Mechanisms of cryptococcal virulence and persistence (Q37781066)

23 August 2017

title

Mechanisms of cryptococcal virulence and persistence (English)

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23 August 2017

1

Michal A Olszewski

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23 August 2017

3

Gary B Huffnagle

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23 August 2017

Yanmei Zhang

2

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23 August 2017

publication date

1 August 2010

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23 August 2017

number of pages

20

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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23 August 2017

volume

5

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23 August 2017

issue

8

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23 August 2017

page(s)

1269-1288

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HIV-associated cryptococcal meningitis.

23 August 2017

cites work

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Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

21 January 2018

1 reference

Cryptococcosis in human immunodeficiency virus-negative patients in the era of effective azole therapy

21 January 2018

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Pulmonary cryptococcosis in patients without HIV infection: factors associated with disseminated disease

21 January 2018

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Disseminated pulmonary infection due to Cryptococcus neoformans in a non immunocompromised patient

21 January 2018

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Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China

21 January 2018

1 reference

A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)

21 January 2018

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Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997-2002): epidemiology, microbiology and histopathology

21 January 2018

1 reference

Cryptococcus gattii: An Emerging Cause of Fungal Disease in North America

21 January 2018

1 reference

Drug resistance in Cryptococcus neoformans.

21 January 2018

1 reference

Characterization of heteroresistance to fluconazole among clinical isolates of Cryptococcus neoformans

21 January 2018

1 reference

Antifungal drug susceptibility of Cryptococcus neoformans from clinical sources in Nairobi, Kenya

21 January 2018

1 reference

Combination of amphotericin B with flucytosine is active in vitro against flucytosine-resistant isolates of Cryptococcus neoformans

21 January 2018

1 reference

The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants

21 January 2018

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Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum

21 January 2018

1 reference

Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals

21 January 2018

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Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis

21 January 2018

1 reference

21 January 2018

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Pulmonary cryptococcosis and Capillaria aerophila infection in an FIV-positive cat.

21 January 2018

1 reference

Elucidating the pathogenesis of spores from the human fungal pathogen Cryptococcus neoformans

21 January 2018

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Spores as infectious propagules of Cryptococcus neoformans

21 January 2018

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Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides

21 January 2018

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Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway

21 January 2018

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MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans.

21 January 2018

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Opsonic requirements for dendritic cell-mediated responses to Cryptococcus neoformans

21 January 2018

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Cryptococcus neoformans activates bone marrow-derived conventional dendritic cells rather than plasmacytoid dendritic cells and down-regulates macrophages

21 January 2018

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Differential effect of Cryptococcus neoformans on the production of IL-12p40 and IL-10 by murine macrophages stimulated with lipopolysaccharide and gamma interferon

21 January 2018

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Cryptococcus neoformans capsular glucuronoxylomannan induces expression of fas ligand in macrophages

21 January 2018

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The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system

21 January 2018

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Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity.

21 January 2018

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Cryptococcus neoformans enters the endolysosomal pathway of dendritic cells and is killed by lysosomal components

21 January 2018

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Perforin-dependent cryptococcal microbicidal activity in NK cells requires PI3K-dependent ERK1/2 signaling.

21 January 2018

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Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis

21 January 2018

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Capsule enlargement in Cryptococcus neoformans confers resistance to oxidative stress suggesting a mechanism for intracellular survival

21 January 2018

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Th1-Th2 cytokine kinetics in the bronchoalveolar lavage fluid of mice infected with Cryptococcus neoformans of different virulences

21 January 2018

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Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response

21 January 2018

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Enhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection.

21 January 2018

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Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection

21 January 2018

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Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection.

21 January 2018

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In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection

21 January 2018

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Regulatory effects of macrophage inflammatory protein 1alpha/CCL3 on the development of immunity to Cryptococcus neoformans depend on expression of early inflammatory cytokines.

21 January 2018

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CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection

21 January 2018

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Distinct compartmentalization of CD4 T-cell effector function versus proliferative capacity during pulmonary cryptococcosis

21 January 2018

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Cytokine signaling regulates the outcome of intracellular macrophage parasitism by Cryptococcus neoformans

21 January 2018

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Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99

21 January 2018

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Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model

21 January 2018

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Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis

21 January 2018

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Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain

21 January 2018

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Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

21 January 2018

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Instruction, selection, or tampering with the odds?

