Clostridial toxins (Q37613674)

21 August 2017

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title

Clostridial toxins (English)

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21 August 2017

Michel R Popoff

1

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21 August 2017

Philippe Bouvet

series ordinal

2

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21 August 2017

publication date

1 October 2009

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21 August 2017

number of pages

44

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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21 August 2017

volume

4

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21 August 2017

issue

8

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21 August 2017

page(s)

1021-1064

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The genome sequence of Clostridium tetani, the causative agent of tetanus disease

21 August 2017

cites work

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Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes

21 January 2018

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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

21 January 2018

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Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater

21 January 2018

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Bacterial protein toxins and lipids: pore formation or toxin entry into cells

21 January 2018

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Genetic characterization of type A enterotoxigenic Clostridium perfringens strains

21 January 2018

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Rapid expansion of the physical and genetic map of the chromosome of Clostridium perfringens CPN50.

21 January 2018

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Molecular features of the cytolytic pore-forming bacterial protein toxins

21 January 2018

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Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins

21 January 2018

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Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form

21 January 2018

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Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions

21 January 2018

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Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin

21 January 2018

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Contribution of individual tryptophan residues to the structure and activity of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin.

21 January 2018

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Selective binding of perfringolysin O derivative to cholesterol-rich membrane microdomains (rafts).

21 January 2018

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Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy

21 January 2018

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Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment.

21 January 2018

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Conformational changes that effect oligomerization and initiate pore formation are triggered throughout perfringolysin O upon binding to cholesterol.

21 January 2018

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Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

21 January 2018

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Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes

21 January 2018

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Beta-barrel pore-forming toxins: intriguing dimorphic proteins

21 January 2018

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The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

21 January 2018

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Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin

21 January 2018

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Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane

21 January 2018

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How interaction of perfringolysin O with membranes is controlled by sterol structure, lipid structure, and physiological low pH: insights into the origin of perfringolysin O-lipid raft interaction

21 January 2018

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Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene

21 January 2018

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Epsilon-toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model

21 January 2018

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The early effects of Clostridium perfringens type D epsilon toxin in ligated intestinal loops of goats and sheep

21 January 2018

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Clostridium perfringens epsilon toxin is absorbed from different intestinal segments of mice

21 January 2018

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Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

21 January 2018

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Diagnosis of Clostridium perfringens intestinal infections in sheep and goats

21 January 2018

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Neurological disorders produced by Clostridium perfringens type D epsilon toxin

21 January 2018

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Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells.

21 January 2018

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Binding of epsilon-toxin from Clostridium perfringens in the nervous system

21 January 2018

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Pathogenesis of brain damage produced in sheep by Clostridium perfringens type D epsilon toxin: a review

21 January 2018

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Lambda‐Toxin of Clostridium perfringens Activates the Precursor of Epsilon‐Toxin by Releasing Its N‐ and C‐Terminal Peptides

21 January 2018

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ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death.

21 January 2018

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Examination of toxicity of Clostridium perfringens -toxin in the MDCK cell line

21 January 2018

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Clostridium perfringens epsilon-toxin acts on MDCK cells by forming a large membrane complex

21 January 2018

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An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells

21 January 2018

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Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

21 January 2018

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Clostridium perfringens epsilon-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomes

21 January 2018

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Pore-forming epsilon toxin causes membrane permeabilization and rapid ATP depletion-mediated cell death in renal collecting duct cells.

21 January 2018

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Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells.

21 January 2018

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Oligomerization of Clostridium perfringens epsilon-toxin is dependent upon membrane fluidity in liposomes

21 January 2018

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Clostridium perfringens epsilon toxin induces a rapid change of cell membrane permeability to ions and forms channels in artificial lipid bilayers

21 January 2018

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Clostridium perfringens epsilon toxin rapidly decreases membrane barrier permeability of polarized MDCK cells

21 January 2018

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The Use of An Immunoperoxidase Technique to Investigate by Light and Electron Microscopy the Sites of Binding of Clostridium Welchii Type-D Epsilon Toxin in Mice

21 January 2018

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Neuronal damage produced in rat brains by Clostridium perfringens type D epsilon toxin

21 January 2018

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Clostridium perfringens prototoxin-induced alteration of endothelial barrier antigen (EBA) immunoreactivity at the blood-brain barrier (BBB).

