In vitro pharmacodynamic models to determine the effect of antibacterial drugs (Q37660762)

21 August 2017

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title

In vitro pharmacodynamic models to determine the effect of antibacterial drugs (English)

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21 August 2017

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3

Hartmut Derendorf

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21 August 2017

Julia Gloede

1

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21 August 2017

Christian Scheerans

series ordinal

2

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21 August 2017

Charlotte Kloft

series ordinal

4

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21 August 2017

language of work or name

English

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publication date

21 December 2009

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Journal of Antimicrobial Chemotherapy

21 August 2017

published in

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21 August 2017

volume

65

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21 August 2017

issue

2

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21 August 2017

page(s)

186-201

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Kinetics of pharmacologic response

21 August 2017

cites work

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In vivo antibiotic synergism: contribution of animal models

21 January 2018

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The crisis of resistance: identifying drug exposures to suppress amplification of resistant mutant subpopulations

21 January 2018

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Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration.

21 January 2018

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Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update

21 January 2018

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Pharmacological indices in antibiotic therapy

21 January 2018

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The role of PK/PD parameters to avoid selection and increase of resistance: mutant prevention concentration

21 January 2018

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Historical review of in-vitro models

21 January 2018

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Developments in PK/PD: optimising efficacy and prevention of resistance. A critical review of PK/PD in in vitro models

21 January 2018

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In-vitro model for simultaneous simulation of the serum kinetics of two drugs with different half-lives.

21 January 2018

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A simple dilution analog computer for simulation of drug distribution processes.

21 January 2018

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Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives

21 January 2018

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Mechanism-based pharmacokinetic-pharmacodynamic modeling of antimicrobial drug effects

21 January 2018

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Pharmacokinetic/pharmacodynamic evaluation of anti-infective agents

21 January 2018

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How predictive is PK/PD for antibacterial agents?

21 January 2018

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Application of logistic growth model to pharmacodynamic analysis of in vitro bactericidal kinetics

21 January 2018

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Semimechanistic pharmacokinetic/pharmacodynamic model for assessment of activity of antibacterial agents from time-kill curve experiments

21 January 2018

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Novel pharmacokinetic-pharmacodynamic model for prediction of outcomes with an extended-release formulation of ciprofloxacin

21 January 2018

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Modeling of microbial population responses to time-periodic concentrations of antimicrobial agents

21 January 2018

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A new modeling approach to the effect of antimicrobial agents on heterogeneous microbial populations

21 January 2018

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A pharmacodynamic model for the activity of antibiotics against microorganisms under nonsaturable conditions.

21 January 2018

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Pharmacodynamic modeling of ciprofloxacin resistance in Staphylococcus aureus

21 January 2018

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Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus

21 January 2018

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Mechanism-based pharmacodynamic models of fluoroquinolone resistance in Staphylococcus aureus

21 January 2018

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The theory and relevance of continuous culture

21 January 2018

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New in vitro kinetic model for evaluating bactericidal efficacy of antibiotics

21 January 2018

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Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC

21 January 2018

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Mathematical corrections for bacterial loss in pharmacodynamic in vitro dilution models

21 January 2018

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Correction for bacterial loss in in vitro dilution models

21 January 2018

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Two compartment kinetic model with multiple artificial capillary units

21 January 2018

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Killing of Pseudomonas aeruginosa during continuous and intermittent infusion of ceftazidime in an in vitro pharmacokinetic model

21 January 2018

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New In Vitro Model to Study the Effect of Antibiotic Concentration and Rate of Elimination on Antibacterial Activity

21 January 2018

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Artifacts in dilution pharmacokinetic models caused by adherent bacteria

21 January 2018

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Evaluation of ceftriaxone and other antibiotics against Escherichia coli, Pseudomonas aeruginosa, and Streptococcus pneumoniae under in vitro conditions simulating those of serious infections

21 January 2018

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Pharmacodynamics of the antibacterial effect and emergence of resistance to tomopenem, formerly RO4908463/CS-023, in an in vitro pharmacokinetic model of Staphylococcus aureus infection

21 January 2018

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Activities of moxifloxacin against, and emergence of resistance in, Streptococcus pneumoniae and Pseudomonas aeruginosa in an in vitro pharmacokinetic model

21 January 2018

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Comparative activity of cefixime and cefaclor in an in vitro model simulating human pharmacokinetics.

21 January 2018

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Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic model

21 January 2018

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Activity of moxifloxacin against Bacteroides fragilis and Escherichia coli in an in vitro pharmacokinetic/pharmacodynamic model employing pure and mixed cultures

21 January 2018

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Evaluation of two in vitro pharmacodynamic simulation models: microfiltration versus centrifugation-filtration

21 January 2018

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Pharmacodynamic studies of amoxicillin against Streptococcus pneumoniae: comparison of a new pharmacokinetically enhanced formulation (2000 mg twice daily) with standard dosage regimens

21 January 2018

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A dynamic model for in-vitro evaluation of antimicrobial action by simulation of the pharmacokinetic profiles of antibiotics

21 January 2018

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In Vitro Model Simulating the Form of Exposure of Bacteria to Antimicrobial Drugs Encountered in Infection

21 January 2018

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An in vitro pharmacodynamic model to simulate antibiotic behavior of acute otitis media with effusion

21 January 2018

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Activity of imipenem in an in-vitro model simulating pharmacokinetic parameters in human blood