21 January 2018

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Functional diversity of helper T lymphocytes

21 January 2018

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Generation of antifungal effector CD8 T cells in the absence of CD4 T cells during Cryptococcus neoformans infection

21 January 2018

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A gene-dosage effect for interleukin-4 receptor alpha-chain expression has an impact on Th2-mediated allergic inflammation during bronchopulmonary mycosis

21 January 2018

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An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia

21 January 2018

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Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection

21 January 2018

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Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung

21 January 2018

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Characterization of pathogenic constituents of Cryptococcus neoformans strains

21 January 2018

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Intersection of fungal fitness and virulence in Cryptococcus neoformans

21 January 2018

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Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents

21 January 2018

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Induction of Capsule Growth inCryptococcus neoformansby Mammalian Serum and CO2

21 January 2018

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Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier

21 January 2018

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Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection

21 January 2018

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Calcineurin is required for virulence of Cryptococcus neoformans

21 January 2018

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Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans

21 January 2018

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Cryptococcus neoformans, a fungus under stress

21 January 2018

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Signalling pathways in the pathogenesis of Cryptococcus

21 January 2018

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Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans

21 January 2018

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Cryptococcal lipid metabolism: phospholipase B1 is implicated in transcellular metabolism of macrophage-derived lipids

21 January 2018

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Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence

21 January 2018

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Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide

21 January 2018

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Regulation of cryptococcal capsular polysaccharide by iron

21 January 2018

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Role of ferroxidases in iron uptake and virulence of Cryptococcus neoformans.

21 January 2018

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Experimental modulation of capsule size in Cryptococcus neoformans

21 January 2018

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The presence of capsule in Cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus.

21 January 2018

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Modulation of C5aR expression on human neutrophils by encapsulated and acapsular Cryptococcus neoformans

21 January 2018

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Interdependency of interleukin-10 and interleukin-12 in regulation of T-cell differentiation and effector function of monocytes in response to stimulation with Cryptococcus neoformans

21 January 2018

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Cryptococcal polysaccharides induce L-selectin shedding and tumor necrosis factor receptor loss from the surface of human neutrophils

21 January 2018

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Cryptococcal glucuronoxylomannan inhibits adhesion of neutrophils to stimulated endothelium in vitro by affecting both neutrophils and endothelial cells

21 January 2018

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Cryptococcal glucuronoxylomannan interferes with neutrophil rolling on the endothelium

21 January 2018

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The efficacy of complement-mediated phagocytosis of Cryptococcus neoformans is dependent on the location of C3 in the polysaccharide capsule and involves both direct and indirect C3-mediated interactions.

21 January 2018

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Phagocytosis and protein processing are required for presentation of Cryptococcus neoformans mitogen to T lymphocytes

21 January 2018

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Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans

21 January 2018

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App1: an antiphagocytic protein that binds to complement receptors 3 and 2.

21 January 2018

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Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival

21 January 2018

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Microbial immune suppression mediated by direct engagement of inhibitory Fc receptor

21 January 2018

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The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes

21 January 2018

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Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection

21 January 2018

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The Skn7 response regulator of Cryptococcus neoformans is involved in oxidative stress signalling and augments intracellular survival in endothelium.

21 January 2018

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Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.

21 January 2018

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Evidence of a role for monocytes in dissemination and brain invasion by Cryptococcus neoformans

21 January 2018

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Antibody action after phagocytosis promotes Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilm-like microcolony formation

21 January 2018

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Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans

21 January 2018

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Cell wall targeting of laccase of Cryptococcus neoformans during infection of mice

21 January 2018

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Laccase expression in murine pulmonary Cryptococcus neoformans infection

21 January 2018

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Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor

21 January 2018

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Role of laccase in the biology and virulence of Cryptococcus neoformans

21 January 2018

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Vesicle-associated melanization in Cryptococcus neoformans

21 January 2018

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Lipid rafts in Cryptococcus neoformans concentrate the virulence determinants phospholipase B1 and Cu/Zn superoxide dismutase

21 January 2018

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Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans

21 January 2018

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The role of laccase in prostaglandin production by Cryptococcus neoformans

21 January 2018

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Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase

21 January 2018

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Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation.