21 January 2018

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The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin

21 January 2018

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Identification of functional domains of Clostridium septicum alpha toxin

21 January 2018

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Genetic variation and cross-reactivity of Clostridium septicum alpha-toxin

21 January 2018

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Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.

21 January 2018

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Requirement of N-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum alpha-toxin.

21 January 2018

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Cytotoxicity of Clostridium septicum alpha-toxin: its oligomerization in detergent resistant membranes of mammalian cells.

21 January 2018

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The propeptide of Clostridium septicum alpha toxin functions as an intramolecular chaperone and is a potent inhibitor of alpha toxin‐dependent cytolysis

21 January 2018

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Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin.

21 January 2018

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Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis

21 January 2018

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Pore-forming activity of alpha-toxin is essential for clostridium septicum-mediated myonecrosis.

21 January 2018

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Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum

21 January 2018

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Clostridium septicum alpha-toxin is active against the parasitic protozoan Toxoplasma gondii and targets members of the SAG family of glycosylphosphatidylinositol-anchored surface proteins.

21 January 2018

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Clostridium perfringens type A enterotoxin (CPE): more than just explosive diarrhea

21 January 2018

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Enterotoxin plasmid from Clostridium perfringens is conjugative.

21 January 2018

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The Clostridium perfringens enterotoxin gene is on a transposable element in type A human food poisoning strains

21 January 2018

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Genotyping of enterotoxigenic Clostridium perfringens fecal isolates associated with antibiotic-associated diarrhea and food poisoning in North America

21 January 2018

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Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates

21 January 2018

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Further comparison of temperature effects on growth and survival of Clostridium perfringens type A isolates carrying a chromosomal or plasmid-borne enterotoxin gene

21 January 2018

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Comparative effects of osmotic, sodium nitrite-induced, and pH-induced stress on growth and survival of Clostridium perfringens type A isolates carrying chromosomal or plasmid-borne enterotoxin genes

21 January 2018

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Clostridium perfringens type A strains carrying a plasmid-borne enterotoxin gene (genotype IS1151-cpe or IS1470-like-cpe) as a common cause of food poisoning

21 January 2018

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PCR identification of the plasmid-borne enterotoxin gene (cpe) in Clostridium perfringens strains isolated from food poisoning outbreaks.

21 January 2018

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Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein

21 January 2018

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Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin

21 January 2018

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Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.

21 January 2018

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Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3.

21 January 2018

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Structure of the claudin-binding domain of Clostridium perfringens enterotoxin

21 January 2018

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Evidence that membrane rafts are not required for the action of Clostridium perfringens enterotoxin

21 January 2018

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CaCo-2 cells treated with Clostridium perfringens enterotoxin form multiple large complex species, one of which contains the tight junction protein occludin

21 January 2018

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Identification of a prepore large-complex stage in the mechanism of action of Clostridium perfringens enterotoxin

21 January 2018

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Comparative biochemical and immunocytochemical studies reveal differences in the effects of Clostridium perfringens enterotoxin on polarized CaCo-2 cells versus Vero cells

21 January 2018

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An overview of Clostridium perfringens enterotoxin

21 January 2018

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Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity

21 January 2018

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Clostridium perfringens enterotoxin damages the human intestine in vitro

21 January 2018

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Both epsilon-toxin and beta-toxin are important for the lethal properties of Clostridium perfringens type B isolates in the mouse intravenous injection model

21 January 2018

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Dissecting the contributions of Clostridium perfringens type C toxins to lethality in the mouse intravenous injection model

21 January 2018

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Effects of Clostridium perfringens beta-toxin on the rabbit small intestine and colon

21 January 2018

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Clostridium perfringens beta-toxin forms potential-dependent, cation-selective channels in lipid bilayers

21 January 2018

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Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells

21 January 2018

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Involvement of tachykinin receptors in Clostridium perfringens beta-toxin-induced plasma extravasation

21 January 2018

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Involvement of tumour necrosis factor-alpha in Clostridium perfringens beta-toxin-induced plasma extravasation in mice

21 January 2018

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Beta2 toxin, a novel toxin produced by Clostridium perfringens

21 January 2018

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Antibiotic-induced expression of a cryptic cpb2 gene in equine beta2-toxigenic Clostridium perfringens

21 January 2018

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Regulated expression of the beta2-toxin gene (cpb2) in Clostridium perfringens type a isolates from horses with gastrointestinal diseases

21 January 2018

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Immunohistochemical localization of Clostridium perfringens beta2-toxin in the gastrointestinal tract of horses.

