Phosphoinositide signalling in cancer: beyond PI3K and PTEN. (Q37736257)

22 August 2017

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title

Phosphoinositide signalling in cancer: beyond PI3K and PTEN. (English)

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22 August 2017

Tom D Bunney

1

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22 August 2017

Matilda Katan

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

1 May 2010

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22 August 2017

published in

Nature Reviews Cancer

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22 August 2017

volume

10

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22 August 2017

issue

5

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22 August 2017

page(s)

342-352

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BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

22 August 2017

cites work

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cDNA Microarray Analysis of Gene Expression Profiles Associated with Cervical Cancer

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Multiple roles of phosphoinositide-specific phospholipase C isozymes

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New insights into the families of PLC enzymes: looking back and going forward

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Organelle identity and the signposts for membrane traffic

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Phosphoinositides in cell regulation and membrane dynamics

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PDK1, the master regulator of AGC kinase signal transduction

31 March 2020

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The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.

31 March 2020

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Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.

31 March 2020

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Phosphoinositide regulation of the actin cytoskeleton

31 March 2020

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Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking

31 March 2020

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

31 March 2020

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

31 March 2020

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Understanding PTEN regulation: PIP2, polarity and protein stability

31 March 2020

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The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

31 March 2020

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The role of phosphatases in inositol signaling reactions

31 March 2020

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Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

31 March 2020

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Phosphoinositides as regulators of membrane trafficking in health and disease.

31 March 2020

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Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling

31 March 2020

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Lipid signalling in disease.

31 March 2020

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PI3K pathway alterations in cancer: variations on a theme

31 March 2020

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Targeting the phosphoinositide 3-kinase pathway in cancer

31 March 2020

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

31 March 2020

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

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High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

31 March 2020

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Oncogenic mutations of PIK3CA in human cancers

31 March 2020

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

31 March 2020

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

31 March 2020

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Portrait of PTEN: messages from mutant mice.

31 March 2020

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PTEN and the PI3-kinase pathway in cancer

31 March 2020

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PTEN: its deregulation and tumorigenesis.

31 March 2020

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

31 March 2020

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PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.

31 March 2020

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Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

31 March 2020

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Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes

31 March 2020

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Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

31 March 2020

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Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle

31 March 2020

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Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)

31 March 2020

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Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

31 March 2020

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Activation of SHIP via a small molecule agonist kills multiple myeloma cells.

31 March 2020

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Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.

31 March 2020

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Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

31 March 2020

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Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover.

31 March 2020

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

31 March 2020

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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

31 March 2020

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In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling

31 March 2020

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Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling

31 March 2020

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Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer

31 March 2020

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A molecular signature of metastasis in primary solid tumors

31 March 2020

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Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

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The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

31 March 2020

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Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death

31 March 2020

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Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

31 March 2020

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Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene.

31 March 2020

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High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

31 March 2020

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Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer

31 March 2020

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Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

31 March 2020

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Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.

31 March 2020

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Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.

31 March 2020

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A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.

31 March 2020

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PIP(2) and proteins: interactions, organization, and information flow

31 March 2020

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PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

31 March 2020

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Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

31 March 2020

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Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.

31 March 2020

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Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

31 March 2020

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Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

31 March 2020

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31 March 2020

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Making and breaking contacts: the cellular biology of cadherin regulation

31 March 2020

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Molecular architecture and functional model of the endocytic AP2 complex

31 March 2020

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Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin

31 March 2020

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Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells

31 March 2020

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PIP5KI gamma is required for cardiovascular and neuronal development

31 March 2020

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

31 March 2020

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E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer

31 March 2020

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The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion

31 March 2020

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Cell polarity in development and cancer.

31 March 2020

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Structural and mechanistic aspects of phospholipase Cgamma regulation

31 March 2020

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Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

31 March 2020

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Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin

31 March 2020

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The cofilin pathway in breast cancer invasion and metastasis

31 March 2020

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Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells

31 March 2020

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EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

31 March 2020

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Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

31 March 2020

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Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering

31 March 2020

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Mapping the Phosphoinositide-Binding Site on Chick Cofilin Explains How PIP2 Regulates the Cofilin-Actin Interaction

31 March 2020

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Cofilin promotes actin polymerization and defines the direction of cell motility

31 March 2020

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Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis

31 March 2020

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Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration

31 March 2020

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PLCgamma1 is essential for early events in integrin signalling required for cell motility

31 March 2020

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Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.

31 March 2020

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Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor

31 March 2020

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Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.

31 March 2020

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Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas

31 March 2020

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Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.

31 March 2020

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PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors

31 March 2020

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Phospholipase Cgamma1 is required for metastasis development and progression

31 March 2020

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Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2 entry

31 March 2020

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Characterization of phospholipase C gamma enzymes with gain-of-function mutations

31 March 2020

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ErbB receptors and signaling pathways in cancer

31 March 2020

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Phospholipase C epsilon: linking second messengers and small GTPases

31 March 2020

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Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

31 March 2020

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Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester

31 March 2020

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31 March 2020

Inflammation and cancer

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Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/ ) mice through augmentation of inflammation and angiogenesis.

31 March 2020

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Class 1A PI3K regulates vessel integrity during development and tumorigenesis

31 March 2020

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Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

31 March 2020

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Focus on myeloproliferative diseases and myelodysplastic syndromes

31 March 2020

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Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.

31 March 2020

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The regulation of cell motility and chemotaxis by phospholipid signaling

31 March 2020

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Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.

31 March 2020

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12 December 2020

Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma

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12 December 2020

Deletions on chromosome 4 in sporadic and BRCA mutated tumors and association with pathological variables

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12 December 2020

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

1 reference

12 December 2020

Expression profiling and subtype-specific expression of stomach cancer.

1 reference

12 December 2020

Type II PtdInsP kinases: location, regulation and function

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12 December 2020

Structure, function, and biology of SHIP proteins

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12 December 2020

SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells.

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12 December 2020

Mutation analysis of SHIP gene in acute leukemia

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12 December 2020

Identifiers

DOI

10.1038/NRC2842

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22 August 2017

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