GRK2 as a novel gene therapy target in heart failure. (Q37783642)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20800067 AND SRC:MED&resulttype=core&format=json

13 February 2020

title

GRK2 as a novel gene therapy target in heart failure (English)

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13 February 2020

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1

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13 February 2020

Anastasios Lymperopoulos

series ordinal

2

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13 February 2020

Dario Leosco

series ordinal

3

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13 February 2020

author name string

Walter J Koch

series ordinal

4

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13 February 2020

publication date

25 August 2010

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Journal of Molecular and Cellular Cardiology

13 February 2020

published in

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13 February 2020

volume

50

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13 February 2020

issue

5

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13 February 2020

page(s)

785-792

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Comparative cardiac gene delivery of adeno-associated virus serotypes 1-9 reveals that AAV6 mediates the most efficient transduction in mouse heart

13 February 2020

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New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy

6 September 2017

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Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue

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6 September 2017

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6 September 2017

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The β-adrenergic receptor kinase in heart failure

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure

6 September 2017

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Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

6 September 2017

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In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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The development of positive inotropic agents for chronic heart failure: how have we gone astray?

6 September 2017

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Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

6 September 2017

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6 September 2017

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Beta-adrenoceptors in cardiac disease

6 September 2017

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14 September 2017

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The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase

28 September 2017

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

23 June 2018

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Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice

23 June 2018

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Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase

23 June 2018

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Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure

23 June 2018

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Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure.

1 September 2018

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Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling

1 September 2018

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Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading

1 September 2018

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Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure

1 September 2018

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Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding

1 September 2018

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Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes

1 September 2018

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Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy

1 September 2018

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Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats

1 September 2018

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Right ventricular gene therapy with a beta-adrenergic receptor kinase inhibitor improves survival after pulmonary artery banding

1 September 2018

1 reference

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Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor

1 September 2018

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Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1

1 September 2018

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Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure

7 January 2021

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Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

7 January 2021

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Expression of GRK2 is increased in the left ventricles of cardiomyopathic hamsters

7 January 2021

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Activation of beta-adrenergic receptor kinase during myocardial ischemia

7 January 2021

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Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure

7 January 2021

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In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function

7 January 2021

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Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1)

7 January 2021

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Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure

7 January 2021

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10.1016/J.YJMCC.2010.08.014

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20800067 AND SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20800067 AND SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

20800067

1 reference