The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions (Q37784732)

23 August 2017

title

The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions (English)

1 reference

23 August 2017

The MAP Kinase Signaling Cascades: A System of Hundreds of Components Regulates a Diverse Array of Physiological Functions (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

5 July 2024

1 reference

1 reference

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MAP kinase kinase kinase kinase activity

Gene Ontology ID

GO:0000165

1 reference

1 reference

Gene Ontology ID

GO:0070375

ERK1 and ERK2 cascade

1 reference

MAP kinase signaling system

Gene Ontology ID

GO:0070371

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20811974

5 July 2024

author name string

Yonat Keshet

1

1 reference

23 August 2017

Rony Seger

2

1 reference

23 August 2017

language of work or name

English

0 references

publication date

1 January 2010

1 reference

full work available at URL

23 August 2017

http://link.springer.com/content/pdf/10.1007/978-1-60761-795-2_1

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Methods in Molecular Biology

5 July 2024

published in

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23 August 2017

volume

661

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23 August 2017

page(s)

3-38

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ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK

23 August 2017

cites work

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

5 July 2024

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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

5 July 2024

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

5 July 2024

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

5 July 2024

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Components of a new human protein kinase signal transduction pathway

5 July 2024

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Primary Structure of BMK1: A New Mammalian MAP Kinase

5 July 2024

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Atypical mitogen-activated protein kinases: structure, regulation and functions

5 July 2024

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Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

5 July 2024

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c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

5 July 2024

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MAP kinase signalling pathways in cancer

5 July 2024

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Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

5 July 2024

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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

5 July 2024

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Regulatory mechanisms and function of ERK MAP kinases

5 July 2024

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The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

5 July 2024

25

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

5 July 2024

26

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Signal transduction and oncogenesis by ErbB/HER receptors

5 July 2024

27

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor

5 July 2024

28

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Ion channels as physiological effectors for growth factor receptor and Ras/ERK signaling pathways.

5 July 2024

29

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Raf-1 activates MAP kinase-kinase

5 July 2024

30

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Meiotic maturation in Xenopus requires polyadenylation of multiple mRNAs

5 July 2024

31

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The RAF proteins take centre stage

5 July 2024

32

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Protein kinase C alpha activates RAF-1 by direct phosphorylation

5 July 2024

33

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

5 July 2024

34

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

5 July 2024

36

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

5 July 2024

37

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade

5 July 2024

43

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro

5 July 2024

44

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function

5 July 2024

46

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Heterogeneous expression of four MAP kinase isoforms in human tissues

5 July 2024

47

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

5 July 2024

48

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

5 July 2024

49

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

5 July 2024

50

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

5 July 2024

51

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

5 July 2024

52

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

5 July 2024

53

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells

5 July 2024

54

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

5 July 2024

55

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

p38 MAP-kinases pathway regulation, function and role in human diseases

5 July 2024

56

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The pathways to tumor suppression via route p38.

5 July 2024

57

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The p38 MAPK stress pathway as a tumor suppressor or more?

5 July 2024

58

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Non-classical p38 map kinase functions: cell cycle checkpoints and survival

5 July 2024

59

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Targeting protein kinases for the development of anti-inflammatory drugs

5 July 2024

60

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

SRC family kinases in cell volume regulation

5 July 2024

61

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Rho GTPases and the control of cell behaviour

5 July 2024

62

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The Ste20 group kinases as regulators of MAP kinase cascades

5 July 2024

63

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Wiring diagrams of MAPK regulation by MEKK1, 2, and 3.

5 July 2024

64

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

5 July 2024

65

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

5 July 2024

66

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MEK7-dependent activation of p38 MAP kinase in keratinocytes

5 July 2024

68

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

5 July 2024

69

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

5 July 2024

70

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

5 July 2024

71

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases

5 July 2024

72

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

5 July 2024

73

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase

5 July 2024

75

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

PRAK, a novel protein kinase regulated by the p38 MAP kinase

5 July 2024

76

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase

5 July 2024

77

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter

5 July 2024

78

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

5 July 2024

79

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The c-jun kinase/stress-activated pathway: regulation, function and role in human disease

5 July 2024

80

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Physiological roles of MKK4 and MKK7: insights from animal models

5 July 2024

81

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The JNK signal transduction pathway

5 July 2024

82

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Inhibitors of c-Jun N-terminal kinases: JuNK no more?

