Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal (Q37551606)

21 August 2017

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title

Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal (English)

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21 August 2017

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3

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21 August 2017

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Wendy Dean

2

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21 August 2017

publication date

15 July 2009

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Nature Reviews Molecular Cell Biology

21 August 2017

published in

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21 August 2017

volume

10

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21 August 2017

issue

8

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21 August 2017

page(s)

526-537

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Stability and flexibility of epigenetic gene regulation in mammalian development

21 August 2017

cites work

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Epigenetic events in mammalian germ-cell development: reprogramming and beyond

31 March 2020

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Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer.

31 March 2020

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Genetic and epigenetic regulators of pluripotency

31 March 2020

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Active demethylation of the paternal genome in the mouse zygote

31 March 2020

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Demethylation of the zygotic paternal genome

31 March 2020

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Dynamic reprogramming of DNA methylation in the early mouse embryo.

31 March 2020

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Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene

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The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages

31 March 2020

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The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse

31 March 2020

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Germ cell specification in mice

31 March 2020

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A molecular programme for the specification of germ cell fate in mice

31 March 2020

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Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning

31 March 2020

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Chromatin dynamics during epigenetic reprogramming in the mouse germ line

31 March 2020

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Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.

31 March 2020

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Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice

31 March 2020

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Epigenetic reprogramming in mouse primordial germ cells

31 March 2020

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Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells

31 March 2020

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Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

31 March 2020

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Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

31 March 2020

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DNA demethylation by DNA repair

31 March 2020

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Cellular programming of plant gene imprinting.

31 March 2020

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DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

31 March 2020

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Pericentric heterochromatin reprogramming by new histone variants during mouse spermiogenesis.

31 March 2020

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The profile of repeat-associated histone lysine methylation states in the mouse epigenome

31 March 2020

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

31 March 2020

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Dynamic chromatin modifications characterise the first cell cycle in mouse embryos.

31 March 2020

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Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote

31 March 2020

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PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos

31 March 2020

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Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote

31 March 2020

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Chromosome methylation patterns during mammalian preimplantation development

31 March 2020

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Mechanisms regulating imprinted genes in clusters.

31 March 2020

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Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse.

31 March 2020

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Cell lineage-specific undermethylation of mouse repetitive DNA

31 March 2020

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Undermethylation of structural gene sequences in extraembryonic lineages of the mouse

31 March 2020

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Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes

31 March 2020

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Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity

31 March 2020

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Epigenetic reprogramming in mammals

31 March 2020

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Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

31 March 2020

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Dynamic alterations of specific histone modifications during early murine development

31 March 2020

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Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture

31 March 2020

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Long-term proliferation of mouse primordial germ cells in culture

31 March 2020

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Establishment in culture of pluripotential cells from mouse embryos

31 March 2020

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Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos.

31 March 2020

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Derivation of pluripotent epiblast stem cells from mammalian embryos

31 March 2020

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New cell lines from mouse epiblast share defining features with human embryonic stem cells

31 March 2020

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Reprogramming primordial germ cells into pluripotent stem cells

31 March 2020

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How is pluripotency determined and maintained?

31 March 2020

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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

31 March 2020

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Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data.

31 March 2020

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Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

31 March 2020

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Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells

31 March 2020

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Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

31 March 2020

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Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells

31 March 2020

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Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

31 March 2020

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Transcriptional regulation of nanog by OCT4 and SOX2.

31 March 2020

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Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells

31 March 2020

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

31 March 2020

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Control of developmental regulators by Polycomb in human embryonic stem cells

31 March 2020

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Chromatin signatures of pluripotent cell lines

31 March 2020

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

31 March 2020

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

31 March 2020

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Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation

31 March 2020

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Genome-scale DNA methylation maps of pluripotent and differentiated cells

31 March 2020

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STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells

31 March 2020

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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

31 March 2020

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G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis.

31 March 2020

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De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes

31 March 2020

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Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells

31 March 2020

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Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog

31 March 2020

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Stochastic patterning in the mouse pre-implantation embryo

31 March 2020

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Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo

31 March 2020

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Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

31 March 2020

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Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states

31 March 2020

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Nanog safeguards pluripotency and mediates germline development

31 March 2020

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Spatial distribution and initial changes of SSEA-1 and other cell adhesion-related molecules on mouse embryonic stem cells before and during differentiation

31 March 2020

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Embryonic stem cells expressing both platelet endothelial cell adhesion molecule-1 and stage-specific embryonic antigen-1 differentiate predominantly into epiblast cells in a chimeric embryo.

31 March 2020

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Generation of stella-GFP transgenic mice: a novel tool to study germ cell development

31 March 2020

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Identification and characterization of subpopulations in undifferentiated ES cell culture

31 March 2020

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The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice.

31 March 2020

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Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

31 March 2020

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

31 March 2020

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

31 March 2020

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Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation

31 March 2020

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Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos

31 March 2020

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Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development

31 March 2020

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Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning

31 March 2020

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Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5.

31 March 2020

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Histone H3-K9 methyltransferase ESET is essential for early development

31 March 2020

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The polycomb-group gene Ezh2 is required for early mouse development

31 March 2020

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Histone arginine methylation regulates pluripotency in the early mouse embryo

31 March 2020

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Cell and molecular regulation of the mouse blastocyst

31 March 2020

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The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass

31 March 2020

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Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos

31 March 2020

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Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis.

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

31 March 2020

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Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells

31 March 2020

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Generation of mouse induced pluripotent stem cells without viral vectors

31 March 2020

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Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.

31 March 2020

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Induced pluripotent stem cell lines derived from human somatic cells

31 March 2020

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Dissecting direct reprogramming through integrative genomic analysis

31 March 2020

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A combined chemical and genetic approach for the generation of induced pluripotent stem cells

31 March 2020

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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

31 March 2020

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Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

31 March 2020

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Stochasticity and the molecular mechanisms of induced pluripotency

31 March 2020

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Epigenetic reprogramming and small RNA silencing of transposable elements in pollen

31 March 2020

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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

31 March 2020

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HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

31 March 2020

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Automethylation of G9a and its implication in wider substrate specificity and HP1 binding

31 March 2020

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Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.

31 March 2020

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DNA methyltransferase is actively retained in the cytoplasm during early development

31 March 2020

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Promotion of trophoblast stem cell proliferation by FGF4

31 March 2020

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Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts

31 March 2020

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Multipotent cell lineages in early mouse development depend on SOX2 function

31 March 2020

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Murine inner cell mass-derived lineages depend on Sall4 function

31 March 2020

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Stella is a maternal effect gene required for normal early development in mice

31 March 2020

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Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

31 March 2020

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Eomesodermin is expressed in mouse oocytes and pre-implantation embryos

31 March 2020

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Methylation levels of maternal and paternal genomes during preimplantation development

31 March 2020

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12 December 2020

Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells.

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12 December 2020

Inhibition of trophoblast stem cell potential in chorionic ectoderm coincides with occlusion of the ectoplacental cavity in the mouse.

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12 December 2020

Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells

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12 December 2020

Mitochondria and the death of oocytes

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12 December 2020

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

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12 December 2020

Identifiers

DOI

10.1038/NRM2727

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Dimensions Publication ID

21 August 2017

1022811939

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