A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17) (Q37811303)

23 August 2017

title

A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17) (English)

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

31 August 2024

author name string

Muhammad Akhtar

1

1 reference

23 August 2017

Peter Lee-Robichaud

3

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23 August 2017

J. Neville Wright

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21094255

31 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21094255

31 August 2024

publication date

19 November 2010

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full work available at URL

23 August 2017

https://api.elsevier.com/content/article/PII:S0960076010003626?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

https://api.elsevier.com/content/article/PII:S0960076010003626?httpAccept=text/plain

31 August 2024

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https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The Journal of Steroid Biochemistry and Molecular Biology

31 August 2024

published in

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23 August 2017

volume

125

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23 August 2017

issue

1-2

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23 August 2017

page(s)

2-12

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The intermediary role of a 19-oxoandrogen in the biosynthesis of oestrogen

23 August 2017

cites work

2

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The intermediate steps in the biosynthesis of estrogens from androgens

31 August 2024

3

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Purification to homogeneity of aromatase from human placenta

31 August 2024

5

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

31 August 2024

7

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Purification and reconstitution properties of human placental aromatase. A cytochrome P-450-type monooxygenase

31 August 2024

8

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The stereospecific removal of a C-19 hydrogen atom in oestrogen biosynthesis

31 August 2024

9

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

31 August 2024

11

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Reassignment of the absolute configuration of 19-substituted 19-hydroxysteroids and stereomechanism of estrogen biosynthesis

31 August 2024

13

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Mechanistic studies on C-19 demethylation in oestrogen biosynthesis

31 August 2024

15

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Studies on the mechanism of estrogen biosynthesis. 3. The stereochemistry of aromatization of C19 and C18 steroids

31 August 2024

18

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens

31 August 2024

19

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase

31 August 2024

21

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The final catalytic step of cytochrome p450 aromatase: a density functional theory study.

31 August 2024

22

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.

31 August 2024

23

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

A unified mechanistic view of oxidative reactions catalysed by P-450 and related Fe-containing enzymes

31 August 2024

24

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Cytochrome P450cam and its complexes, Mo¨ssbauer parameters of the heme iron

31 August 2024

27

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The Magnetic Properties and Structure of Hemoglobin, Oxyhemoglobin and Carbonmonoxyhemoglobin

31 August 2024

28

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Nature of the Iron–Oxygen Bond in Oxyhæmoglobin

31 August 2024

29

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Nature of the Iron–Oxygen Bond in Oxyhæmoglobin

31 August 2024

30

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450

31 August 2024

31

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

X-ray absorption studies of intermediates in peroxidase activity

31 August 2024

32

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Probing Structure-Function Relations in Heme-Containing Oxygenases and Peroxidases

31 August 2024

33

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes

31 August 2024

35

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation

31 August 2024

36

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The critical iron-oxygen intermediate in human aromatase

31 August 2024

37

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Studies on estrogen biosynthesis using radioactive and stable isotopes

31 August 2024

38

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Aromatase reaction of 3-deoxyandrogens: steric mode of the C-19 oxygenation and cleavage of the C10-C19 bond by human placental aromatase

31 August 2024

39

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Kinetic properties of aromatase mutants Pro308Phe, Asp309Asn, and Asp309Ala and their interactions with aromatase inhibitors

31 August 2024

40

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation

31 August 2024

41

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Crystallographic study on the dioxygen complex of wild-type and mutant cytochrome P450cam. Implications for the dioxygen activation mechanism

31 August 2024

42

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF.

31 August 2024

43

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

A three-dimensional model of aromatase cytochrome P450.

31 August 2024

44

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps

31 August 2024

45

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Androgen Steroids as an Aid to the Detection of Oestrus in Pig Artificial Insemination

31 August 2024

47

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora--a mechanism for axillary odour production in man?

31 August 2024

48

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Secretion by the human testis of epitestosterone, with its sulfoconjugate and precursor androgen 5-androstene-3 beta,17 alpha-diol

31 August 2024

49

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Mechanism of the acyl-carbon cleavage and related reactions catalyzed by multifunctional P-450s: studies on cytochrome P-450(17)alpha

31 August 2024

52

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-45017.alpha.; 17.alpha.-hydroxylase-17,20-lyase)

31 August 2024

55

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The role of cytochrome b5 in the biosynthesis of androgens by human P450c17.

31 August 2024

56

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Modulation of the activity of human 17 alpha-hydroxylase-17,20-lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications

31 August 2024

57

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The mechanism of the acyl-carbon bond cleavage reaction catalyzed by recombinant sterol 14 alpha-demethylase of Candida albicans (other names are: lanosterol 14 alpha-demethylase, P-45014DM, and CYP51)

31 August 2024

59

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.

31 August 2024

60

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Immunohistochemistry and in situ hybridization of P-45017 alpha (17 alpha-hydroxylase/17,20-lyase)

31 August 2024

61

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Colocalization of P450c17 and cytochrome b5 in androgen-synthesizing tissues of the human.

31 August 2024

62

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies

31 August 2024

64

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Testicular cytochrome P-450 and iron-sulfur protein as related to steroid metabolism.

31 August 2024

65

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

High expression of cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome associated with high secretion of adrenal androgens

31 August 2024

66

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

In-vitro evidence for the regulation of 17,20-lyase activity by cytochrome b5 in adrenocortical adenomas from patients with Cushing's syndrome

31 August 2024

67

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Mechanism of abnormal production of adrenal androgens in patients with adrenocortical adenomas and carcinomas

31 August 2024

68

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome

31 August 2024

69

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

31 August 2024

70

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The genetic and functional basis of isolated 17,20-lyase deficiency

31 August 2024

71

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Control of androgen biosynthesis in the human through the interaction of Arg347 and Arg358 of CYP17 with cytochrome b5

31 August 2024

72

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities

31 August 2024

74

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17.

31 August 2024

75

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Interaction of purified microsomal cytochrome P-450 with cytochrome b5

31 August 2024

76

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The roles of cytochrome b5 in a reconstituted N-demethylase system containing cytochrome P-450

31 August 2024

77

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Roles of residues 129 and 209 in the alteration by cytochrome b5 of hydroxylase activities in mouse 2A P450S

31 August 2024

79

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.

31 August 2024

82

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions

31 August 2024

83

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

The Journal of Clinical Endocrinology and Metabolism

31 August 2024

84

84

3382

Mapes

1999

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17

31 August 2024

85

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

'Slow-binding' sixth-ligand inhibitors of cytochrome P-450 aromatase. Studies with 19-thiomethyl- and 19-azido-androstenedione

31 August 2024

88

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Mechanism and inhibition of cytochrome P-450 aromatase

31 August 2024

90

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Novel Steroidal Inhibitors of Human Cytochrome P45017.alpha.-Hydroxylase-C17,20-lyase): Potential Agents for the Treatment of Prostatic Cancer

31 August 2024

91

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

Peroxo-iron mediated deformylation in sterol 14alpha-demethylase catalysis

31 August 2024

92

1 reference

https://api.crossref.org/works/10.1016/J.JSBMB.2010.11.003

31 August 2024

Identifiers

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23 August 2017

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