21 January 2018

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Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene

21 January 2018

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Association of beta2 toxin production with Clostridium perfringens type A human gastrointestinal disease isolates carrying a plasmid enterotoxin gene

21 January 2018

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Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets

21 January 2018

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NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens

21 January 2018

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Clostridium perfringens delta toxin is sequence related to beta toxin, NetB, and Staphylococcus pore-forming toxins, but shows functional differences

21 January 2018

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Multilocus sequence typing analysis of Clostridium perfringens isolates from necrotic enteritis outbreaks in broiler chicken populations

21 January 2018

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Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens.

21 January 2018

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Damaging effects of Clostridium perfringens delta toxin on blood platelets and their relevance to ganglioside GM2.

21 January 2018

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Interaction of Clostridium perfringens delta toxin with erythrocyte and liposome membranes and relation with the specific binding to the ganglioside GM2.

21 January 2018

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Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene

21 January 2018

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The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties

21 January 2018

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Sequence variation in the alpha-toxin encoding plc gene of Clostridium perfringens strains isolated from diseased and healthy chickens

21 January 2018

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Highly conserved alpha-toxin sequences of avian isolates of Clostridium perfringens

21 January 2018

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Structure of the key toxin in gas gangrene

21 January 2018

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Site-directed mutagenesis of histidine residues in Clostridium perfringens alpha-toxin

21 January 2018

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Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region

21 January 2018

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Role of the C-domain in the biological activities of Clostridium perfringens alpha-toxin

21 January 2018

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The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition.

21 January 2018

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A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene

21 January 2018

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Membrane-damaging action of Clostridium perfringens alpha-toxin on phospholipid liposomes

21 January 2018

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Effect of unsaturated bonds in the sn-2 acyl chain of phosphatidylcholine on the membrane-damaging action of Clostridium perfringens alpha-toxin toward liposomes

21 January 2018

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The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens alpha-toxin

21 January 2018

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Clostridium perfringens alpha-toxin: characterization and mode of action

21 January 2018

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Signal transduction mechanism involved in Clostridium perfringens alpha-toxin-induced superoxide anion generation in rabbit neutrophils

21 January 2018

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Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues

21 January 2018

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Activation of platelet gpIIbIIIa by phospholipase C from Clostridium perfringens involves store-operated calcium entry

21 January 2018

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Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens

21 January 2018

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Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells

21 January 2018

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Type-III effectors: sophisticated bacterial virulence factors

21 January 2018

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UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C.

21 January 2018

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Clostridial hydrolytic enzymes degrading extracellular components

21 January 2018

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A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation

21 January 2018

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Purification and characterization of Clostridium perfringens 120-kilodalton collagenase and nucleotide sequence of the corresponding gene

21 January 2018

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Construction and virulence testing of a collagenase mutant of Clostridium perfringens

21 January 2018

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Characterization of genes regulated directly by the VirR/VirS system in Clostridium perfringens

21 January 2018

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Clostridium perfringens: toxinotype and genotype

21 January 2018

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Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins

21 January 2018

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Bacterial toxins and virulence factors targeting the actin cytoskeleton and intercellular junctions

21 January 2018

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Clostridium perfringens iota-toxin requires activation of both binding and enzymatic components for cytopathic activity

21 January 2018

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Crystal structure of the anthrax toxin protective antigen

21 January 2018

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Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen

21 January 2018

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Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

21 January 2018

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The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen

21 January 2018

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Stoichiometry of anthrax toxin complexes

21 January 2018

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The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding

21 January 2018

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Clostridium perfringens iota-toxin: mapping of receptor binding and Ia docking domains on Ib.

21 January 2018

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Clostridium perfringens iota toxin: binding studies and characterization of cell surface receptor by fluorescence-activated cytometry

21 January 2018

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Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

21 January 2018

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Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex

21 January 2018

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Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin

21 January 2018

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Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization.

21 January 2018

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The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components

21 January 2018

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Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens -toxin

21 January 2018

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Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

21 January 2018

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Interaction of Clostridium perfringens iota-toxin with lipid bilayer membranes. Demonstration of channel formation by the activated binding component Ib and channel block by the enzyme component Ia.

21 January 2018

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Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient

21 January 2018

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Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex

21 January 2018

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Clostridium botulinum C2 toxin. Identification of the binding site for chloroquine and related compounds and influence of the binding site on properties of the C2II channel

21 January 2018

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Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin

21 January 2018

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The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

21 January 2018

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The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

21 January 2018

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The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex

21 January 2018

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Transcytosis of iota-toxin across polarized CaCo-2 cells

21 January 2018

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Disassembly of actin filaments by botulinum C2 toxin and actin-filament-disrupting agents induces assembly of microtubules in human leukaemia cell lines

21 January 2018

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C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins

21 January 2018

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Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis

21 January 2018

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Crystal structure of the Clostridium limosum C3 exoenzyme

21 January 2018

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C3 exoenzyme from Clostridium botulinum: structure of a tetragonal crystal form and a reassessment of NAD-induced flexure

21 January 2018

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The crystal structure of C3stau2 from Staphylococcus aureus and its complex with NAD

21 January 2018

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NAD binding induces conformational changes in Rho ADP-ribosylating clostridium botulinum C3 exoenzyme

21 January 2018

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Structural basis for the NAD-hydrolysis mechanism and the ARTT-loop plasticity of C3 exoenzymes

21 January 2018

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A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.

21 January 2018

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Rho GTPases and the Actin Cytoskeleton

21 January 2018

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Crystal structure of RhoA-GDP and its functional implications

21 January 2018

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Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.

21 January 2018

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Activation of phospholipase D1 by ADP-ribosylated RhoA

21 January 2018

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Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex

21 January 2018

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Inhibition of RhoA Translocation and Calcium Sensitization by In Vivo ADP-Ribosylation with the Chimeric Toxin DC3B

21 January 2018

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Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase

21 January 2018

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Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme

21 January 2018

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Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones

21 January 2018

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A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation

21 January 2018

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

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Rho-family GTPases in cadherin-mediated cell-cell adhesion

21 January 2018

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Rho-modifying C3-like ADP-ribosyltransferases

21 January 2018

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Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors

21 January 2018

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Prevalence of Rho-inactivating epidermal cell differentiation inhibitor toxins in clinical Staphylococcus aureus isolates

21 January 2018

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Characterization of the epidemic European fusidic acid-resistant impetigo clone of Staphylococcus aureus.

21 January 2018

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Structure and mode of action of clostridial glucosylating toxins: the ABCD model

21 January 2018

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A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C.

21 January 2018

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gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A.

21 January 2018

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Carbohydrate recognition by Clostridium difficile toxin A

21 January 2018

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Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A.

21 January 2018

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Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin

21 January 2018

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Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells

21 January 2018

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Conformational changes and reaction of clostridial glycosylating toxins

21 January 2018

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Structural basis for the function of Clostridium difficile toxin B.

21 January 2018

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Characterization of the catalytic domain of Clostridium novyi alpha-toxin

21 January 2018

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Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases

21 January 2018

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Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding

21 January 2018

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Change of the donor substrate specificity of Clostridium difficile toxin B by site-directed mutagenesis

21 January 2018

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A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity.

21 January 2018

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Impact of amino acids 22-27 of Rho-subfamily GTPases on glucosylation by the large clostridial cytotoxins TcsL-1522, TcdB-1470 and TcdB-8864.

21 January 2018

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Low pH-induced formation of ion channels by clostridium difficile toxin B in target cells

21 January 2018

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Clostridium difficile toxin A and its effects on cells

21 January 2018

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Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

21 January 2018

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pH-induced conformational changes in Clostridium difficile toxin B

21 January 2018

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pH-enhanced cytopathic effects of Clostridium sordellii lethal toxin

21 January 2018

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Cholesterol-dependent pore formation of Clostridium difficile toxin A.

