Integrating Pharmacoproteomics into Early-Phase Clinical Development: State-of-the-Art, Challenges, and Recommendations (Q37691056)

22 August 2017

4 references

20 June 2019

19 September 2019

21 December 2019

25 November 2020

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Integrating Pharmacoproteomics into Early-Phase Clinical Development: State-of-the-Art, Challenges, and Recommendations (English)

1 reference

biomedical investigative technique

22 August 2017

1 reference

19 September 2019

1 reference

21 December 2019

1 reference

25 November 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28218733 AND SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Savita Nandal

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1

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13 June 2020

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English

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publication date

19 February 2017

5 references

International Journal of Molecular Sciences

22 August 2017

20 June 2019

19 September 2019

21 December 2019

25 November 2020

5 references

20 June 2019

19 September 2019

21 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28218733 AND SRC:MED&resulttype=core&format=json

13 June 2020

25 November 2020

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28218733 AND SRC:MED&resulttype=core&format=json

13 June 2020

issue

2

1 reference

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Creative Commons Attribution

13 June 2020

copyright license

4 references

20 June 2019

19 September 2019

21 December 2019

25 November 2020

0 references

Reverse Phase Protein Arrays-Quantitative Assessment of Multiple Biomarkers in Biopsies for Clinical Use

1 reference

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Pharmacometabolomics in Early-Phase Clinical Development.

23 August 2017

1 reference

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Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination

23 August 2017

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Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma

23 August 2017

1 reference

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A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.

23 August 2017

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Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.

23 August 2017

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Research participants' perceptions and views on consent for biobank research: a review of empirical data and ethical analysis

23 August 2017

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Application of molecular profiling in clinical trials for advanced metastatic cancers

23 August 2017

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First-in-man phase 1 clinical trial of gene therapy for advanced pancreatic cancer: safety, biodistribution, and preliminary clinical findings

23 August 2017

1 reference

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A draft map of the human proteome

23 August 2017

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Phase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associated breast or ovarian cancer with biomarker analyses

23 August 2017

1 reference

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Proteomic cancer biomarkers from discovery to approval: it's worth the effort

23 August 2017

1 reference

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Phase II trial of sorafenib and erlotinib in advanced pancreatic cancer

23 August 2017

1 reference

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Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously treated non-small cell lung cancer

23 August 2017

1 reference

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Timing and completeness of trial results posted at ClinicalTrials.gov and published in journals

23 August 2017

1 reference

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Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration

23 August 2017

1 reference

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Pharmacogenomics in early-phase clinical development

23 August 2017

1 reference

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Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08).

23 August 2017

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Power failure: why small sample size undermines the reliability of neuroscience

23 August 2017

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Translational predictive biomarker analysis of the phase 1b sorafenib and bevacizumab study expansion cohort.

23 August 2017

1 reference

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Randomized phase II trial designs with biomarkers

23 August 2017

1 reference

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Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development

23 August 2017

1 reference

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Diagnosing the decline in pharmaceutical R&D efficiency

23 August 2017

1 reference

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How chemoproteomics can enable drug discovery and development

23 August 2017

1 reference

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Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma

23 August 2017

1 reference

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Reengineering translational science: the time is right

23 August 2017

1 reference

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Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux®and particle therapy]

23 August 2017

1 reference

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Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification algorithms

23 August 2017

1 reference

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Cancer biomarkers: can we turn recent failures into success?

23 August 2017

1 reference

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Proteomic strategies in the search of new biomarkers in atherothrombosis

23 August 2017

1 reference

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The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee

23 August 2017

1 reference

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

23 August 2017

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Metabolomics applied to diabetes research: moving from information to knowledge

23 August 2017

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Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges.

23 August 2017

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Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash

23 August 2017

1 reference

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Activity-based probes as a tool for functional proteomic analysis of proteases.

23 August 2017

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Electrospray ionisation mass spectrometry: principles and clinical applications

23 August 2017

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Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening.

23 August 2017

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Protein microarray technology

23 August 2017

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Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?

23 August 2017

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Blood-brain barrier genomics, proteomics, and new transporter discovery

23 August 2017

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

23 August 2017

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Ribosome display: cell-free protein display technology

23 August 2017

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A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

23 August 2017

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The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysis

23 August 2017

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Proteomics in drug discovery

23 August 2017

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Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

23 August 2017

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Immunoassay using antigen-enzyme conjugates.

23 August 2017

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Placebo response in studies of major depression: variable, substantial, and growing

23 August 2017

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Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

23 August 2017

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Large-scale analysis of the yeast proteome by multidimensional protein identification technology

23 August 2017

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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

23 August 2017

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23 August 2017

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From proteins to proteomes: large scale protein identification by two-dimensional electrophoresis and amino acid analysis

23 August 2017

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Progress with gene-product mapping of the Mollicutes: Mycoplasma genitalium.