21 January 2018

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Assessment of effects of protein binding on daptomycin and vancomycin killing of Staphylococcus aureus by using an in vitro pharmacodynamic model

21 January 2018

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Determination of antibiotic effect in an in vitro pharmacodynamic model: comparison with an established animal model of infection

21 January 2018

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Efficacy of intermittent versus continuous administration of netilmicin in a two-compartment in vitro model

21 January 2018

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New approach for accurate simulation of human pharmacokinetics in an in vitro pharmacodynamic model: application to ciprofloxacin

21 January 2018

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Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance

21 January 2018

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In vivo verification of in vitro model of antibiotic treatment of device-related infection

21 January 2018

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Development of a tissue culture model for gonococcal invasion

21 January 2018

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In vitro and ex vivo activities of antimicrobial agents used in combination with clarithromycin, with or without amikacin, against Mycobacterium avium

21 January 2018

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In vivo pharmacodynamics of ceftobiprole against multiple bacterial pathogens in murine thigh and lung infection models

21 January 2018

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Development of an integrated semi-automated system for in vitro pharmacodynamic modelling

21 January 2018

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Influence of growth rate on susceptibility to antimicrobial agents: modification of the cell envelope and batch and continuous culture studies

21 January 2018

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Differences between in vitro and in vivo studies

21 January 2018

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Comparative pharmacodynamics of gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa

21 January 2018

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Optimization of meropenem minimum concentration/MIC ratio to suppress in vitro resistance of Pseudomonas aeruginosa

21 January 2018

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Selection of a moxifloxacin dose that suppresses drug resistance in Mycobacterium tuberculosis, by use of an in vitro pharmacodynamic infection model and mathematical modeling

21 January 2018

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In vitro infection model characterizing the effect of efflux pump inhibition on prevention of resistance to levofloxacin and ciprofloxacin in Streptococcus pneumoniae

21 January 2018

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Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis

21 January 2018

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Mechanism-based pharmacokinetic-pharmacodynamic models of in vitro fungistatic and fungicidal effects against Candida albicans

21 January 2018

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Investigation of the early killing of Staphylococcus aureus by daptomycin by using an in vitro pharmacodynamic model

21 January 2018

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Evaluation of two methods for overcoming the antibiotic carry-over effect

21 January 2018

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Effects of imipenem on Escherichia coli studied using bioluminescence, viable counting and microscopy.

21 January 2018

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Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water, using Salmonella as a model organism

21 January 2018

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Advantages and limitations of quantitative PCR (Q-PCR)-based approaches in microbial ecology.

21 January 2018

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A novel in vitro pharmacokinetic/pharmacodynamic model based on two-compartment open model used to simulate serum drug concentration-time profiles

21 January 2018

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Bactericidal activities of teicoplanin, vancomycin, and gentamicin alone and in combination against Staphylococcus aureus in an in vitro pharmacodynamic model of endocarditis

21 January 2018

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Mechanisms of biofilm resistance to antimicrobial agents

21 January 2018

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Antibiotic resistance of Pseudomonas aeruginosa colonizing a urinary catheter in vitro.

21 January 2018

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Method of evaluating effects of antibiotics on bacterial biofilm

21 January 2018

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Tobramycin resistance of Pseudomonas aeruginosa cells growing as a biofilm on urinary catheter material

21 January 2018

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In Vitro Models That Support Adhesion Specificity in Biofilms of Oral Bacteria

21 January 2018

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Animal and cell-culture models for the study of mycobacterial infections and treatment

21 January 2018

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An in vitro model of the urinary bladder

21 January 2018

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An in-vitro model simulating the hydrokinetic aspects of the treatment of bacterial cystitis.

21 January 2018

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Activities of trovafloxacin, gatifloxacin, clinafloxacin, sparfloxacin, levofloxacin, and ciprofloxacin against penicillin-resistant Streptococcus pneumoniae in an in vitro infection model

21 January 2018

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Artificial Dental Plaque Biofilm Model Systems

21 January 2018

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A mixed-culture chemostat system to predict the effect of anti-microbial agents on the oral flora: preliminary studies using chlorhexidine

21 January 2018

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Impact of tazobactam pharmacokinetics on the antimicrobial effect of piperacillin-tazobactam combinations

21 January 2018

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Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh [...]

21 January 2018

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In vitro activities of quinupristin-dalfopristin and cefepime, alone and in combination with various antimicrobials, against multidrug-resistant staphylococci and enterococci in an in vitro pharmacodynamic model

21 January 2018

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In vitro activities of daptomycin, arbekacin, vancomycin, and gentamicin alone and/or in combination against glycopeptide intermediate-resistant Staphylococcus aureus in an infection model

21 January 2018

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Quantitative assessment of combination antimicrobial therapy against multidrug-resistant Acinetobacter baumannii

21 January 2018

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Novel approach to characterization of combined pharmacodynamic effects of antimicrobial agents

21 January 2018

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Caspofungin in combination with amphotericin B against Candida parapsilosis

21 January 2018

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In vitro pharmacodynamics of rapid versus continuous infusion of amphotericin B deoxycholate against Candida species in the presence of human serum albumin

21 January 2018

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A new in-vitro kinetic model to study the pharmacodynamics of antifungal agents: inhibition of the fungicidal activity of amphotericin B against Candida albicans by voriconazole

21 January 2018

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Effect of aerobic and anaerobic environments on antistaphylococcal activities of five fluoroquinolones

21 January 2018

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Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infection

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/JAC/DKP434

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21 August 2017

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