 August 2017

1 reference