BAD: undertaker by night, candyman by day. (Q37566231)

21 August 2017

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title

BAD: undertaker by night, candyman by day. (English)

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21 August 2017

N N Danial

1

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21 August 2017

language of work or name

English

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publication date

1 December 2008

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21 August 2017

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21 August 2017

volume

27 Suppl 1

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21 August 2017

page(s)

S53-70

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The survival kinases Akt and Pim as potential pharmacological targets

21 August 2017

cites work

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Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

21 January 2018

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Glucokinase regulatory protein is associated with mitochondria in hepatocytes

21 January 2018

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Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis

21 January 2018

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A role for F-actin in hexokinase-mediated glucose signaling

21 January 2018

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A-kinase anchoring proteins take shape

21 January 2018

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Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids

21 January 2018

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

21 January 2018

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

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Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest

21 January 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Organelle-specific targeting of protein kinase AII (PKAII). Molecular and in situ characterization of murine A kinase anchor proteins that recruit regulatory subunits of PKAII to the cytoplasmic surface of mitochondria

21 January 2018

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Mitochondrial factors with dual roles in death and survival

21 January 2018

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

21 January 2018

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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

21 January 2018

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

21 January 2018

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Caspase cleavage enhances the apoptosis-inducing effects of BAD.

21 January 2018

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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

21 January 2018

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Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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Cell death: critical control points

21 January 2018

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

21 January 2018

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Cellular survival: a play in three Akts

21 January 2018

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

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14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

21 January 2018

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Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

21 January 2018

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cAMP-dependent protein kinase regulates the mitochondrial import of the nuclear encoded NDUFS4 subunit of complex I.

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

21 January 2018

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Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1.

21 January 2018

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

21 January 2018

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S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling

21 January 2018

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Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

21 January 2018

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Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

21 January 2018

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High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

21 January 2018

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

21 January 2018

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Tuberin activates the proapoptotic molecule BAD.

21 January 2018

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BAX activation is initiated at a novel interaction site

21 January 2018

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Cerebral preconditioning and ischaemic tolerance

21 January 2018

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Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells.

21 January 2018

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FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

21 January 2018

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Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor

21 January 2018

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Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?

21 January 2018

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Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

21 January 2018

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

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Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

21 January 2018

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

21 January 2018

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Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding

21 January 2018

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Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas.

21 January 2018

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Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission

21 January 2018

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Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets.

21 January 2018

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The ontogeny of insulin-like growth factor (IGF) and IGF-binding protein gene expression in the rat pancreas.

21 January 2018

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A RSK(y) relationship with promiscuous PKA.

21 January 2018

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Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits

21 January 2018

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Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line

21 January 2018

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Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

21 January 2018

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Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

21 January 2018

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Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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Proapoptotic BID is an ATM effector in the DNA-damage response

21 January 2018

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Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

21 January 2018

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Role of Bax and Bak in mitochondrial morphogenesis

21 January 2018

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Bcl-2-family proteins: the role of the BH3 domain in apoptosis

21 January 2018

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Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma

21 January 2018

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Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells

21 January 2018

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Pro-apoptotic PUMA and anti-apoptotic phospho-BAD are highly expressed in colorectal carcinomas

21 January 2018

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Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cells

21 January 2018

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Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery

21 January 2018

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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BH3-only proteins in cell death initiation, malignant disease and anticancer therapy.

21 January 2018

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

21 January 2018

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Inactivating mutations of proapoptotic Bad gene in human colon cancers

21 January 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

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Autophagy in the Pathogenesis of Disease

21 January 2018

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Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

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Autophagy in cell death: an innocent convict?

21 January 2018

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Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

21 January 2018

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Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival

21 January 2018

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The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

21 January 2018

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

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Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons

21 January 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.

21 January 2018

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Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism.

21 January 2018

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Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

21 January 2018

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Apoptosis, autophagy, and more

21 January 2018

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Growth factor regulation of autophagy and cell survival in the absence of apoptosis

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

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Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL

21 January 2018

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Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

21 January 2018

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Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila

21 January 2018

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Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer

21 January 2018

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Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

21 January 2018

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Bad can act as a key regulator of T cell apoptosis and T cell development.

21 January 2018

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Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy

21 January 2018

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Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling

21 January 2018

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Co-localization of glucokinase with actin filaments

21 January 2018

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Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia

21 January 2018

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Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice

21 January 2018

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Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

21 January 2018

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FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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Regulation of cell death: the calcium-apoptosis link

21 January 2018

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Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins

21 January 2018

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Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

21 January 2018

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Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.

21 January 2018

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

21 January 2018

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Bcl-2 and Ca2 homeostasis in the endoplasmic reticulum

21 January 2018

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Physiologic relevance of heterogeneity in the pancreatic beta-cell population

21 January 2018

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Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

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Autophagy in the eukaryotic cell

21 January 2018

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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

21 January 2018

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High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

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Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways

21 January 2018

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Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation

21 January 2018

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Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

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BAD is a pro-survival factor prior to activation of its pro-apoptotic function

21 January 2018

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

21 January 2018

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Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase:glucokinase complex

21 January 2018

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A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory

21 January 2018

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Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice

21 January 2018

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WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines

21 January 2018

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BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

21 January 2018

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PKA: a portrait of protein kinase dynamics

21 January 2018

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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

21 January 2018

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

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Growth factors can influence cell growth and survival through effects on glucose metabolism

21 January 2018

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Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

21 January 2018

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Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

21 January 2018

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Glycolytic enzyme interactions with yeast and skeletal muscle F-actin

21 January 2018

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A stapled BID BH3 helix directly binds and activates BAX

21 January 2018

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Ca2 -induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

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Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

21 January 2018

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

21 January 2018

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Minireview: implication of mitochondria in insulin secretion and action

21 January 2018

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Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

21 January 2018

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Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines

21 January 2018

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

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Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus

21 January 2018

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The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

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JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

21 January 2018

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BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity

21 January 2018

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

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Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155.

21 January 2018

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BCL2 family in DNA damage and cell cycle control

21 January 2018

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A role for proapoptotic BID in the DNA-damage response

21 January 2018

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-Cell Mitochondria Exhibit Membrane Potential Heterogeneity That Can Be Altered by Stimulatory or Toxic Fuel Levels

21 January 2018

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Essential role of A-kinase anchor protein 121 for cAMP signaling to mitochondria

21 January 2018

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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

31 March 2020

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The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

31 March 2020

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Differential effects of age versus glycemic stimulation on the maturation of insulin stimulus-secretion coupling during culture of fetal rat islets

31 March 2020

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The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

31 March 2020

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Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

31 March 2020

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Modulation of synaptic transmission by the BCL-2 family protein BCL-xL.

31 March 2020

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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

31 March 2020

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Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival

31 March 2020

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Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models

31 March 2020

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

31 March 2020

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Enhanced redundancy in Akt and mitogen-activated protein kinase-induced survival of malignant versus normal prostate epithelial cells

31 March 2020

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Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons

31 March 2020

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Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion

31 March 2020

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Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

14-3-3 inhibits Bad-induced cell death through interaction with serine-136

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2009.44

1 reference

21 August 2017

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