The role of sphingolipid signalling in diabetes‑associated pathologies (Review). (Q37711953)

22 August 2017

4 references

14 March 2019

24 March 2019

19 November 2019

26 August 2020

The role of sphingolipid signalling in diabetes‑associated pathologies (Review). (English)

1 reference

22 August 2017

4 references

14 March 2019

24 March 2019

19 November 2019

26 August 2020

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19 November 2019

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Mei Li Ng

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Carol Wadham

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Carol Wadham

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Olga A. Sukocheva

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Olga A Sukocheva

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3

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language of work or name

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11 January 2017

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PMC publication ID

5358714

International Journal of Molecular Medicine

22 August 2017

1 February 2017

4 references

14 March 2019

24 March 2019

19 November 2019

26 August 2020

5 references

22 August 2017

14 March 2019

24 March 2019

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2

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Creative Commons Attribution-NonCommercial-NoDerivatives

22 August 2017

4 references

14 March 2019

24 March 2019

19 November 2019

26 August 2020

on focus list of Wikimedia project

ScienceSource

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Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

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Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity

23 August 2017

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The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

23 August 2017

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Therapeutic approach for type 1 diabetes mellitus using the novel immunomodulator FTY720 (fingolimod) in combination with once-daily injection of insulin glargine in non-obese diabetic mice

23 August 2017

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The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus.

23 August 2017

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Sphingosine kinase 1 regulates adipose proinflammatory responses and insulin resistance

23 August 2017

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Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes

23 August 2017

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Effects of inhibition of serine palmitoyltransferase (SPT) and sphingosine kinase 1 (SphK1) on palmitate induced insulin resistance in L6 myotubes

23 August 2017

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Sphingosine 1-phosphate signalling

23 August 2017

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A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.

23 August 2017

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Sphingolipids in obesity, type 2 diabetes, and metabolic disease

23 August 2017

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High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate

23 August 2017

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Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction

23 August 2017

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Effect of sphingosine kinase 1 inhibition on blood pressure

23 August 2017

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Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity

23 August 2017

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Sphingolipid signaling in metabolic disorders

23 August 2017

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Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

23 August 2017

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FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease

23 August 2017

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Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress

23 August 2017

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Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.

23 August 2017

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Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells

23 August 2017

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FTY720 Normalizes Hyperglycemia by Stimulating β-Cell in Vivo Regeneration in db/db Mice through Regulation of Cyclin D3 and p57KIP2

23 August 2017

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Sphingosine-1-phosphate signaling and its role in disease

23 August 2017

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Sphingosine Kinase-1 Pathway Mediates High Glucose-Induced Fibronectin Expression in Glomerular Mesangial Cells

23 August 2017

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The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

23 August 2017

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National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

23 August 2017

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Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease

23 August 2017

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Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells

23 August 2017

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The outs and the ins of sphingosine-1-phosphate in immunity

23 August 2017

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BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

23 August 2017

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

23 August 2017

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Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression

23 August 2017

1 reference

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Circulating sphingolipid biomarkers in models of type 1 diabetes

23 August 2017

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Extracellular and Intracellular Actions of Sphingosine-1-Phosphate

23 August 2017

1 reference

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Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells

23 August 2017

1 reference

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Residual microvascular risk in diabetes: unmet needs and future directions

23 August 2017

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Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species

23 August 2017

1 reference

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Prohibitin and mitochondrial biology

23 August 2017

1 reference

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Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

23 August 2017

1 reference

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Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation?

23 August 2017

1 reference

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A lipid binding domain in sphingosine kinase 2

23 August 2017

1 reference

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Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

23 August 2017

1 reference

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Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3.

23 August 2017

1 reference

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Sphingosine kinase regulation and cardioprotection

23 August 2017

1 reference

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Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization

23 August 2017

1 reference

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Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches

23 August 2017

1 reference

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New insights into the role of HDL as an anti-inflammatory agent in the prevention of cardiovascular disease

23 August 2017

1 reference

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Autocrine and paracrine roles of sphingosine-1-phosphate

23 August 2017

1 reference

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Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2.

23 August 2017

1 reference

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HDL and its sphingosine-1-phosphate content in cardioprotection

23 August 2017

1 reference

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Regulation and functional roles of sphingosine kinases

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Life and death decisions of the pancreatic beta-cell: the role of fatty acids

23 August 2017

1 reference

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Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases

23 August 2017

1 reference

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Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis

23 August 2017

1 reference

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Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor

23 August 2017

1 reference

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Cellular signalling by sphingosine kinase and sphingosine 1-phosphate.

23 August 2017

1 reference

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Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide

23 August 2017

1 reference

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The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function

23 August 2017

1 reference

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Renal fibrosis: new insights into the pathogenesis and therapeutics

23 August 2017

1 reference

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Essential role for sphingosine kinases in neural and vascular development

23 August 2017

1 reference

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Insulin resistance, diabetes and cardiovascular risk: approaches to treatment

23 August 2017

1 reference

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Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines

23 August 2017

1 reference

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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

23 August 2017

1 reference

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Sphingosine-1-phosphate: an enigmatic signalling lipid

23 August 2017

1 reference

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Report of the expert committee on the diagnosis and classification of diabetes mellitus

23 August 2017

1 reference

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Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

23 August 2017

1 reference

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Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association

23 August 2017

1 reference

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Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

23 August 2017

1 reference

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Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances

23 August 2017

1 reference

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Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy.

6 September 2017

1 reference

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S1P signaling: new therapies and opportunities

6 September 2017

1 reference

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Vascular oxidative stress, nitric oxide and atherosclerosis

6 September 2017

1 reference

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Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival.

6 September 2017

1 reference

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Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.

6 September 2017

1 reference

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The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function.

6 September 2017

1 reference

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Translational aspects of sphingosine 1-phosphate biology

6 September 2017

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Regulation of sphingosine kinase and sphingolipid signaling.

6 September 2017

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A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

6 September 2017

1 reference

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Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic beta-cells

14 September 2017

1 reference

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Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.

14 September 2017

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Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet beta-cells.

14 September 2017

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Deactivation of sphingosine kinase 1 by protein phosphatase 2A.

14 September 2017

1 reference

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Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine kinase type 2 activation by ERK-mediated phosphorylation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

The mechanism of membrane targeting of human sphingosine kinase 1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Overexpression of sphingosine kinase 1 in liver reduces triglyceride content in mice fed a low but not high-fat diet.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Selective inhibition of sphingosine kinase-1 protects adipose tissue against LPS-induced inflammatory response in Zucker diabetic fatty rats

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine-1-phosphate receptor 1 transmits estrogens' effects in endothelial cells.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic β-cell death in diet-induced obese mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine kinase activation mediates ischemic preconditioning in murine heart

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5358714

Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28075451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28075451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3892/IJMM.2017.2855

1 reference

22 August 2017

1 reference

PMC publication ID

5358714

22 August 2017

PubMed publication ID

28075451

1 reference

PMC publication ID

5358714