5 July 2024

83

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

JNK signaling in apoptosis

5 July 2024

84

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Modulation of life and death by the TNF receptor superfamily

5 July 2024

85

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

5 July 2024

86

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Ste20-type kinases: evolutionarily conserved regulators of ion transport and cell volume.

5 July 2024

87

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MAP3Ks as central regulators of cell fate during development

5 July 2024

88

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

5 July 2024

89

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

5 July 2024

90

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

5 July 2024

91

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

5 July 2024

92

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.

5 July 2024

93

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases

5 July 2024

94

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Selective interaction of JNK protein kinase isoforms with transcription factors

5 July 2024

95

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells

5 July 2024

96

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Mitogen-activated 3p kinase is active in the nucleus

5 July 2024

97

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways

5 July 2024

98

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

DCX, a new mediator of the JNK pathway

5 July 2024

100

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Signal transduction by the JNK group of MAP kinases

5 July 2024

101

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice

5 July 2024

102

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Role of extracellular signal regulated kinase 5 in neuronal survival.

5 July 2024

103

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Regulation of cellular functions by the ERK5 signalling pathway

5 July 2024

104

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MAPK signalling: ERK5 versus ERK1/2.

5 July 2024

105

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.

5 July 2024

106

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

5 July 2024

107

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Role of BMK1 in regulation of growth factor-induced cellular responses

5 July 2024

108

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.

5 July 2024

109

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

5 July 2024

110

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

WNK1 activates ERK5 by an MEKK2/3-dependent mechanism

5 July 2024

111

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

5 July 2024

112

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

5 July 2024

113

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

5 July 2024

114

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Identification and characterization of a novel MAP kinase kinase kinase, MLTK

5 July 2024

115

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Isolation of MEK5 and differential expression of alternatively spliced forms

5 July 2024

116

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains

5 July 2024

117

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.

5 July 2024

118

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation

5 July 2024

119

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase

5 July 2024

120

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.

5 July 2024

121

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1

5 July 2024

122

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

5 July 2024

123

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

5 July 2024

124

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults

5 July 2024

125

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domain

5 July 2024

126

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth

5 July 2024

127

1 reference

https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

ERK8, a new member of the mitogen-activated protein kinase family

5 July 2024

128

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Characterization of the reversible phosphorylation and activation of ERK8

5 July 2024

129

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

ERK7 is an autoactivated member of the MAPK family

5 July 2024

130

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway

5 July 2024

131

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https://api.crossref.org/works/10.1007/978-1-60761-795-2_1

Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.

5 July 2024

132

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Regulation of the activity and expression of ERK8 by DNA damage

5 July 2024

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Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction

5 July 2024

135

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ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5.

5 July 2024

136

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Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3

5 July 2024

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Proteasome- and p38-dependent regulation of ERK3 expression

5 July 2024

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Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

5 July 2024

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Scaffolding by ERK3 regulates MK5 in development

5 July 2024

140

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Does MK5 reconcile classical and atypical MAP kinases?

5 July 2024

141

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Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3

5 July 2024

142

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Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies

5 July 2024

143

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5 July 2024

144

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Conferring specificity on the ubiquitous Raf/MEK signalling pathway

5 July 2024

145

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Mechanisms of MAPK signalling specificity

5 July 2024

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MAPK signal specificity: the right place at the right time

5 July 2024

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The subcellular localization of MEK and ERK--a novel nuclear translocation signal (NTS) paves a way to the nucleus

5 July 2024

148

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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

5 July 2024

149

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A conserved docking motif in MAP kinases common to substrates, activators and regulators

5 July 2024

150

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

5 July 2024

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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

5 July 2024

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

5 July 2024

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Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.

