Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. (Q37769931)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

review article

1 reference

title

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

main subject

cardiovascular disease

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

author name string

Ming Dong

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

Bryan P Yan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

James K Liao

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

Yat-Yin Lam

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

Cheuk-Man Yu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

publication date

25 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

issue

15-16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

622-629

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm

7 February 2020

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Rho-kinase is an important therapeutic target in cardiovascular medicine

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Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor

22 August 2017

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Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension

22 August 2017

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Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo

22 August 2017

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Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment

22 August 2017

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Rho and Rho kinase are involved in parathyroid hormone-stimulated protein kinase C alpha translocation and IL-6 promoter activity in osteoblastic cells

22 August 2017

1 reference

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Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

22 August 2017

1 reference

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Therapy of erectile dysfunction: potential future treatments

22 August 2017

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Ca2 sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

22 August 2017

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Inflammation in atherosclerosis

22 August 2017

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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

22 August 2017

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The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization

22 August 2017

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The novel and specific Rho-kinase inhibitor (S)-( )-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

22 August 2017

1 reference

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Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

22 August 2017

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Potential use of HMG-CoA reductase inhibitors for osteoporosis

22 August 2017

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Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases

22 August 2017

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Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina

22 August 2017

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Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

22 August 2017

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Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure

22 August 2017

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

22 August 2017

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Citron, a Rho target that affects contractility during cytokinesis

22 August 2017

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Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta

22 August 2017

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H-series protein kinase inhibitors and potential clinical applications

22 August 2017

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Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

22 August 2017

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22 August 2017

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Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

22 August 2017

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

22 August 2017

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

22 August 2017

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The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

22 August 2017

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Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase

22 August 2017

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22 August 2017

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Rho kinases play an obligatory role in vertebrate embryonic organogenesis

22 August 2017

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Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina

22 August 2017

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6 September 2017

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Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells

6 September 2017

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The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

14 September 2017

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14 September 2017

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Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells

14 September 2017

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Monitoring the cellular effects of HMG-CoA reductase inhibitors in vitro and ex vivo

14 September 2017

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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins

14 September 2017

1 reference

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Potential role of the adventitia in arteritis and atherosclerosis

28 September 2017

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Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system

28 September 2017

1 reference

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Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction

23 June 2018

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Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases

23 June 2018

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Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells

23 June 2018

1 reference

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Transformation mediated by RhoA requires activity of ROCK kinases

23 June 2018

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

23 June 2018

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Coronary Spasm: Clinical Features and Pathogenesis

23 June 2018

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Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients

23 June 2018

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The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes

1 September 2018

1 reference

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RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling

1 September 2018

1 reference

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The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation

1 September 2018

1 reference

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Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons

1 September 2018

1 reference

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Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells

1 September 2018

1 reference

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Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil

1 September 2018

1 reference

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Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial

1 September 2018

1 reference

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Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway

1 September 2018

1 reference

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Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial

1 September 2018

1 reference

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Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension

1 September 2018

1 reference

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Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure

1 September 2018

1 reference

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Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow

1 September 2018

1 reference

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Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report

1 September 2018

1 reference

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Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord

1 September 2018

1 reference

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Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Long-Term Treatment With a Specific Rho-Kinase Inhibitor Suppresses Cardiac Allograft Vasculopathy in Mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Long-Term Inhibition of Rho-Kinase Suppresses Neointimal Formation After Stent Implantation in Porcine Coronary Arteries: Involvement of Multiple Mechanisms

1 September 2018

1 reference

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Rho-associated protein kinase contributes to early atherosclerotic lesion formation in mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Rho-kinase inhibitors: pharmacomodulations on the lead compound Y-32885.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Antiischemic properties of fasudil in experimental models of vasospastic angina

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807099

Enhanced Myosin Light Chain Phosphorylations as a Central Mechanism for Coronary Artery Spasm in a Swine Model With Interleukin-1β

1 September 2018

1 reference

12 December 2020

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

1 reference

12 December 2020

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration

1 reference

12 December 2020

Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase

1 reference

12 December 2020

Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris

1 reference

12 December 2020

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

1 reference

12 December 2020

Differential effects of short-term lipid lowering with ezetimibe and statins on endothelial function in patients with CAD: clinical evidence for ‘pleiotropic’ functions of statin therapy

1 reference

12 December 2020

Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities

1 reference

12 December 2020

Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice

1 reference

12 December 2020

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats

1 reference

12 December 2020

Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium

1 reference

12 December 2020

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1 reference

12 December 2020

Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm

1 reference

12 December 2020

Activation of RhoA by thrombin in endothelial hyperpermeability: role of Rho kinase and protein tyrosine kinases

1 reference

12 December 2020

Hemorheological abnormalities in experimental cerebral ischemia and effects of protein kinase inhibitor on blood fluidity

1 reference

12 December 2020

Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo

1 reference

12 December 2020

Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells

1 reference

12 December 2020

Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation

1 reference

12 December 2020

Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries

1 reference

12 December 2020

10.1016/J.DRUDIS.2010.06.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20601092 AND SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

20601092

1 reference