Retroviral Vectors for Gene Therapy (Q37809064)

23 August 2017

title

Retroviral vectors for gene therapy (English)

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23 August 2017

Retroviral Vectors for Gene Therapy (English)

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25 August 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21073311

25 August 2024

2

Christof von Kalle

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author name string

Patrick Maier

1

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23 August 2017

Stephanie Laufs

3

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23 August 2017

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21073311

25 August 2024

publication date

1 October 2010

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full work available at URL

23 August 2017

number of pages

17

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based on heuristic

inferred from page(s)

http://www.futuremedicine.com/doi/abs/10.2217/fmb.10.100

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21073311

https://www.tandfonline.com/doi/pdf/10.2217/fmb.10.100

25 August 2024

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25 August 2024

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23 August 2017

volume

5

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23 August 2017

issue

10

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23 August 2017

page(s)

1507-1523

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Gene delivery by lentivirus vectors

23 August 2017

cites work

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The basic science of gene therapy

21 January 2018

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Gene therapy: the first two decades and the current state-of-the-art

21 January 2018

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Non-viral gene delivery systems

21 January 2018

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Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo

21 January 2018

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Intracellular barriers to non-viral gene transfer.

21 January 2018

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Gene therapy with viral vectors

21 January 2018

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Genetics of retroviral integration

21 January 2018

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Lentiviruses as gene transfer agents for delivery to non-dividing cells

21 January 2018

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A nucleoprotein complex mediates the integration of retroviral DNA.

21 January 2018

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Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein

21 January 2018

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Isolation of high-affinity RNA ligands to HIV-1 integrase from a random pool

21 January 2018

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Foamy virus vectors for gene transfer

21 January 2018

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Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges

21 January 2018

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No false start for novel pseudotyped vectors

21 January 2018

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Oncoretrovirus and lentivirus vectors pseudotyped with lymphocytic choriomeningitis virus glycoprotein: generation, concentration, and broad host range

21 January 2018

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Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

21 January 2018

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Efficient functional pseudotyping of oncoretroviral and lentiviral vectors by Venezuelan equine encephalitis virus envelope proteins.

21 January 2018

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Murine retroviral pseudotype virus containing hepatitis B virus large and small surface antigens confers specific tropism for primary human hepatocytes: a potential liver-specific targeting system

21 January 2018

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Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection

21 January 2018

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Efficient gene transfer into the CNS by lentiviral vectors purified by anion exchange chromatography

21 January 2018

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Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

21 January 2018

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Viral entry into the nucleus

21 January 2018

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Human gene therapy vectors derived from feline lentiviruses

21 January 2018

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Defective RNA packaging is responsible for low transduction efficiency of CAEV-based vectors

21 January 2018

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Construction and molecular analysis of gene transfer systems derived from bovine immunodeficiency virus

21 January 2018

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Gene transfer systems derived from Visna virus: analysis of virus production and infectivity

21 January 2018

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Systematic determination of the packaging limit of lentiviral vectors

21 January 2018

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Continuous high-titer HIV-1 vector production.

21 January 2018

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Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors

21 January 2018

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A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors

21 January 2018

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Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection

21 January 2018

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Inducible packaging cells for large-scale production of lentiviral vectors in serum-free suspension culture

21 January 2018

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Production of lentiviral vectors by large-scale transient transfection of suspension cultures and affinity chromatography purification

21 January 2018

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Downstream processing of oncoretroviral and lentiviral gene therapy vectors

21 January 2018

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Regulation of human immunodeficiency virus replication

21 January 2018

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

21 January 2018

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In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins

21 January 2018

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Large-scale production of pseudotyped lentiviral vectors using baculovirus GP64.

21 January 2018

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Optimized large-scale production of high titer lentivirus vector pseudotypes

21 January 2018

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Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha

21 January 2018

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Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells

21 January 2018

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Lentiviral vectors pseudotyped with envelope glycoproteins derived from gibbon ape leukemia virus and murine leukemia virus 10A1.

21 January 2018

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Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34 cells derived from human and nonhuman primates.

21 January 2018

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Targeted cell entry of lentiviral vectors

21 January 2018

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Gene transfer to respiratory epithelia with lentivirus pseudotyped with Jaagsiekte sheep retrovirus envelope glycoprotein

21 January 2018

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Lentiviruses in gene therapy clinical research

21 January 2018

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High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter

21 January 2018

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

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Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state

21 January 2018

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Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus

21 January 2018

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Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

21 January 2018

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Use of the human elongation factor 1 alpha promoter as a versatile and efficient expression system

21 January 2018

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Factors influencing the titer and infectivity of lentiviral vectors.

21 January 2018

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Optimization of transgene expression at the posttranscriptional level in neural cells: implications for gene therapy

21 January 2018

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Stable transduction of quiescent CD34( )CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors

21 January 2018

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Transduction of human CD34 cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors

21 January 2018

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Lentiviral gene transfer into peripheral blood-derived CD34 NOD/SCID-repopulating cells

21 January 2018

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Use of retroviral vectors for gene transfer and expression

21 January 2018

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Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K).

