Molecular mechanisms underlying the activation of eNOS. (Q37655580)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

review article

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title

Molecular mechanisms underlying the activation of eNOS (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Ingrid Fleming

series ordinal

1

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21 August 2017

publication date

13 December 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

volume

459

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

issue

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

793-806

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

Inhibition of GTP-dependent vesicle trafficking impairs internalization of plasmalemmal eNOS and cellular nitric oxide production

15 January 2020

cites work

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12 December 2020

Involvement of Ca2 /calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation

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12 December 2020

Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells

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12 December 2020

Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaque

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12 December 2020

Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress

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12 December 2020

Recent advances in arginine metabolism: roles and regulation of the arginases

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12 December 2020

AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633

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12 December 2020

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme

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12 December 2020

AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets

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12 December 2020

Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme.

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12 December 2020

The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide

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12 December 2020

PECAM-1 interacts with nitric oxide synthase in human endothelial cells: implication for flow-induced nitric oxide synthase activation.

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12 December 2020

Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase

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12 December 2020

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

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12 December 2020

Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases

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12 December 2020

Endothelial cell-cell adhesion and mechanosignal transduction

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12 December 2020

Inactivation of SRC family tyrosine kinases by reactive oxygen species in vivo

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12 December 2020

Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation.

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12 December 2020

Homodimerization of soluble guanylyl cyclase subunits. Dimerization analysis using a glutathione s-transferase affinity tag.

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12 December 2020

Interaction of calmodulin-binding domain peptides of nitric oxide synthase with membrane phospholipids: regulation by protein phosphorylation and Ca(2 )-calmodulin

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12 December 2020

The key role of caveolin-1 in estrogen-mediated regulation of endothelial nitric oxide synthase function in cerebral arterioles in vivo

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12 December 2020

hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

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12 December 2020

Estrogen downregulates the number of caveolae and the level of caveolin in uterine smooth muscle

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12 December 2020

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

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12 December 2020

Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence

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12 December 2020

The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production

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12 December 2020

Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.

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12 December 2020

Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

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12 December 2020

Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production

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12 December 2020

Phosphorylation of endothelial nitric oxide synthase by atypical PKC zeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro.

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12 December 2020

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase

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12 December 2020

Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products

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12 December 2020

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

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12 December 2020

Flow-dependent regulation of endothelial Toll-like receptor 2 expression through inhibition of SP1 activity

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12 December 2020

Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters

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12 December 2020

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

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12 December 2020

Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway

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12 December 2020

Intracellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells

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12 December 2020

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

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12 December 2020

Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83.

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12 December 2020

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

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12 December 2020

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?

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12 December 2020

Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.

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12 December 2020

Hsp90 is regulated by a switch point in the C-terminal domain

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12 December 2020

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase

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12 December 2020

Activation and signaling by the AMP-activated protein kinase in endothelial cells

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12 December 2020

Endothelial dysfunction in heart failure.

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12 December 2020

Atherosclerosis and oxidant stress: the end of the road for antioxidant vitamin treatment?

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12 December 2020

Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells

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12 December 2020

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

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12 December 2020

Regulation of endothelial cell function BY FAK and PYK2.

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12 December 2020

Cerivastatin prevents tumor necrosis factor-alpha-induced downregulation of endothelial nitric oxide synthase: role of endothelial cytosolic proteins

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12 December 2020

Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002

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12 December 2020

Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.

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12 December 2020

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

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12 December 2020

Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis

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12 December 2020

Phosphorylation of Thr(495) regulates Ca(2 )/calmodulin-dependent endothelial nitric oxide synthase activity.

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12 December 2020

Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells

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12 December 2020

In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation

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12 December 2020

Angiotensin II signaling pathways mediated by tyrosine kinases.

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12 December 2020

Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function

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12 December 2020

Endothelial nitric oxide synthase activity is linked to its presence at cell-cell contacts

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12 December 2020

Structural basis for endothelial nitric oxide synthase binding to calmodulin

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12 December 2020

Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy

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12 December 2020

Switched at birth: a new family for PECAM-1.

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12 December 2020

Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase

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12 December 2020

Ca 2 -Independent Activation of the Endothelial Nitric Oxide Synthase in Response to Tyrosine Phosphatase Inhibitors and Fluid Shear Stress

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12 December 2020

Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

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12 December 2020

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

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12 December 2020

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

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12 December 2020

Disruption of methylarginine metabolism impairs vascular homeostasis

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12 December 2020

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

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12 December 2020

Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation

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12 December 2020

Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase

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12 December 2020

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

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12 December 2020

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

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12 December 2020

Nonuniformity of Endothelial Constitutive Nitric Oxide Synthase Distribution in Cardiac Endothelium

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12 December 2020

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

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12 December 2020

The proline-rich domain of dynamin-2 is responsible for dynamin-dependent in vitro potentiation of endothelial nitric-oxide synthase activity via selective effects on reductase domain function

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12 December 2020

GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP.

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12 December 2020

The "Gab" in signal transduction.

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12 December 2020

Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism

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12 December 2020

Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

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12 December 2020

Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635.

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12 December 2020

Role of endothelial nitric oxide in bone marrow-derived progenitor cell mobilization

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12 December 2020

SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells

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12 December 2020

Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences

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12 December 2020

Evidence against tetrahydrobiopterin depletion of vascular tissue exposed to nitric oxide/superoxide or nitroglycerin

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12 December 2020

Protein tyrosine kinase PYK2 involved in Ca(2 )-induced regulation of ion channel and MAP kinase functions

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12 December 2020

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production

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12 December 2020

Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase

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12 December 2020

Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes

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12 December 2020

AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function

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12 December 2020

Reciprocal regulation of endothelial nitric-oxide synthase by Ca2 -calmodulin and caveolin

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12 December 2020

eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues.

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12 December 2020

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases

1 reference

12 December 2020

Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress

1 reference

12 December 2020

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

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12 December 2020

Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress

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12 December 2020

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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12 December 2020

PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress

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12 December 2020

Temporal effects of 17beta-estradiol on caveolin-1 mRNA and protein in bovine aortic endothelial cells

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12 December 2020

Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells

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12 December 2020

Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension

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12 December 2020

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

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12 December 2020

Tyrosine phosphorylation of NOS3 in a breast cancer cell line and Src-transformed cells.

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12 December 2020

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease

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12 December 2020

Regulation of tetrahydrobiopterin biosynthesis by shear stress

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12 December 2020

Nitric-oxide-dependent pial arteriolar dilation in the female rat: effects of chronic estrogen depletion and repletion

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12 December 2020

Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83.

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12 December 2020

Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway

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12 December 2020

Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin

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12 December 2020

Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation

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12 December 2020

Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction.

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12 December 2020

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

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12 December 2020

Cigarette smoke-induced alterations in endothelial nitric oxide synthase phosphorylation: role of protein kinase C.

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12 December 2020

Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase

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12 December 2020

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

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12 December 2020

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

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12 December 2020

10.1007/S00424-009-0767-7

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20012875 AND SRC:MED&resulttype=core&format=json

15 January 2020

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