Clinical Potential of Neurosteroids for CNS Disorders. (Q37643528)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

review article

1 reference

title

Clinical Potential of Neurosteroids for CNS Disorders (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

author name string

William A Estes

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

publication date

5 May 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

number of pages

19

1 reference

Trends in Pharmacological Sciences

inferred from page(s)

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

volume

37

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

page(s)

543-561

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.

4 April 2020

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Estrous cycle regulation of extrasynaptic δ-containing GABA(A) receptor-mediated tonic inhibition and limbic epileptogenesis

23 August 2017

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Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy

23 August 2017

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Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

23 August 2017

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A mouse kindling model of perimenstrual catamenial epilepsy

23 August 2017

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Validation of the rat model of cryptogenic infantile spasms.

23 August 2017

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23 August 2017

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Neurosteroids: endogenous role in the human brain and therapeutic potentials

23 August 2017

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Disease-modifying activity of progesterone in the hippocampus kindling model of epileptogenesis

23 August 2017

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Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Delta subunit susceptibility variants E177A and R220H associated with complex epilepsy alter channel gating and surface expression of alpha4beta2delta GABAA receptors

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Catamenial epilepsy: Update on prevalence, pathophysiology and treatment from the findings of the NIH Progesterone Treatment Trial

23 August 2017

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6 September 2017

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6 September 2017

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The pathophysiological and pharmacological basis of current drug treatment of migraine headache

6 September 2017

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Neurosteroids as regenerative agents in the brain: therapeutic implications

6 September 2017

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6 September 2017

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The sticky issue of neurosteroids and GABA(A) receptors

6 September 2017

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Conserved site for neurosteroid modulation of GABA A receptors

14 September 2017

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Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice

14 September 2017

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Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns.

14 September 2017

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Anaesthesia and carbohydrate metabolism

14 September 2017

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Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics

14 September 2017

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Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship

28 September 2017

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Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one

28 September 2017

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Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy

28 September 2017

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Ganaxolone: a novel positive allosteric modulator of the GABA(A) receptor complex for the treatment of epilepsy

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Analgesic effects of intrathecally-administered 3 alpha-hydroxy-5 alpha-pregnan-20-one in a rat mechanical visceral pain model

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

A potential effect of ganaxolone in an animal model of infantile spasms.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Does vigabatrin treatment for infantile spasms cause visual field defects? An international multicentre study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Traumatic brain injury, posttraumatic stress disorder, and pain diagnoses in OIF/OEF/OND Veterans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Dual mechanisms diminishing tonic GABAA inhibition of dentate gyrus granule cells in Noda epileptic rats.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Anxiolytic activity of progesterone in progesterone receptor knockout mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Protective efficacy of neuroactive steroids against cocaine kindled-seizures in mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Reduced inhibition and sensitivity to neurosteroids in hippocampus of mice lacking the GABA(A) receptor delta subunit

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Ganaxolone for treating intractable infantile spasms: a multicenter, open-label, add-on trial

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Effect of ganaxolone on flurothyl seizures in developing rats

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Sensitization of gamma-aminobutyric acidA receptors to neuroactive steroids in rats during ethanol withdrawal.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5310676

ON THE HORMONAL ACTIVITY OF A STEROID COMPOUND

1 September 2018

1 reference

12 December 2020

Premenstrual changes: patterns and correlates of daily ratings

1 reference

12 December 2020

Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP)

1 reference

12 December 2020

ADDITIONAL STEROIDS WITH LUTEOID ACTIVITY

1 reference

12 December 2020

Modulation of the decrease in the seizure threshold of pentylenetetrazole in diazepam withdrawn mice by the neurosteroid 5αpregnan-3α,21-diol-20-one (alloTHDOC)

1 reference

12 December 2020

A Prospective Evaluation of the Effects of a 12-Week Outpatient Exercise Program on Clinical and Behavioral Outcomes in Patients with Epilepsy

1 reference

12 December 2020

Development and persistence of limbic epileptogenesis are impaired in mice lacking progesterone receptors

1 reference

12 December 2020

10.1016/J.TIPS.2016.04.003

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27156439 AND SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

27156439

1 reference