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Factors affecting retroviral vector function and structural integrity

21 January 2018

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Quantitative analysis of gene suppression in integrated retrovirus vectors

21 January 2018

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Construction and applications of a highly transmissible murine retrovirus shuttle vector

21 January 2018

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Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

21 January 2018

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Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis

21 January 2018

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Reconstitution of a metabolic pathway with triple-cistronic IRES-containing retroviral vectors for correction of tetrahydrobiopterin deficiency

21 January 2018

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Retroviral bicistronic vectors

21 January 2018

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Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation

21 January 2018

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Improved co-expression of multiple genes in vectors containing internal ribosome entry sites (IRESes) from human genes.

21 January 2018

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IRES-dependent second gene expression is significantly lower than cap-dependent first gene expression in a bicistronic vector

21 January 2018

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Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins.

21 January 2018

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Development of 2A peptide-based strategies in the design of multicistronic vectors

21 January 2018

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Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence

21 January 2018

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The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences

21 January 2018

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Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide

21 January 2018

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Deletion mapping of the encephalomyocarditis virus primary cleavage site

21 January 2018

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Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

21 January 2018

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector

21 January 2018

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Use of the 2A sequence from foot-and-mouth disease virus in the generation of retroviral vectors for gene therapy

21 January 2018

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Reprogramming of murine and human somatic cells using a single polycistronic vector

21 January 2018

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Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells

21 January 2018

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Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame

21 January 2018

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Clinical application of lentiviral vectors - concepts and practice

21 January 2018

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Gene therapy for human genetic disease?

21 January 2018

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Gene therapy in peripheral blood lymphocytes and bone marrow for ADA- immunodeficient patients

21 January 2018

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Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

21 January 2018

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Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

21 January 2018

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

21 January 2018

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Recent advances in gene therapy for severe congenital immunodeficiency diseases

21 January 2018

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Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

21 January 2018

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Progress and prospects: gene therapy for inherited immunodeficiencies

21 January 2018

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

21 January 2018

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Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

21 January 2018

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Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

21 January 2018

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Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line

21 January 2018

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Retroviral vector integration occurs in preferred genomic targets of human bone marrow-repopulating cells

21 January 2018

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Comprehensive genomic access to vector integration in clinical gene therapy

21 January 2018

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High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

21 January 2018

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Polyclonal long-term repopulating stem cell clones in a primate model

21 January 2018

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QuickMap: a public tool for large-scale gene therapy vector insertion site mapping and analysis

21 January 2018

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Lentiviral vector integration sites in human NOD/SCID repopulating cells

21 January 2018

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Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

21 January 2018

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Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

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Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

21 January 2018

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HIV-1 integration in the human genome favors active genes and local hotspots

21 January 2018

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Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

21 January 2018

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The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

21 January 2018

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Simian immunodeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft

21 January 2018

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Ten years of gene therapy for primary immune deficiencies.

21 January 2018

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Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

21 January 2018

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On the road to gene therapy for beta-thalassemia and sickle cell anemia

21 January 2018

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Gene therapy fulfilling its promise

21 January 2018

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Silencing and variegation of gammaretrovirus and lentivirus vectors

21 January 2018

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Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

21 January 2018

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Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

21 January 2018

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Progress toward vector design for hematopoietic stem cell gene therapy

21 January 2018

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

21 January 2018

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Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells

21 January 2018

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Physiological promoters reduce the genotoxic risk of integrating gene vectors

21 January 2018

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Characterization of the chicken beta-globin insulator

21 January 2018

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The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

21 January 2018

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Cohesins functionally associate with CTCF on mammalian chromosome arms

21 January 2018

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Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects

21 January 2018

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High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors

21 January 2018

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Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

21 January 2018

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Integration-deficient lentiviral vectors: a slow coming of age.

21 January 2018

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Non-integrating lentiviral vectors.

21 January 2018

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Oncogenic potentials of the human polyomavirus regulatory proteins

21 January 2018

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The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold

21 January 2018

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Transient gene expression by nonintegrating lentiviral vectors

21 January 2018

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Targeted genome modifications using integrase-deficient lentiviral vectors

21 January 2018

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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

21 January 2018

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study.

21 January 2018

1 reference

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

21 January 2018

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The mechanism of naked DNA uptake and expression

21 January 2018

8

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Retrovirus-induced cell fusion is enhanced by protease treatment

25 August 2024

12

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Design of retroviral vectors and helper cells for gene therapy.

25 August 2024

14

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Construction and properties of retrovirus packaging cells based on gibbon ape leukemia virus

25 August 2024

22

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Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

25 August 2024

29

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Nuclear import of human immunodeficiency virus type-1 preintegration complexes.

25 August 2024

32

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Efficient pseudotyping of murine leukemia virus particles with chimeric human foamy virus envelope proteins

25 August 2024

55

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Specific integration of REV proviruses in avian bursal lymphomas

25 August 2024

64

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A third-generation lentivirus vector with a conditional packaging system

25 August 2024

70

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Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

25 August 2024

73

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Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes.

25 August 2024

83

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The cleavage activities of aphthovirus and cardiovirus 2A proteins

25 August 2024

96

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Mutagenesis by retroviral transgene insertion: risk assessment and potential alternatives.

25 August 2024

123

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No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells

25 August 2024

124

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Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome.

25 August 2024

138

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Effect of scaffold attachment region on transgene expression in retrovirus vector-transduced primary T cells and macrophages

25 August 2024

161

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25 August 2024

Identifiers

DOI

10.2217/FMB.10.100

1 reference

23 August 2017

1 reference