23 August 2017

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Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G

23 August 2017

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Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose

23 August 2017

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Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

23 August 2017

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Electrospray ionization for mass spectrometry of large biomolecules

23 August 2017

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Protein mapping by combined isoelectric focusing and electrophoresis of mouse tissues. A novel approach to testing for induced point mutations in mammals

23 August 2017

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High resolution two-dimensional electrophoresis of proteins

23 August 2017

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Phase-0/microdosing studies using PET, AMS, and LC-MS/MS: a range of study methodologies and conduct considerations. Accelerating development of novel pharmaceuticals through safe testing in humans - a practical guide.

23 August 2017

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Target identification of covalently binding drugs by activity-based protein profiling (ABPP).

6 September 2017

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Emerging applications of metabolomics in drug discovery and precision medicine

6 September 2017

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Proteomics in mechanistic toxicology: history, concepts, achievements, caveats, and potential

6 September 2017

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Biomarker enrichment strategies: matching trial design to biomarker credentials

6 September 2017

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Serum proteomics in biomedical research: a systematic review

6 September 2017

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Application of genomics, proteomics and metabolomics in drug discovery, development and clinic.

6 September 2017

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The long journey of cancer biomarkers from the bench to the clinic

6 September 2017

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Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes

6 September 2017

1 reference

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The productivity crisis in pharmaceutical R&D.

6 September 2017

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Progress with proteome projects: why all proteins expressed by a genome should be identified and how to do it.

6 September 2017

1 reference

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Improving clinical trial efficiency by biomarker-guided patient selection

28 September 2017

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Phospholipid- and Ca2 -dependent protein kinase activity and protein phosphorylation patterns in the differentiation of human promyelocytic leukemia cell line HL-60.

23 June 2018

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Two-dimensional gel analysis of soluble proteins. Charaterization of guinea pig exocrine pancreatic proteins

23 June 2018

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A signature for immune response correlates with HCV treatment outcome in Caucasian subjects

23 June 2018

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The PCAST report on pharmaceutical innovation: implications for the FDA.

1 September 2018

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Randomized phase II study of ixabepilone or paclitaxel plus carboplatin in patients with non-small-cell lung cancer prospectively stratified by beta-3 tubulin status

1 September 2018

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A retrospective analysis of VeriStrat status on outcome of a randomized phase II trial of first-line therapy with gemcitabine, erlotinib, or the combination in elderly patients (age 70 years or older) with stage IIIB/IV non-small-cell lung cancer

1 September 2018

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A phase II study of bevacizumab and erlotinib as initial treatment for metastatic non-squamous, non-small cell lung cancer with serum proteomic evaluation.

1 September 2018

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Tipifarnib plus tamoxifen in tamoxifen-resistant metastatic breast cancer: a negative phase II and screening of potential therapeutic markers by proteomic analysis.

1 September 2018

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Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a phase I dose-escalation study.

1 September 2018

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Lessons from 60 years of pharmaceutical innovation

1 September 2018

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Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer

1 September 2018

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Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127.

1 September 2018

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Origin of the word 'protein'.

1 September 2018

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Electroblotting onto activated glass. High efficiency preparation of proteins from analytical sodium dodecyl sulfate-polyacrylamide gels for direct sequence analysis

1 September 2018

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Bakerian Lecture: Rays of Positive Electricity

1 September 2018

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Matrix-assisted ultraviolet laser desorption of non-volatile compounds

21 January 2018

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Functional and quantitative proteomics using SILAC

21 January 2018

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Cancer biomarkers detection using 3D microstructured protein chip: Implementation of customized multiplex immunoassay

21 January 2018

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Gas-liquid chromatographic study and estimation of several urinary aromatic acids

21 January 2018

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12 December 2020

Activity-based proteomics: identification of ABHD11 and ESD activities as potential biomarkers for human lung adenocarcinoma

1 reference

12 December 2020

Pharmacogenomics/pharmacoproteomics Europe

1 reference

12 December 2020

Mass spectrometry in lipid research

1 reference

12 December 2020

Rapid phosphorylation-dephosphorylation of specific proteins induced by phorbol ester in HL-60 cells. Further characterization of the phosphorylation of 17-kilodalton and 27-kilodalton proteins in myeloid leukemic cells and human monocytes

1 reference

12 December 2020

A prospective analysis of imatinib-induced c-kit modulation in ovarian cancer

1 reference

12 December 2020

Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS18020448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28218733 AND SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28218733 AND SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

28218733

1 reference