Biological determinants of endocrine resistance in breast cancer (Q37585095)

21 August 2017

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title

Biological determinants of endocrine resistance in breast cancer (English)

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21 August 2017

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Elizabeth A Musgrove

1

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21 August 2017

Robert L Sutherland

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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21 August 2017

published in

Nature Reviews Cancer

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21 August 2017

volume

9

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21 August 2017

issue

9

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21 August 2017

page(s)

631-643

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Connections and regulation of the human estrogen receptor

21 August 2017

cites work

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Endocrine-responsive breast cancer and strategies for combating resistance

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CYP2D6 and tamoxifen: DNA matters in breast cancer

31 March 2020

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Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.

31 March 2020

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Selective estrogen receptor modulation: concept and consequences in cancer

31 March 2020

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Mechanisms of tamoxifen resistance

31 March 2020

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Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer

31 March 2020

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Growth factor signalling in endocrine and anti-growth factor resistant breast cancer.

31 March 2020

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Selective estrogen-receptor modulators and antihormonal resistance in breast cancer

31 March 2020

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Pathways to tamoxifen resistance

31 March 2020

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Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance

31 March 2020

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Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase

31 March 2020

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Estrogen receptor mutations in human disease

31 March 2020

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Expression of ER-{alpha}36, a novel variant of estrogen receptor {alpha}, and resistance to tamoxifen treatment in breast cancer

31 March 2020

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Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy

31 March 2020

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Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?

31 March 2020

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ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer

31 March 2020

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Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo

31 March 2020

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Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer

31 March 2020

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Novel mechanisms of resistance to endocrine therapy: genomic and nongenomic considerations

31 March 2020

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Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer

31 March 2020

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Regulation of estrogen rapid signaling through arginine methylation by PRMT1

31 March 2020

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Epidermal-growth-factor receptors and oestrogen receptors in human breast cancer

31 March 2020

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Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity

31 March 2020

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Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

31 March 2020

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Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer

31 March 2020

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Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex).

31 March 2020

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Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells

31 March 2020

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Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells.

31 March 2020

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A negative feedback regulatory loop associates the tyrosine kinase receptor ERBB2 and the transcription factor GATA4 in breast cancer cells

31 March 2020

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FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene

31 March 2020

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Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen

31 March 2020

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Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment.

31 March 2020

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Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.

31 March 2020

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Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells

31 March 2020

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Nuclear p21-activated kinase 1 in breast cancer packs off tamoxifen sensitivity.

31 March 2020

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Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer

31 March 2020

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Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells

31 March 2020

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c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry

31 March 2020

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C-myc gene expression alone is sufficient to confer resistance to antiestrogen in human breast cancer cells

31 March 2020

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Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest

31 March 2020

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Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

31 March 2020

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A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence

31 March 2020

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The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer

31 March 2020

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Functional ablation of pRb activates Cdk2 and causes antiestrogen resistance in human breast cancer cells

31 March 2020

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Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists

31 March 2020

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c-Myc suppresses p21WAF1/CIP1 expression during estrogen signaling and antiestrogen resistance in human breast cancer cells.

31 March 2020

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Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc

31 March 2020

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Linking cyclins to transcriptional control.

31 March 2020

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Tamoxifen stimulates the growth of cyclin D1-overexpressing breast cancer cells by promoting the activation of signal transducer and activator of transcription 3.

31 March 2020

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Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

31 March 2020

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Cell cycle control in breast cancer cells

31 March 2020

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

31 March 2020

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MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1

31 March 2020

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MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer

31 March 2020

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FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus

31 March 2020

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Mechanisms of tamoxifen-induced apoptosis

31 March 2020

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Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance

31 March 2020

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Live or let die: oestrogen regulation of survival signalling in endocrine response

31 March 2020

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The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells

31 March 2020

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Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

31 March 2020

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Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer

31 March 2020

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Gene-expression signatures in breast cancer

31 March 2020

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Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

31 March 2020

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Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer

31 March 2020

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Concordance among gene-expression-based predictors for breast cancer

31 March 2020

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Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade

31 March 2020

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Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen

31 March 2020

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Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

31 March 2020

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A modular analysis of breast cancer reveals a novel low-grade molecular signature in estrogen receptor-positive tumors.

31 March 2020

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Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response

31 March 2020

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Outcome signature genes in breast cancer: is there a unique set?