21 January 2018

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Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase

21 January 2018

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Antioxidant function of fungal melanin

21 January 2018

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Effect of melanization upon porosity of the cryptococcal cell wall

21 January 2018

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The Cryptococcus neoformans catalase gene family and its role in antioxidant defense

21 January 2018

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Contribution of the myeloperoxidase-dependent oxidative system to host defence against Cryptococcus neoformans

21 January 2018

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Characterization of Cu,Zn superoxide dismutase (SOD1) gene knock-out mutant of Cryptococcus neoformans var. gattii: role in biology and virulence

21 January 2018

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Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages

21 January 2018

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Characterization of Cryptococcus neoformans variety gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence

21 January 2018

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Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth

21 January 2018

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Two glutathione peroxidases in the fungal pathogen Cryptococcus neoformans are expressed in the presence of specific substrates.

21 January 2018

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Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans.

21 January 2018

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Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages

21 January 2018

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IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis

21 January 2018

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Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation

21 January 2018

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Expulsion of live pathogenic yeast by macrophages

21 January 2018

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Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages

21 January 2018

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Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway

21 January 2018

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Capsular polysaccharide induction of apoptosis by intrinsic and extrinsic mechanisms.

21 January 2018

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Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production

21 January 2018

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Mycobacterium bovis BCG urease attenuates major histocompatibility complex class II trafficking to the macrophage cell surface

21 January 2018

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The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection is associated with pleiotropic differences in the immune response

21 January 2018

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IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans

21 January 2018

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TH17 cells and regulatory T cells in primary immunodeficiency diseases

21 January 2018

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Serologic evidence for reactivation of cryptococcosis in solid-organ transplant recipients

21 January 2018

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Immunologic homeostasis during infection: coexistence of strong pulmonary cell-mediated immunity to secondary Cryptococcus neoformans infection while the primary infection still persists at low levels in the lungs

21 January 2018

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Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence.

21 January 2018

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Extracellular vesicles from Cryptococcus neoformans modulate macrophage functions

21 January 2018

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Towards a vaccine for Cryptococcus neoformans: principles and caveats.

21 January 2018

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The capsule of the fungal pathogen Cryptococcus neoformans

21 January 2018

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Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion

21 January 2018

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Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier

21 January 2018

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Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells

21 January 2018

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Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans

21 January 2018

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Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia

21 January 2018

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Phenotypic switching in a Cryptococcus neoformans variety gattii strain is associated with changes in virulence and promotes dissemination to the central nervous system

21 January 2018

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Surface-associated plasminogen binding of Cryptococcus neoformans promotes extracellular matrix invasion

21 January 2018

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Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain.

21 January 2018

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Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation

21 January 2018

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Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans

21 January 2018

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Role of CD4 T cells in a protective immune response against Cryptococcus neoformans in the central nervous system

21 January 2018

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Protection from direct cerebral cryptococcus infection by interferon-gamma-dependent activation of microglial cells

21 January 2018

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Immunomodulation with CD40 stimulation and interleukin-2 protects mice from disseminated cryptococcosis

21 January 2018

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The ABC transporter-encoding gene AFR1 affects the resistance of Cryptococcus neoformans to microglia-mediated antifungal activity by delaying phagosomal maturation

21 January 2018

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CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence

21 January 2018

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Urease as a virulence factor in experimental cryptococcosis

21 January 2018

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Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole

21 January 2018

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Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans

21 January 2018

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Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes

21 January 2018

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Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence

21 January 2018

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A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans

21 January 2018

1 reference

Prosthetic hip infection due to Cryptococcus neoformans: case report

21 January 2018

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Biofilm formation by Cryptococcus neoformans under distinct environmental conditions

21 January 2018

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Susceptibility of Cryptococcus neoformans biofilms to antifungal agents in vitro

21 January 2018

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Cryptococcus neoformans cells in biofilms are less susceptible than planktonic cells to antimicrobial molecules produced by the innate immune system

21 January 2018

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TheCryptococcus neoformans cap10â andcap59â mutant strains, affected in glucuronoxylomannan synthesis, differentially activate human dendritic cells

21 January 2018

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Monocyte dysfunction in patients with acquired immunodeficiency syndrome (AIDS) versus Cryptococcus neoformans

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FMB.10.93

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23 August 2017

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