Prostaglandin E(2) synthase inhibition as a therapeutic target (Q37521092)

20 August 2017

1 reference

title

Prostaglandin E(2) synthase inhibition as a therapeutic target (English)

1 reference

20 August 2017

Jitesh P Iyer

1

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20 August 2017

Punit K Srivastava

2

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20 August 2017

Rishabh Dev

3

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20 August 2017

Sunanda G Dastidar

4

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20 August 2017

Abhijit Ray

5

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20 August 2017

language of work or name

English

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publication date

1 July 2009

1 reference

Expert Opinion on Therapeutic Targets

20 August 2017

published in

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20 August 2017

volume

13

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20 August 2017

issue

7

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20 August 2017

page(s)

849-865

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Cyclooxygenases: structural, cellular, and molecular biology

20 August 2017

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Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

21 January 2018

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Analgesic strategies beyond the inhibition of cyclooxygenases

21 January 2018

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Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

21 January 2018

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Identification and characterization of a novel type of membrane-associated prostaglandin E synthase

21 January 2018

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Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis

21 January 2018

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Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.

21 January 2018

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Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis

21 January 2018

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Purification and characterization of recombinant microsomal prostaglandin E synthase-1.

21 January 2018

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Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis

21 January 2018

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On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens

21 January 2018

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Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney

21 January 2018

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Cellular prostaglandin E2 production by membrane-bound prostaglandin E synthase-2 via both cyclooxygenases-1 and -2.

21 January 2018

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Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2

21 January 2018

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Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain

21 January 2018

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Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland

21 January 2018

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Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney

21 January 2018

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Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

21 January 2018

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Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases

21 January 2018

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Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3.

21 January 2018

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Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

21 January 2018

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Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis

21 January 2018

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Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes

21 January 2018

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Regulation of cytosolic prostaglandin E synthase by phosphorylation

21 January 2018

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cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis

21 January 2018

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Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.

21 January 2018

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Bioinformatic and enzymatic characterization of the MAPEG superfamily

21 January 2018

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Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

21 January 2018

1 reference

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Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions

21 January 2018

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Human glutathione dependent prostaglandin E synthase: gene structure and regulation

21 January 2018

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Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2

21 January 2018

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Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1.

21 January 2018

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Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1.

21 January 2018

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Involvement of early growth response gene 1 in the modulation of microsomal prostaglandin E synthase 1 by epigallocatechin gallate in A549 human pulmonary epithelial cells

21 January 2018

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Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)gamma agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1beta-stimulated rat chondrocytes: evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12,14pr

21 January 2018

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Prostaglandin E2 is an enhancer of interleukin-1beta-induced expression of membrane-associated prostaglandin E synthase in rheumatoid synovial fibroblasts

21 January 2018

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Prostaglandin E synthase in the pathophysiology of arthritis

21 January 2018

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Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines

21 January 2018

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Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase

21 January 2018

1 reference

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Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile

21 January 2018

1 reference

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Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium

21 January 2018

1 reference

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Induction of microsomal prostaglandin E synthase-1 in human gingival fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Inflammatory response: pathway across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Burn injury enhances brain prostaglandin E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin E synthase in cerebral vascular endothelial cells in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Effect of endotoxin treatment on the expression of cyclooxygenase-2 and prostaglandin synthases in spinal cord, dorsal root ganglia, and skin of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Host cyclooxygenase-2 modulates carcinoma growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Luminal NaCl delivery regulates basolateral PGE2 release from macula densa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Induction of microsomal prostaglandin E2 synthase in the macula densa in children with hypokalemic salt-losing tubulopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Multiple female reproductive failures in cyclooxygenase 2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Prostaglandin E2 is a product of induced prostaglandin-endoperoxide synthase 2 and microsomal-type prostaglandin E synthase at the implantation site of the hamster

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Differential localization of prostaglandin E synthase isoforms in human placental cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Differential expression of microsomal prostaglandin e synthase at implantation sites and in decidual cells of mouse uterus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Expression of Membrane Prostaglandin E Synthase in Human Placenta and Fetal Membranes and Effect of Labor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Prostaglandin E synthases in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 up-regulation in wild-type anorexic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Prostaglandin E synthase: a novel drug target for inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220903018932

10.1517/14728220903018932

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference