Flotillins in receptor tyrosine kinase signaling and cancer. (Q37693615)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24709906 AND SRC:MED&resulttype=core&format=json

13 March 2020

title

Flotillins in receptor tyrosine kinase signaling and cancer (English)

1 reference

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13 March 2020

4

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13 March 2020

author name string

Antje Banning

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24709906 AND SRC:MED&resulttype=core&format=json

13 March 2020

Nina Kurrle

series ordinal

2

1 reference

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13 March 2020

Melanie Meister

series ordinal

3

1 reference

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13 March 2020

publication date

19 February 2014

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13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24709906 AND SRC:MED&resulttype=core&format=json

13 March 2020

volume

3

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13 March 2020

issue

1

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13 March 2020

page(s)

129-149

1 reference

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Creative Commons Attribution 4.0 International

13 March 2020

copyright license

start time

19 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cells

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Reggies/flotillins regulate E-cadherin–mediated cell contact formation by affecting EGFR trafficking

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Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment

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Flotillins are involved in the polarization of primitive and mature hematopoietic cells

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Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod

23 August 2017

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Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase

23 August 2017

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The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

23 August 2017

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Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

23 August 2017

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23 August 2017

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Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein

23 August 2017

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The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase

23 August 2017

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ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

23 August 2017

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High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma

23 August 2017

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Flotillin-1 regulates IgE receptor-mediated signaling in rat basophilic leukemia (RBL-2H3) cells

23 August 2017

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Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells

23 August 2017

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23 August 2017

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Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells

23 August 2017

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23 August 2017

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Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation

23 August 2017

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Formation of membrane-bound ring complexes by prohibitins in mitochondria

23 August 2017

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Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1

23 August 2017

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Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis

23 August 2017

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

23 August 2017

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Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling

23 August 2017

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The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

23 August 2017

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Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions

23 August 2017

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PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle

23 August 2017

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Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation

23 August 2017

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Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling

23 August 2017

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Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2

23 August 2017

1 reference

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The sorbin homology domain: a motif for the targeting of proteins to lipid rafts

23 August 2017

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Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

23 August 2017

1 reference

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Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

23 August 2017

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Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

23 August 2017

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

23 August 2017

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Untangling the ErbB signalling network

23 August 2017

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Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals

23 August 2017

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Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts

23 August 2017

1 reference

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

23 August 2017

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Molecular portraits of human breast tumours

23 August 2017

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Potential involvement of FRS2 in insulin signaling

23 August 2017

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23 August 2017

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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

1 September 2018

1 reference

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The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe

23 August 2017

1 reference

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Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

23 August 2017

1 reference

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Oligomeric Nature of the Integral Membrane Protein Stomatin

23 August 2017

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

23 August 2017

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Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins

23 August 2017

1 reference

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

23 August 2017

1 reference

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

23 August 2017

1 reference

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Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model.

23 August 2017

1 reference

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Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.

6 September 2017

1 reference

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Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model

6 September 2017

1 reference

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Flotillins as regulators of ErbB2 levels in breast cancer

6 September 2017

1 reference

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Flotillin-1 promotes tumor necrosis factor-α receptor signaling and activation of NF-κB in esophageal squamous cell carcinoma cells.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Functional Aspects of Membrane Association of Reggie/Flotillin Proteins

6 September 2017

1 reference

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Knockdown of FLOT1 Impairs Cell Proliferation and Tumorigenicity in Breast Cancer through Upregulation of FOXO3a

6 September 2017

1 reference

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Revitalizing membrane rafts: new tools and insights

6 September 2017

1 reference

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Sphingomyelin-enriched microdomains at the Golgi complex

6 September 2017

1 reference

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The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines

6 September 2017

1 reference

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Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Membrane rafts play a crucial role in receptor activator of nuclear factor kappaB signaling and osteoclast function

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Activation of p38 mitogen-activated protein kinase by signaling through G protein-coupled receptors. Involvement of Gbetagamma and Galphaq/11 subunits

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Specific organ metastases of human melanoma cells injected into the arterial circulation of nude mice

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

The ERBB network: at last, cancer therapy meets systems biology.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins: convergent evolution of the SPFH domain

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Lipid raft-associated protein sorting in exosomes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3980747

Evolution of duplicated reggie genes in zebrafish and goldfish

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24709906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24709906

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/CELLS3010129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24709906 AND SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24709906 AND SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

24709906

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24709906 AND SRC:MED&resulttype=core&format=json