Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A. (Q37677161)

21 August 2017

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title

Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A. (English)

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21 August 2017

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3

Moussa B H Youdim

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21 August 2017

1

Silvia A Mandel

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21 August 2017

2

Tali Fishman-Jacob

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21 August 2017

publication date

1 December 2009

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Parkinsonism and Related Disorders

21 August 2017

published in

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21 August 2017

volume

15 Suppl 3

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21 August 2017

page(s)

S148-51

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Genetics of Parkinson disease: paradigm shifts and future prospects.

21 August 2017

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Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes

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Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease

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Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms

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The comparative proteomics of ubiquitination in mouse

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

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Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

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Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

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Gene and protein signatures in sporadic Parkinson's disease and a novel genetic model of PD.

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CHIP: a quality-control E3 ligase collaborating with molecular chaperones

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Applying transcriptomic and proteomic knowledge to Parkinson's disease drug discovery

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7 January 2021

A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A

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ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia

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Hepatic aldehyde dehydrogenases and lipid peroxidation

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Human class I alcohol dehydrogenases catalyze the interconversion of alcohols and aldehydes in the metabolism of dopamine

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7 January 2021

A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.

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Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast

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Identifiers

DOI

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21 August 2017

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