New insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition (Q37563033)

21 August 2017

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title

New insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition (English)

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21 August 2017

3

Michel Cusson

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21 August 2017

Sophie Vandermoten

1

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21 August 2017

Eric Haubruge

series ordinal

2

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21 August 2017

publication date

26 July 2009

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Cellular and Molecular Life Sciences

21 August 2017

published in

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21 August 2017

volume

66

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21 August 2017

issue

23

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21 August 2017

page(s)

3685-3695

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Human liver prenyltransferase and its characterization

21 August 2017

cites work

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Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity

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Developments in the therapeutic applications of bisphosphonates

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The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates

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A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis

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Structure of a functional geranylgeranyl pyrophosphate synthase gene from Capsicum annuum

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Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata

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Therapeutic approaches to bone diseases

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Functional identification of al-3 from Neurospora crassa as the gene for geranylgeranyl pyrophosphate synthase by complementation with crt genes, in vitro characterization of the gene product and mutant analysis

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Molecular cloning of geranyl diphosphate synthase and compartmentation of monoterpene synthesis in plant cells

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Cloning and characterization of two different types of geranyl diphosphate synthases from Norway spruce (Picea abies).

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Alteration of the product specificities of prenyltransferases by metal ions

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Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity.

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12 December 2020

A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.

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Cloning and characterisation of a prenyltransferase from the aphid Myzus persicae with potential involvement in alarm pheromone biosynthesis

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Purification and Characterization of Geranyl Diphosphate Synthase from Vitis vinifera L. cv Muscat de Frontignan Cell Cultures

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Identification of a short (C15) chain Z-isoprenyl diphosphate synthase and a homologous long (C50) chain isoprenyl diphosphate synthase in Mycobacterium tuberculosis

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Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase

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Geranyl diphosphate synthase from Abies grandis: cDNA isolation, functional expression, and characterization

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Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis

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Farnesyl diphosphate synthase. Altering the catalytic site to select for geranyl diphosphate activity

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12 December 2020

Modular networks and cumulative impact of lateral transfer in prokaryote genome evolution

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12 December 2020

Regulation of product chain length by isoprenyl diphosphate synthases

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12 December 2020

Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormones

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12 December 2020

Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis)

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An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase

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12 December 2020

Cloning, expression and characterization of a dipteran farnesyl diphosphate synthase

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12 December 2020

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

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12 December 2020

Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis

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12 December 2020

Purification and properties of pig liver prenyltransferase: interconvertible forms of the enzyme

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12 December 2020

Cloning and expression of a geranylgeranyl diphosphate synthase gene: insights into the synthesis of termite defence secretion

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12 December 2020

Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase fromSaccharomyces cerevisiaeand the Mechanism of Product Chain Length Determination

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12 December 2020

Mechanisms of action of bisphosphonates

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12 December 2020

Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate

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12 December 2020

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12 December 2020

Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II

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12 December 2020

Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis

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12 December 2020

Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution

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12 December 2020

Purification and characterization of farnesyl pyrophosphate synthase from Capsicum annuum

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12 December 2020

Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate

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12 December 2020

Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity.

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12 December 2020

Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution.

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12 December 2020

Molecular cloning and tissue expression of an insect farnesyl diphosphate synthase

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12 December 2020

Variable product specificity of solanesyl pyrophosphate synthetase

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12 December 2020

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

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12 December 2020

Protein design of geranyl diphosphate synthase. Structural features that define the product specificities of prenyltransferases

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12 December 2020

Purification, properties and heteromeric association of type-1 and type-2 lepidopteran farnesyl diphosphate synthases

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12 December 2020

Geranyl diphosphate synthase: cloning, expression, and characterization of this prenyltransferase as a heterodimer

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12 December 2020

Conversion from archaeal geranylgeranyl diphosphate synthase to farnesyl diphosphate synthase. Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity

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12 December 2020

BTS1 Encodes a Geranylgeranyl Diphosphate Synthase in Saccharomyces cerevisiae

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12 December 2020

Isolation and functional expression of an animal geranyl diphosphate synthase and its role in bark beetle pheromone biosynthesis

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12 December 2020

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

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12 December 2020

Thermostable farnesyl diphosphate synthase of Bacillus stearothermophilus: molecular cloning, sequence determination, overproduction, and purification

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12 December 2020

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

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12 December 2020

Isoprenyl diphosphate synthases: protein sequence comparisons, a phylogenetic tree, and predictions of secondary structure

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12 December 2020

Crystallization and partial characterization of prenyltransferase from avian liver

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12 December 2020

Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae

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12 December 2020

Cloning and functional analysis of novel short-chain cis-prenyltransferases

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12 December 2020

A role of the amino acid residue located on the fifth position before the first aspartate-rich motif of farnesyl diphosphate synthase on determination of the final product

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12 December 2020

Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases

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12 December 2020

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation †

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12 December 2020

Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase

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12 December 2020

Variable product specificity of microsomal dehydrodolichyl diphosphate synthase from rat liver.

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12 December 2020

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

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12 December 2020

Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate

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12 December 2020

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0

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12 December 2020

In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

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12 December 2020

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies

1 reference

12 December 2020

Studies on the biosynthesis of cholesterol XIX. Steric course of hydrogen eliminations and of C-C bond formations in squalene biosynthesis

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12 December 2020

Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design

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12 December 2020

Overview of bisphosphonates

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12 December 2020

Arabidopsis thaliana contains two differentially expressed farnesyl-diphosphate synthase genes

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12 December 2020

10.1007/S00018-009-0100-9

Identifiers

DOI

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21 August 2017

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