21 January 2018

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Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate

21 January 2018

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Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity.

21 January 2018

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Autocatalytic cleavage of Clostridium difficile toxin B.

21 January 2018

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Glucosylation of Rho proteins by Clostridium difficile toxin B.

21 January 2018

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The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins

21 January 2018

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Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.

21 January 2018

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Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling

21 January 2018

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Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1.

21 January 2018

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Clostridium difficile toxins disrupt epithelial barrier function by altering membrane microdomain localization of tight junction proteins

21 January 2018

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Clostridium sordellii lethal toxin kills mice by inducing a major increase in lung vascular permeability

21 January 2018

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Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells

21 January 2018

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Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand

21 January 2018

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Clostridium difficile toxins: more than mere inhibitors of Rho proteins

21 January 2018

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Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria. Involvement of ATP-sensitive mitochondrial potassium channels.

21 January 2018

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Lethal toxin fromClostridium sordelliiinduces apoptotic cell death by disruption of mitochondrial homeostasis in HL-60 cells

21 January 2018

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Large clostridial cytotoxins

21 January 2018

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Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.

21 January 2018

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Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile

21 January 2018

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Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine.

21 January 2018

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p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis

21 January 2018

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Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes

21 January 2018

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Activation of a c-Jun-NH2-terminal kinase pathway by the lethal toxin from Clostridium sordellii, TcsL-82, occurs independently of the toxin intrinsic enzymatic activity and facilitates small GTPase glucosylation

21 January 2018

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Specific Inhibition of Phorbol Ester-stimulated Phospholipase D by Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B-1470 in HEK-293 Cells

21 January 2018

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Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA

21 January 2018

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RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1

21 January 2018

1 reference

Clostridium difficile--more difficult than ever

21 January 2018

1 reference

Clostridium difficile toxins: mechanism of action and role in disease

21 January 2018

1 reference

Toxin B is essential for virulence of Clostridium difficile

21 January 2018

1 reference

How botulinum and tetanus neurotoxins block neurotransmitter release.

21 January 2018

1 reference

Genetic diversity among Botulinum Neurotoxin-producing clostridial strains

21 January 2018

1 reference

Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids

21 January 2018

1 reference

Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization

21 January 2018

1 reference

A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4.

21 January 2018

1 reference

Sequencing the botulinum neurotoxin gene and related genes in Clostridium botulinum type E strains reveals orfx3 and a novel type E neurotoxin subtype

21 January 2018

1 reference

Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum

21 January 2018

1 reference

A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms

21 January 2018

1 reference

Subunit stoichiometry of the Clostridium botulinum type A neurotoxin complex determined using denaturing capillary electrophoresis

21 January 2018

1 reference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding

21 January 2018

1 reference

Sequence homology and structural analysis of the clostridial neurotoxins

21 January 2018

1 reference

Crystal structure of botulinum neurotoxin type A and implications for toxicity

21 January 2018

1 reference

Structure of the receptor binding fragment HC of tetanus neurotoxin

21 January 2018

1 reference

The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin

21 January 2018

1 reference

2.3 A crystal structure of tetanus neurotoxin light chain

21 January 2018

1 reference

Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

21 January 2018

1 reference

Crystal Structure of Botulinum Neurotoxin Type A in Complex with the Cell Surface Co-Receptor GT1b—Insight into the Toxin–Neuron Interaction

21 January 2018

1 reference

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation

21 January 2018

1 reference

Binding and transcytosis of botulinum neurotoxin by polarized human colon carcinoma cells

21 January 2018

1 reference

Structural features of the botulinum neurotoxin molecule that govern binding and transcytosis across polarized human intestinal epithelial cells

21 January 2018

1 reference

Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells

21 January 2018

1 reference

Disruption of the epithelial barrier by botulinum haemagglutinin (HA) proteins - differences in cell tropism and the mechanism of action between HA proteins of types A or B, and HA proteins of type C.

21 January 2018

1 reference

Tetanus and botulinum neurotoxins: turning bad guys into good by research

21 January 2018

1 reference

The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.