5 July 2024

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The JIP family of MAPK scaffold proteins.

5 July 2024

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Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

5 July 2024

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ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.

5 July 2024

160

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Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo.

5 July 2024

161

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Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes

5 July 2024

162

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MAP kinase modules: many roads home.

5 July 2024

163

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Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

5 July 2024

164

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Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

5 July 2024

165

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Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

5 July 2024

166

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

5 July 2024

167

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Transcriptional regulation of IL-2 in health and autoimmunity

5 July 2024

168

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Control of MAP kinase signaling to the nucleus.

5 July 2024

169

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Identification and characterization of a general nuclear translocation signal in signaling proteins

5 July 2024

170

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Activation of the MAPK module from different spatial locations generates distinct system outputs

5 July 2024

171

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Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins

5 July 2024

172

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Total ERK1/2 activity regulates cell proliferation

5 July 2024

173

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Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?

5 July 2024

174

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JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.

5 July 2024

175

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Differential activation of the JNK signal pathway by UV irradiation and glucose deprivation

5 July 2024

176

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Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

5 July 2024

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The MAPK signaling cascade

5 July 2024

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The ERK cascade: a prototype of MAPK signaling

5 July 2024

179

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Phosphatase and feedback regulation of Raf-1 signaling

5 July 2024

180

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Knockdown of B-Raf impairs spindle formation and the mitotic checkpoint in human somatic cells

5 July 2024

181

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Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation

5 July 2024

182

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Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors

5 July 2024

183

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A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal

5 July 2024

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Current protocols in cell biology

5 July 2024

185

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

5 July 2024

186

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An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

5 July 2024

187

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Essential role for ERK2 mitogen-activated protein kinase in placental development

5 July 2024

188

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Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

5 July 2024

189

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The MAP kinase pathway is required for entry into mitosis and cell survival.

5 July 2024

190

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ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially.

5 July 2024

191

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Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels

5 July 2024

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ERK1c regulates Golgi fragmentation during mitosis

5 July 2024

193

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Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein

5 July 2024

194

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Differential Role of MEK5α and MEK5β in BMK1/ERK5 Activation

5 July 2024

195

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Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

5 July 2024

196

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Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-kappaB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway

5 July 2024

197

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Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase

5 July 2024

198

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

5 July 2024

199

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Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development

5 July 2024

200

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

5 July 2024

201

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MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway

5 July 2024

202

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NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis

5 July 2024

203

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NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

5 July 2024

204

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Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily

5 July 2024

205

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Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

5 July 2024

206

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

5 July 2024

207

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

5 July 2024

208

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SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

5 July 2024

209

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Induction of apoptosis by SLK, a Ste20-related kinase

5 July 2024

210

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TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

5 July 2024

211

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

5 July 2024

212

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MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5

5 July 2024

213

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Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

5 July 2024

214

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Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain

5 July 2024

215

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Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

5 July 2024

216

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Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

5 July 2024

217

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Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

5 July 2024

218

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The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

5 July 2024

219

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MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

5 July 2024

220

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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

5 July 2024

221

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Mixed-lineage kinase control of JNK and p38 MAPK pathways

5 July 2024

222

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Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro

5 July 2024

223

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Isotype-specific functions of Raf kinases

5 July 2024

224

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Regulation of the MAP kinase cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP

5 July 2024

225

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A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

5 July 2024

226

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Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

5 July 2024

227

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Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain

5 July 2024

228

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The protein kinase complement of the human genome

5 July 2024

229

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An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

5 July 2024

231

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Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel

5 July 2024

232

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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

5 July 2024

233

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

5 July 2024

234

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A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation

5 July 2024

235

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Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages

5 July 2024

236

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A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases

5 July 2024

237

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Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase

5 July 2024

238

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Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.

5 July 2024

239

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RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation

5 July 2024

240

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Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum

5 July 2024

241

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5 July 2024

Identifiers

1 reference

23 August 2017

1 reference