Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension (Q37576723)

21 August 2017

Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension (English)

1 reference

21 August 2017

0 references

arterial hypertension

0 references

author

Hirofumi Sawada

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

1 June 2020

Jason P. Glotzbach

5

1 reference

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1 June 2020

Gabriele Fuchs

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

1 June 2020

18

Geoffrey C Gurtner

1 reference

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1 June 2020

author name string

Toshie Saito

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

1 June 2020

Nils P Nickel

3

1 reference

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1 June 2020

Tero-Pekka Alastalo

4

1 reference

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1 June 2020

Roshelle Chan

6

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1 June 2020

Leila Haghighat

7

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1 June 2020

Michael Januszyk

9

1 reference

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1 June 2020

Aiqin Cao

10

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1 June 2020

Ying-Ju Lai

11

1 reference

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1 June 2020

Vinicio de Jesus Perez

12

1 reference

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1 June 2020

Yu-Mee Kim

13

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1 June 2020

Lingli Wang

14

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1 June 2020

Pin-I Chen

15

1 reference

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1 June 2020

Edda Spiekerkoetter

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

1 June 2020

Yoshihide Mitani

17

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1 June 2020

Peter Sarnow

19

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1 June 2020

Marlene Rabinovitch

20

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1 June 2020

language of work or name

English

0 references

publication date

20 January 2014

1 reference

Journal of Experimental Medicine

21 August 2017

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1 June 2020

volume

211

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1 June 2020

issue

2

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1 June 2020

page(s)

263-280

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension

1 June 2020

cites work

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Circulating Myeloid-Derived Suppressor Cells Are Increased and Activated in Pulmonary Hypertension

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A novel role for hSMG-1 in stress granule formation

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Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

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Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

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Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha

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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

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Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

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An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension

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Stress granules: the Tao of RNA triage

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Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension

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HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques

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Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

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Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage

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Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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The RasGAP-associated endoribonuclease G3BP assembles stress granules

23 August 2017

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Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2

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6 September 2017

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14 September 2017

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14 September 2017

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Acute and long-term TNF-alpha administration increases pulmonary vascular reactivity in isolated rat lungs

28 September 2017

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Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension.

28 September 2017

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GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

25 June 2018

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Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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25 June 2018

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Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice.

1 September 2018

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Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension

1 September 2018

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Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice

1 September 2018

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1 September 2018

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1 September 2018

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1 September 2018

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1 September 2018

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

1 September 2018

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The implications of granulocyte-monocyte colony-stimulating factor (GM-CSF) in cytotoxicity of bone marrow transplantation.

1 September 2018

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Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension.

1 September 2018

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Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

1 September 2018

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Crossref

https://api.crossref.org/works/10.1084/JEM.20111741

Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate

21 January 2018

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Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle

21 January 2018

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12 December 2020

Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin

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12 December 2020

A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation

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12 December 2020

Locally applied GM-CSF induces the accumulation of alpha-smooth muscle actin containing myofibroblasts

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T lymphocytes affect smooth muscle cell phenotype and proliferation

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GM-CSF rapidly primes mice for enhanced cytokine production in response to LPS and TNF

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Cytokine regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) production by human retinal pigment epithelial cells

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Induction of human matrix metalloproteinase-12 gene transcriptional activity by GM-CSF requires the AP-1 binding site in human U937 monocytic cells

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Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression

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Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry

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Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation

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Identifiers

DOI

10.1084/JEM.20111741

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

24446489

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24446489 AND SRC:MED&resulttype=core&format=json