21 January 2018

1 reference

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

21 January 2018

1 reference

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

21 January 2018

1 reference

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

21 January 2018

1 reference

SV2 is the protein receptor for botulinum neurotoxin A.

21 January 2018

1 reference

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

21 January 2018

1 reference

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

21 January 2018

1 reference

Lipid rafts act as specialized domains for tetanus toxin binding and internalization into neurons

21 January 2018

1 reference

High sensitivity of mouse neuronal cells to tetanus toxin requires a GPI-anchored protein

21 January 2018

1 reference

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity

21 January 2018

1 reference

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

21 January 2018

1 reference

The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

21 January 2018

1 reference

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D.

21 January 2018

1 reference

Botulinum neurotoxin A changes conformation upon binding to ganglioside GT1b

21 January 2018

1 reference

Molecular basis for tetanus toxin coreceptor interactions

21 January 2018

1 reference

The journey of tetanus and botulinum neurotoxins in neurons

21 January 2018

1 reference

Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR.

21 January 2018

1 reference

Uptake and transport of Clostridium neurotoxins

21 January 2018

1 reference

Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1.

21 January 2018

1 reference

Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway

21 January 2018

1 reference

Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice

21 January 2018

1 reference

Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction.

21 January 2018

1 reference

Translocation of botulinum neurotoxin light chain protease through the heavy chain channel

21 January 2018

1 reference

Crucial role of the disulfide bridge between botulinum neurotoxin light and heavy chains in protease translocation across membranes

21 January 2018

1 reference

Translocation of botulinum neurotoxin light chain protease by the heavy chain protein-conducting channel

21 January 2018

1 reference

A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol

21 January 2018

1 reference

Ca(2 )-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion.

21 January 2018

1 reference

Reconstitution of Ca2 -regulated membrane fusion by synaptotagmin and SNAREs.

21 January 2018

1 reference

Distinct kinetic changes in neurotransmitter release after SNARE protein cleavage.

21 January 2018

1 reference

Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion

21 January 2018

1 reference

The C terminus of SNAP25 is essential for Ca(2 )-dependent binding of synaptotagmin to SNARE complexes

21 January 2018

1 reference

Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons

21 January 2018

1 reference

Rescue of exocytosis in botulinum toxin A-poisoned chromaffin cells by expression of cleavage-resistant SNAP-25. Identification of the minimal essential C-terminal residues.

21 January 2018

1 reference

Plasma membrane localization signals in the light chain of botulinum neurotoxin

21 January 2018

1 reference

A molecular basis underlying differences in the toxicity of botulinum serotypes A and E.

21 January 2018

1 reference

Botulinum toxin in clinical practice

21 January 2018

1 reference

Expanding use of botulinum toxin.

21 January 2018

1 reference

Botulinum toxin in urology: evaluation using an evidence-based medicine approach

21 January 2018

1 reference

Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals.

21 January 2018

1 reference

Subunit vaccine against the seven serotypes of botulism

21 January 2018

1 reference

Interaction between the two subdomains of the C-terminal part of the botulinum neurotoxin A is essential for the generation of protective antibodies.

21 January 2018

1 reference

Delivery of Recombinant Tetanus–Superoxide Dismutase Proteins to Central Nervous System Neurons by Retrograde Axonal Transport

21 January 2018

1 reference

Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4.

21 January 2018

1 reference

Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin.

21 January 2018

1 reference

Partial protection against Botulinum B neurotoxin-induced blocking of exocytosis by a potent inhibitor of its metallopeptidase activity

21 January 2018

1 reference

Synthesis of substrates and inhibitors of botulinum neurotoxin type A metalloprotease

21 January 2018

1 reference

Differential entry of botulinum neurotoxin A into neuronal and intestinal cells

21 January 2018

1 reference

Clostridium perfringens and foodborne infections

21 January 2018

1 reference

The enteric toxins of Clostridium perfringens

21 January 2018

1 reference

21 January 2018

1 reference

21 January 2018

Enterotoxaemia in goats

1 reference

Clostridial disease associated with neurologic signs: tetanus, botulism, and enterotoxemia

21 January 2018

1 reference

Clostridium perfringens type E enteritis in calves: two cases and a brief review of the literature

21 January 2018

1 reference

Nosocomial outbreak of Clostridium difficile-associated diarrhoea due to a clindamycin-resistant enterotoxin A-negative strain

21 January 2018

1 reference

Clostridium difficile: an important pathogen of food animals

21 January 2018

1 reference

Clostridium difficile infection in hospitals: a brewing storm

21 January 2018

1 reference

Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078.