31 March 2020

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Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers

31 March 2020

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A transcriptional fingerprint of estrogen in human breast cancer predicts patient survival

31 March 2020

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Progesterone receptors as a prognostic factor in Stage II breast cancer

31 March 2020

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

31 March 2020

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Breast cancer classification and prognosis based on gene expression profiles from a population-based study

31 March 2020

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Repeated observation of breast tumor subtypes in independent gene expression data sets

31 March 2020

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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

31 March 2020

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Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer

31 March 2020

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Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics

31 March 2020

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Molecular concepts analysis links tumors, pathways, mechanisms, and drugs

31 March 2020

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Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

31 March 2020

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Linking oncogenic pathways with therapeutic opportunities

31 March 2020

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Functional identification of genes causing estrogen independence of human breast cancer cells

31 March 2020

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Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells

31 March 2020

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BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells

31 March 2020

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Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells

31 March 2020

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Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance

31 March 2020

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TSC22D1 and PSAP predict clinical outcome of tamoxifen treatment in patients with recurrent breast cancer

31 March 2020

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The prognostic value of BCAR1 in patients with primary breast cancer.

31 March 2020

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Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

31 March 2020

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Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

31 March 2020

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A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells

31 March 2020

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Deregulated cyclin D1 expression is associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines

31 March 2020

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Targeting c-Src kinase enhances tamoxifen's inhibitory effect on cell growth by modulating expression of cell cycle and survival proteins

31 March 2020

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Expression of a phosphorylated p130(Cas) substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells.

31 March 2020

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NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen

31 March 2020

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Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer

31 March 2020

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Clinical trials update: endocrine and biological therapy combinations in the treatment of breast cancer.

31 March 2020

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Modelling Myc inhibition as a cancer therapy

31 March 2020

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Cyclin-dependent kinase pathways as targets for cancer treatment

31 March 2020

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Controlling nuclear receptors: the circular logic of cofactor cycles

31 March 2020

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Estrogen receptor null mice: what have we learned and where will they lead us?

31 March 2020

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Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D.

31 March 2020

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Phospho-serine-118 estrogen receptor-alpha expression is associated with better disease outcome in women treated with tamoxifen

31 March 2020

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The NFkappaB pathway and endocrine-resistant breast cancer

31 March 2020

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Coassociation of estrogen receptor and p160 proteins predicts resistance to endocrine treatment; SRC-1 is an independent predictor of breast cancer recurrence

31 March 2020

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Estrogen receptor co-activator (AIB1) protein expression by automated quantitative analysis (AQUA) in a breast cancer tissue microarray and association with patient outcome

31 March 2020

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The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome

31 March 2020

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HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study

31 March 2020

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

31 March 2020

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Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer

31 March 2020

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Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen

31 March 2020

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AKT activation predicts outcome in breast cancer patients treated with tamoxifen

31 March 2020

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Activation of PI3K/Akt signaling and hormone resistance in breast cancer

31 March 2020

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Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen

31 March 2020

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Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome

31 March 2020

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Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer.

31 March 2020

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C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance

31 March 2020

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High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin

31 March 2020

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Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index

31 March 2020

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Bad expression predicts outcome in patients treated with tamoxifen.

31 March 2020

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A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

31 March 2020

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A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

31 March 2020

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Molecular classification of tamoxifen-resistant breast carcinomas by gene expression profiling

31 March 2020

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Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis

31 March 2020

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A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer

31 March 2020

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Estrogen regulated gene expression in response to neoadjuvant endocrine therapy of breast cancers: tamoxifen agonist effects dominate in the presence of an aromatase inhibitor

31 March 2020

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Molecular signatures of neoadjuvant endocrine therapy for breast cancer: characteristics of response or intrinsic resistance

31 March 2020

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Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

31 March 2020

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A candidate molecular signature associated with tamoxifen failure in primary breast cancer

31 March 2020

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Basic guide to the mechanisms of antiestrogen action

31 March 2020

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12 December 2020

Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays.

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12 December 2020

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

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12 December 2020

Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells

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12 December 2020

p27(Kip1) induces quiescence and growth factor insensitivity in tamoxifen-treated breast cancer cells

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12 December 2020

Modulation of the growth-inhibitory effects of progestins and the antiestrogen hydroxyclomiphene on human breast cancer cells by epidermal growth factor and insulin

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12 December 2020

Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer.

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12 December 2020

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

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12 December 2020

The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells

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12 December 2020

An expression signature of estrogen-regulated genes predicts disease-free survival in tamoxifen-treated patients better than progesterone receptor status.

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12 December 2020

Expression of constitutively active Akt-3 in MCF-7 breast cancer cells reverses the estrogen and tamoxifen responsivity of these cells in vivo.

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12 December 2020

Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistance

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12 December 2020

AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter

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12 December 2020

Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site

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12 December 2020

Expression of bcl-2 protein predicts efficacy of adjuvant treatments in operable node-positive breast cancer

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12 December 2020

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

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12 December 2020

The estrogen receptor: a model for molecular medicine.

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12 December 2020

Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.

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12 December 2020

Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780).

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12 December 2020

Identifiers

DOI

10.1038/NRC2713

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21 August 2017

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