Dehydroepiandrosterone as a regulator of immune cell function (Q37671302)

21 August 2017

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title

Dehydroepiandrosterone as a regulator of immune cell function (English)

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21 August 2017

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Janet M Lord

3

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Wiebke Arlt

object named as

Wiebke Arlt

series ordinal

2

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author name string

Jon Hazeldine

series ordinal

1

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21 August 2017

publication date

12 January 2010

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The Journal of Steroid Biochemistry and Molecular Biology

21 August 2017

published in

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21 August 2017

volume

120

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21 August 2017

issue

2-3

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21 August 2017

page(s)

127-136

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Serum dehydroepiandrosterone sulfate concentrations across the life span of laboratory-housed rhesus monkeys

21 August 2017

cites work

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26 December 2023

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Low serum levels of dehydroepiandrosterone may cause deficient IL-2 production by lymphocytes in patients with systemic lupus erythematosus (SLE)

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Immune response to influenza vaccination of elderly people. A randomized double-blind placebo-controlled trial

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An open study of dehydroepiandrosterone in systemic lupus erythematosus

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Human innate immunosenescence: causes and consequences for immunity in old age.

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Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats

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26 December 2023

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Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3).

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26 December 2023

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Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging

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26 December 2023

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Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence

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26 December 2023

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Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men.

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Immune up-regulation and tumor apoptosis by androstene steroids

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26 December 2023

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Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The influence of sequential annual vaccination and of DHEA administration on the efficacy of the immune response to influenza vaccine in the elderly

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis

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26 December 2023

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Dehydroepiandrosterone Antagonizes the Suppressive Effects of Dexamethasone on Lymphocyte Proliferation*

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Androstenediol regulates systemic resistance against lethal infections in mice

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Androstenediol and dehydroepiandrosterone protect mice against lethal bacterial infections and lipopolysaccharide toxicity

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Contrasting effects of glucocorticoids on the capacity of T cells to produce the growth factors interleukin 2 and interleukin 4.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus erythematosus.

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26 December 2023

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Dehydroepiandrosterone Treatment Is Not Beneficial to the Immune Response to Influenza in Elderly Subjects*

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The effect of DHEAS on influenza vaccination in aging adults

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone in systemic lupus erythematosus

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-gamma production in vitro

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

24-Hour Secretory Pattern of Dehydroisoandrosterone and Dehydroisoandrosterone Sulfate

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone sulfate enhances natural killer cell cytotoxicity in humans via locally generated immunoreactive insulin-like growth factor I

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Regulation of murine interleukin-10 production by dehydroepiandrosterone

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Infection in hospitalized trauma patients: incidence, risk factors, and complications

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Aging Alters Zonation in the Adrenal Cortex of Men

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Stress responses and innate immunity: aging as a contributory factor

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Protection by dehydroepiandrosterone in mice infected with viral encephalitis

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone and androsterone levels in human plasma: effect of age and sex; day-to-day and diurnal variations

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

DHEA induces 11 -HSD2 by acting on CCAAT/enhancer-binding proteins

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The aging immune system: primer and prospectus

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Adrenal glands of mouse and rat do not synthesize androgens

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone protects mice inoculated with West Nile virus and exposed to cold stress

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Activation of Human Monocytes by LPS and DHEA

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 mice, using exogenous dehydroepiandrosterone

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Hormonal and pregnancy relationships to rheumatoid arthritis: convergent effects with immunologic and microvascular systems

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The effect of dehydroepiandrosterone on hemorrhage-induced suppression of cellular immune function

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Reversal of the immunosenescent phenotype by dehydroepiandrosterone: hormone treatment provides an adjuvant effect on the immunization of aged mice with recombinant hepatitis B surface antigen

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The biological actions of dehydroepiandrosterone involves multiple receptors

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Effects of dehydroepiandrosterone administration on disease activity in patients with rheumatoid arthritis.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Estradiol binding to cell surface raises cytosolic free calcium in T cells

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The expression of 11 beta-hydroxysteroid dehydrogenase type I by lymphocytes provides a novel means for intracrine regulation of glucocorticoid activities.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Differential effect of DHEA on mitogen-induced proliferation of T and B lymphocytes

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone inhibits the amplification of glucocorticoid action in adipose tissue

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunity

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Synergistic interaction between dehydroepiandrosterone and prednisolone in the inhibition of rat lymphocyte proliferation

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Involvement of steroids and cytochromes P(450) species in the triggering of immune defenses

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Factors affecting the use of influenza vaccine in the institutionalized elderly

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Challenges for vaccination in the elderly.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Evidence for adrenocortical adaptation to severe illness

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-mediated mechanisms

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Amelioration of murine antigen-induced arthritis by dehydroepiandrosterone (DHEA).

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Metabolism of dehydroepiandrosterone

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26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

DHEAS as an effective vaccine adjuvant in elderly humans. Proof-of-principle studies.

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

DEHYDROEPIANDROSTERONE RESTORES IMMUNE FUNCTION FOLLOWING TRAUMA-HAEMORRHAGE BY A DIRECT EFFECT ON T LYMPHOCYTES

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Senescent decline in serum dehydroepiandrosterone sulfate concentrations in a population of wild baboons

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Prominent sex steroid metabolism in human lymphocytes

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Expression of 11beta-hydroxysteroid dehydrogenase type 1 permits regulation of glucocorticoid bioavailability by human dendritic cells

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone and its 7-hydroxylated metabolites do not interfere with the transactivation and cellular trafficking of the glucocorticoid receptor

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Psychoneuroendocrine Influences on Immunocompetence and Neoplasia

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Estrogen: a novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Studies on nuclear binding of dehydroepiandrosterone in hepatocytes

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Influence of gonadal steroids on brain corticosteroid receptors: a minireview

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA).

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Dehydroepiandrosterone replacement in women with adrenal insufficiency

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

The actions of exogenous dehydroepiandrosterone in experimental animals and humans

1 reference

26 December 2023

https://opencitations.net/index/api/v1/references/10.1016/J.JSBMB.2009.12.016

Identifiers

DOI

10.1016/J.JSBMB.2009.12.016

1 reference

21 August 2017

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