Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. (Q37691070)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393 AND SRC:MED&resulttype=core&format=json

8 March 2020

title

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease (English)

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8 March 2020

0 references

4

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8 March 2020

Mary J LaDu

5

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8 March 2020

author name string

Andrew B Wolf

1

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8 March 2020

Jon Valla

2

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8 March 2020

Guojun Bu

3

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8 March 2020

Richard J Caselli

7

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8 March 2020

Eric M Reiman

6

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8 March 2020

language of work or name

English

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publication date

3 September 2013

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Alzheimers Research & Therapy

8 March 2020

published in

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8 March 2020

volume

5

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8 March 2020

issue

5

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8 March 2020

page(s)

38

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Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

8 March 2020

cites work

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Apolipoprotein e sets the stage: response to injury triggers neuropathology

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APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease

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Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study

23 August 2017

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Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology

23 August 2017

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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

23 August 2017

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Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease

23 August 2017

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Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

23 August 2017

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Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

23 August 2017

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Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

23 August 2017

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Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

23 August 2017

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ApoE is required for maintenance of the dentate gyrus neural progenitor pool

23 August 2017

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Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge

23 August 2017

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Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

23 August 2017

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Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

23 August 2017

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Longitudinal modeling of frontal cognition in APOE ε4 homozygotes, heterozygotes, and noncarriers

23 August 2017

1 reference

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Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

23 August 2017

1 reference

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Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

23 August 2017

1 reference

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APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42

23 August 2017

1 reference

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

23 August 2017

1 reference

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Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

23 August 2017

1 reference

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ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype

23 August 2017

1 reference

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Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice

23 August 2017

1 reference

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APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging

23 August 2017

1 reference

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ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

23 August 2017

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GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice

23 August 2017

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Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

23 August 2017

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Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function

23 August 2017

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Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect

23 August 2017

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

23 August 2017

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Biophysical analysis of progressive C-terminal truncations of human apolipoprotein E4: insights into secondary structure and unfolding properties

23 August 2017

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APOE genotype-specific differences in the innate immune response

23 August 2017

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Functions and dysfunctions of mitochondrial dynamics

23 August 2017

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Microvascular injury and blood-brain barrier leakage in Alzheimer's disease

23 August 2017

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

23 August 2017

1 reference

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Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

23 August 2017

1 reference

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Apolipoprotein-mediated pathways of lipid antigen presentation

23 August 2017

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23 August 2017

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Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

23 August 2017

1 reference

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ApoE genotype accounts for the vast majority of AD risk and AD pathology

23 August 2017

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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

23 August 2017

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APOE genotype and cerebral blood flow in healthy young individuals

23 August 2017

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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

23 August 2017

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ApoE deficiency compromises the blood brain barrier especially after injury.

23 August 2017

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Apolipoprotein E: far more than a lipid transport protein

23 August 2017

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

23 August 2017

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Cholesterol metabolism in the brain

23 August 2017

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Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.

23 August 2017

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Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

23 August 2017

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

23 August 2017

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

23 August 2017

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Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

23 August 2017

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Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

23 August 2017

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Chylomicron remnant metabolism. Role of hepatic lipoprotein receptors in mediating uptake

23 August 2017

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Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

23 August 2017

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Apolipoprotein E in Alzheimer's disease and other neurological disorders

6 September 2017

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Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

6 September 2017

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Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

6 September 2017

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Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc

14 September 2017

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Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer

14 September 2017

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Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease

14 September 2017

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APOE genotype alters glial activation and loss of synaptic markers in mice

14 September 2017

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Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

28 September 2017

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The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

28 September 2017

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Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

28 September 2017

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Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

23 June 2018

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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

23 June 2018

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Hippocampal volume differences between healthy young apolipoprotein E ε2 and ε4 carriers

23 June 2018

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Identification of ApoE as an autocrine/paracrine factor that stimulates neural stem cell survival via MAPK/ERK signaling pathway

1 September 2018

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Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults

1 September 2018

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Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele

1 September 2018

1 reference

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Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells.

1 September 2018

1 reference

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Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

1 September 2018

1 reference

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Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment

1 September 2018

1 reference

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Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

1 September 2018

1 reference

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Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Apolipoprotein E isoform mediated regulation of nitric oxide release

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

CNS synaptogenesis promoted by glia-derived cholesterol

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Oxidative damage is the earliest event in Alzheimer disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Mitochondrial abnormalities in Alzheimer's disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979087

Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23998393

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23998393

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/ALZRT204

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393 AND SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

23998393

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23998393 AND SRC:MED&resulttype=core&format=json