In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. (Q37637750)

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scientific article published on March 2014

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English	In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.	scientific article published on March 2014

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scholarly article

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Europe PubMed Central

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5 March 2020

In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects (English)

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Europe PubMed Central

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5 March 2020

triacylglycerol lipase inhibitor

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based on heuristic

inferred from title

Bogna M Ignatowska-Jankowska

1

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5 March 2020

8

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5 March 2020

10

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5 March 2020

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S Ghosh

2

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5 March 2020

M S Crowe

3

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5 March 2020

S G Kinsey

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5 March 2020

M J Niphakis

5

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5 March 2020

R A Abdullah

6

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5 March 2020

Q Tao

7

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5 March 2020

D M Walentiny

9

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B F Cravatt

11

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5 March 2020

A H Lichtman

12

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1 March 2014

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5 March 2020

British Journal of Pharmacology

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5 March 2020

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5 March 2020

6

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5 March 2020

1392-1407

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5 March 2020

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23 August 2017

Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects

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Novel 3-substituted rimonabant analogues lack Δ(9) -tetrahydrocannabinol-like abuse-related behavioural effects in mice

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Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics follo

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23 August 2017

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

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23 August 2017

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

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Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

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Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice

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23 August 2017

Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice

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23 August 2017

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

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23 August 2017

The fatty acid amide hydrolase (FAAH) inhibitor PF‐3845 acts in the nervous system to reverse LPS‐induced tactile allodynia in mice

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Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

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23 August 2017

Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain

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Endocannabinoid Overload: Fig. 1

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Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

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23 August 2017

Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

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Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

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Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase

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23 August 2017

FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration

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FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels

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Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

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23 August 2017

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism

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23 August 2017

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

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23 August 2017

Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception

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Phytochemical and genetic analyses of ancient cannabis from Central Asia

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N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase

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The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

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23 August 2017

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

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6 September 2017

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

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6 September 2017

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Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat.

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1 September 2018

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1 September 2018

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12 December 2020

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5 March 2020

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5 March 2020

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