21 January 2018

1 reference

Clostridial enteric infections in pigs

21 January 2018

1 reference

Clostridium difficile associated infection, diarrhea and colitis

21 January 2018

1 reference

Antibiotic-associated diarrhea: epidemiology, trends and treatment

21 January 2018

1 reference

Emergence of Clostridium difficile-associated disease in North America and Europe.

21 January 2018

1 reference

Clostridium septicum and malignancy

21 January 2018

1 reference

Clostridial disease of the gut.

21 January 2018

1 reference

Infant botulism: two recent cases and literature review

21 January 2018

1 reference

An overview of type E botulism in China

21 January 2018

1 reference

21 January 2018

1 reference

Food-borne botulism in the United Kingdom

21 January 2018

1 reference

Foodborne botulism in Italy

21 January 2018

1 reference

An outbreak of type C botulism in broiler chickens

21 January 2018

1 reference

Waterfowl toxicology: a review

21 January 2018

1 reference

Equine botulism and acute pasture myodystrophy: new soil-borne emerging diseases in Switzerland?

21 January 2018

1 reference

Avian botulism--another perspective

21 January 2018

1 reference

Fulminant liver failure following infection by Clostridium perfringens

21 January 2018

1 reference

Gas gangrene secondary to Clostridium perfringens in pediatric oncology patients.

21 January 2018

1 reference

Diagnosis and management of clostridium perfringens sepsis and uterine gas gangrene

21 January 2018

1 reference

Virulence genes of Clostridium perfringens.

21 January 2018

1 reference

Clostridium septicum infections in children: a case report and review of the literature

21 January 2018

1 reference

Clostridium septicum infection and hemolytic uremic syndrome

21 January 2018

1 reference

Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii

21 January 2018

1 reference

A fatal case of Clostridium sordellii septic shock syndrome associated with medical abortion

21 January 2018

1 reference

Toxic shock syndrome due to Clostridium sordellii: a dramatic postpartum and postabortion disease

21 January 2018

1 reference

The clinical spectrum of Clostridium sordellii bacteraemia: two case reports and a review of the literature

21 January 2018

1 reference

A fatal postpartum Clostridium sordellii associated toxic shock syndrome

21 January 2018

1 reference

Clostridium sordellii bacteremia: case report and review

21 January 2018

1 reference

Empyema caused by Clostridium sordellii, a rare form of pleuropulmonary disease

21 January 2018

1 reference

Maternal deaths associated with Clostridium sordellii infection

21 January 2018

1 reference

Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion

21 January 2018

1 reference

Tetanus in England and Wales, 1984-2000.

21 January 2018

1 reference

Epidemiology of tetanus in Denmark 1920-1982.

21 January 2018

1 reference

Epidemiology and immunity to tetanus in Sweden

21 January 2018

1 reference

Tetanus in developing countries: an update on the Maternal and Neonatal Tetanus Elimination Initiative

21 January 2018

1 reference

Tetanus in developing countries: a case series and review

21 January 2018

1 reference

Epidemiologic, clinical and laboratory aspects of wound botulism

21 January 2018

1 reference

Wound botulism in the UK and Ireland

21 January 2018

1 reference

Wound botulism in California, 1951-1998: recent epidemic in heroin injectors

21 January 2018

1 reference

Wound botulism in injection drug users

21 January 2018

1 reference

Cholesterol-binding cytolytic protein toxins

21 January 2018

1 reference

Clostridium perfringens ɛ-toxin

21 January 2018

1 reference

A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins

21 January 2018

1 reference

The α-toxin ofClostridium septicumis essential for virulence

21 January 2018

1 reference

Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model

21 January 2018

1 reference

The Clostridium perfringensα-toxin

21 January 2018

1 reference

Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation

21 January 2018

1 reference

Membrane-damaging and cytotoxic phospholipases

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.09.72

1 reference

21 August 2017

1 reference