Diabetes as a disease of endoplasmic reticulum stress (Q37797970)

23 August 2017

title

Diabetes as a disease of endoplasmic reticulum stress (English)

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23 August 2017

main subject

endoplasmic reticulum

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Stefan J Marciniak

5

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author name string

Sally E Thomas

1

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23 August 2017

Lucy E Dalton

2

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23 August 2017

Marie-Louise Daly

3

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23 August 2017

Elke Malzer

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23 August 2017

publication date

3 October 2010

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Diabetes - Metabolism: Research and Reviews

23 August 2017

published in

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23 August 2017

volume

26

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23 August 2017

issue

8

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23 August 2017

page(s)

611-621

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The first and fourth upstream open reading frames in GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to change in length and sequence

23 August 2017

cites work

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Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

21 January 2018

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

21 January 2018

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Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins

21 January 2018

1 reference

Evidence for the interaction between Translin and GADD34 in mammalian cells

21 January 2018

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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

21 January 2018

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

21 January 2018

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Endoplasmic reticulum stress signaling in disease

21 January 2018

1 reference

7 January 2021

Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum

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7 January 2021

The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum

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7 January 2021

ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

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7 January 2021

Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response

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7 January 2021

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

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7 January 2021

Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta

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7 January 2021

Manipulation of oxidative protein folding and PDI redox state in mammalian cells

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7 January 2021

Coordinated nonvectorial folding in a newly synthesized multidomain protein

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7 January 2021

Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death

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7 January 2021

The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation).

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7 January 2021

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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7 January 2021

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

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7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

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7 January 2021

Transcriptional and translational control in the Mammalian unfolded protein response

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7 January 2021

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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7 January 2021

Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia

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7 January 2021

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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7 January 2021

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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7 January 2021

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

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7 January 2021

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis

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7 January 2021

Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha

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7 January 2021

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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7 January 2021

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

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7 January 2021

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

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7 January 2021

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

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7 January 2021

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

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7 January 2021

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

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7 January 2021

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

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7 January 2021

Stress-induced gene expression requires programmed recovery from translational repression

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7 January 2021

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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7 January 2021

Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation

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7 January 2021

Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.

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7 January 2021

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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7 January 2021

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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7 January 2021

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response.

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7 January 2021

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

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7 January 2021

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

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7 January 2021

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

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7 January 2021

The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2 /Akita pancreatic beta cells.

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7 January 2021

High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin

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7 January 2021

Proinsulin maturation, misfolding, and proteotoxicity

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7 January 2021

Insulin gene mutations as a cause of permanent neonatal diabetes

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7 January 2021

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

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7 January 2021

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

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7 January 2021

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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7 January 2021

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

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7 January 2021

Interaction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagent

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7 January 2021

Interaction between GADD34 and kinesin superfamily, KIF3A

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7 January 2021

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis

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7 January 2021

The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity

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7 January 2021

Human BAG-1 Proteins Bind to the Cellular Stress Response Protein GADD34 and Interfere with GADD34 Functions

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7 January 2021

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

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7 January 2021

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

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7 January 2021

The biology of incretin hormones

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7 January 2021

Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis

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7 January 2021

Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo

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7 January 2021

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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7 January 2021

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress

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7 January 2021

Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies

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7 January 2021

Regulation of cap-dependent translation by eIF4E inhibitory proteins

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7 January 2021

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

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7 January 2021

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

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7 January 2021

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

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7 January 2021

Antioxidant enzyme activity and mRNA expression in the islets of Langerhans from the BB/S rat model of type 1 diabetes and an insulin-producing cell line

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7 January 2021

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

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7 January 2021

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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7 January 2021

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

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7 January 2021

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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7 January 2021

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

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7 January 2021

Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast

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7 January 2021

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

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7 January 2021

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

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7 January 2021

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

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7 January 2021

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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7 January 2021

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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7 January 2021

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

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7 January 2021

A time-dependent phase shift in the mammalian unfolded protein response

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7 January 2021

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

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7 January 2021

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands

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7 January 2021

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

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7 January 2021

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

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7 January 2021

The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response

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7 January 2021

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

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7 January 2021

Plasma cell differentiation requires the transcription factor XBP-1

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7 January 2021

Bypassing a Kinase Activity with an ATP-Competitive Drug

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7 January 2021

A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress

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7 January 2021

IRE1 signaling affects cell fate during the unfolded protein response

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7 January 2021

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

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7 January 2021

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

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7 January 2021

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

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7 January 2021

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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7 January 2021

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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7 January 2021

ASK1 is essential for JNK/SAPK activation by TRAF2

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7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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7 January 2021

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

1 reference

7 January 2021

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

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7 January 2021

Human caspase 12 has acquired deleterious mutations

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7 January 2021

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

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7 January 2021

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

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7 January 2021

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

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7 January 2021

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

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7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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7 January 2021

The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

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7 January 2021

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

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7 January 2021

Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

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7 January 2021

Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha

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7 January 2021

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2 ATPase 2b and deplete endoplasmic reticulum Ca2 , leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

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7 January 2021

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

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7 January 2021

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

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7 January 2021

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

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7 January 2021

Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells

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7 January 2021

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

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7 January 2021

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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7 January 2021

Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes

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7 January 2021

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

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7 January 2021

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

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7 January 2021

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

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7 January 2021

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

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7 January 2021

Effects of palmitate on ER and cytosolic Ca2 homeostasis in beta-cells

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7 January 2021

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

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7 January 2021

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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7 January 2021

Molecular design and biological activities of protein-tyrosine phosphatase inhibitors

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7 January 2021

Cellular effects of small molecule PTP1B inhibitors on insulin signaling

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7 January 2021

Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress

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7 January 2021

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance

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7 January 2021

Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation

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7 January 2021

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

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7 January 2021

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

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7 January 2021

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

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7 January 2021

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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7 January 2021

Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis

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7 January 2021

Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency

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7 January 2021

Luman is capable of binding and activating transcription from the unfolded protein response element

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7 January 2021

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes

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7 January 2021

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

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7 January 2021

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

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7 January 2021

A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis

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7 January 2021

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

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7 January 2021

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis

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7 January 2021

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

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7 January 2021

The pancreatic ductal epithelium serves as a potential pool of progenitor cells

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7 January 2021

beta-cell neogenesis during prolonged hyperglycemia in rats

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7 January 2021

Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells

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7 January 2021

Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes

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7 January 2021

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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7 January 2021

Recovery from diabetes in mice by beta cell regeneration

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7 January 2021

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

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7 January 2021

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

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7 January 2021

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice

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7 January 2021

Hypoxia-induced energy stress regulates mRNA translation and cell growth

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7 January 2021

Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

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7 January 2021

PERK mediates cell-cycle exit during the mammalian unfolded protein response

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7 January 2021

PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation

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7 January 2021

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest

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7 January 2021

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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7 January 2021

Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta

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7 January 2021

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

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7 January 2021

The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

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7 January 2021

Regulation of HDM2 activity by the ribosomal protein L11

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7 January 2021

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

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7 January 2021

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

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7 January 2021

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

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7 January 2021

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

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7 January 2021

Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress

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7 January 2021

Identifiers

DOI

10.1002/DMRR.1132

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23 August 2017

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