MAPK signaling pathways in the regulation of hematopoiesis (Q37508518)

20 August 2017

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title

MAPK signaling pathways in the regulation of hematopoiesis (English)

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20 August 2017

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Christian R Geest

1

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20 August 2017

Paul J Coffer

series ordinal

2

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20 August 2017

publication date

4 June 2009

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Journal of Leukocyte Biology

20 August 2017

published in

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20 August 2017

volume

86

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20 August 2017

issue

2

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20 August 2017

page(s)

237-250

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Mammalian MAP kinase signalling cascades

20 August 2017

cites work

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MAP kinases in the immune response

21 January 2018

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Mitogen-activated protein kinases in apoptosis regulation

21 January 2018

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Mitogen-activated protein kinases: specific messages from ubiquitous messengers

21 January 2018

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Signal transduction by the JNK group of MAP kinases

21 January 2018

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Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

21 January 2018

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Activation and signaling of the p38 MAP kinase pathway

21 January 2018

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How MAP kinases are regulated

21 January 2018

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Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

21 January 2018

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Docking interactions in the mitogen-activated protein kinase cascades

21 January 2018

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Molecular recognitions in the MAP kinase cascades

21 January 2018

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

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Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

21 January 2018

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Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis

21 January 2018

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MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade

21 January 2018

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MEKK1 binds raf-1 and the ERK2 cascade components

21 January 2018

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MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

21 January 2018

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

21 January 2018

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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

21 January 2018

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

21 January 2018

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A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

21 January 2018

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The JIP group of mitogen-activated protein kinase scaffold proteins

21 January 2018

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Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

21 January 2018

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Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

21 January 2018

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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes

21 January 2018

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Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

21 January 2018

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JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation

21 January 2018

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Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways

21 January 2018

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Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

21 January 2018

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Differential regulation and properties of MAPKs

21 January 2018

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A mammalian scaffold complex that selectively mediates MAP kinase activation

21 January 2018

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KSR modulates signal propagation within the MAPK cascade

21 January 2018

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Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

21 January 2018

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Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase

21 January 2018

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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

21 January 2018

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21 January 2018

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The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

21 January 2018

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MAP kinases and the control of nuclear events

21 January 2018

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Differentiation of CD4 T cells to Th1 cells requires MAP kinase JNK2.

21 January 2018

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The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

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Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities

21 January 2018

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Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently

21 January 2018

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STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

21 January 2018

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Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck

21 January 2018

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Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

21 January 2018

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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

21 January 2018

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MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

21 January 2018

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Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

21 January 2018

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Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

21 January 2018

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Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

21 January 2018

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Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation.

21 January 2018

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Phosphorylation of c-jun mediated by MAP kinases.

21 January 2018

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Transcription factor ATF2 regulation by the JNK signal transduction pathway

21 January 2018

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Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation

21 January 2018

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Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

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c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability.

21 January 2018

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Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling

21 January 2018

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FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

21 January 2018

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Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

21 January 2018

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JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

21 January 2018

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JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

21 January 2018

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JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

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Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

21 January 2018

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Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1.

21 January 2018

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Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.

21 January 2018

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Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

21 January 2018

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Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis

21 January 2018

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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

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Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

21 January 2018

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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

21 January 2018

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Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

21 January 2018

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ERK implication in cell cycle regulation

21 January 2018

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

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An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

21 January 2018

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Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

21 January 2018

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c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

21 January 2018

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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

21 January 2018

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

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Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

21 January 2018

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Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

21 January 2018

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Generation and characterization of p38beta (MAPK11) gene-targeted mice.

21 January 2018

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p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP

21 January 2018

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Functions of the MAPK family in vertebrate-development

21 January 2018

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Essential role for ERK2 mitogen-activated protein kinase in placental development

21 January 2018

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Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line

21 January 2018

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Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway

21 January 2018

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Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase

21 January 2018

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A Role for the MEK/MAPK Pathway in PMA-Induced Cell Cycle Arrest: Modulation of Megakaryocytic Differentiation of K562 Cells

21 January 2018

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PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events

21 January 2018

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Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

21 January 2018

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Phosphorylation of C/EBPalpha inhibits granulopoiesis

21 January 2018

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Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment

21 January 2018

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Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1

21 January 2018

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GATA transcription factors and hematological diseases

21 January 2018

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Mitogen-activated protein kinase mediates erythropoietin-induced phosphorylation of the TAL1/SCL transcription factor in murine proerythroblasts

21 January 2018

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Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1

21 January 2018

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Signalling, cell cycle and pluripotency in embryonic stem cells

21 January 2018

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Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases

21 January 2018

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FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment

21 January 2018

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A critical function for B-Raf at multiple stages of myelopoiesis

21 January 2018

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Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin signaling

21 January 2018

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UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis

21 January 2018

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TRAIL regulates normal erythroid maturation through an ERK-dependent pathway

21 January 2018

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

21 January 2018

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Signal transduction by tumor necrosis factor mediated by JNK protein kinases

21 January 2018

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Physiological roles of MKK4 and MKK7: insights from animal models

21 January 2018

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

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Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

21 January 2018

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Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines

21 January 2018

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MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver.

21 January 2018

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AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells

21 January 2018

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Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination.

21 January 2018

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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

21 January 2018

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CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors

21 January 2018

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C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1

21 January 2018

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Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

21 January 2018

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The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.

21 January 2018

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A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK

21 January 2018

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Hematopoietic cells from gadd45a-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation.

21 January 2018

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Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation.

21 January 2018

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Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

21 January 2018

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p38 MAP kinases: beyond the stress response

21 January 2018

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The p38 signal transduction pathway: activation and function

21 January 2018

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Functions of MAP kinases: insights from gene-targeting studies

21 January 2018

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Functional regulation of TEL by p38-induced phosphorylation

21 January 2018

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The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

21 January 2018

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Different levels of p38 MAP kinase activity mediate distinct biological effects in primary human erythroid progenitors

21 January 2018

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Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation

21 January 2018

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Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells

21 January 2018

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Role of the p38 mitogen-activated protein kinase pathway in cytokine-mediated hematopoietic suppression in myelodysplastic syndromes

21 January 2018

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Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors.

21 January 2018

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Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis

21 January 2018

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Role of p38alpha Map kinase in Type I interferon signaling

21 January 2018

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Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis

21 January 2018

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Role of p38 in regulation of hematopoiesis: effect of p38 inhibition on cytokine production and transcription factor activity in human bone marrow stromal cells

21 January 2018

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Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations

21 January 2018

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

21 January 2018

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A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

21 January 2018

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Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34 CD133 cord blood cells.

21 January 2018

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Map kinase signaling pathways and hematologic malignancies

21 January 2018

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Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis

21 January 2018

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Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

21 January 2018

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

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MEK blockade converts AML differentiating response to retinoids into extensive apoptosis

21 January 2018

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An investigation of the MEK/ERK inhibitor U0126 in acute myeloid leukemia

21 January 2018

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An investigation of the effects of the MEK inhibitor U0126 on apoptosis in acute leukemia

21 January 2018

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Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

21 January 2018

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MEK1/2 inhibitors sensitize Bcr/Abl human leukemia cells to the dual Abl/Src inhibitor BMS-354/825

21 January 2018

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

21 January 2018

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Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

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MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

21 January 2018

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p38 mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromes

21 January 2018

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The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

21 January 2018

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The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner

21 January 2018

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Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation

21 January 2018

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Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation

21 January 2018

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c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia

21 January 2018

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Integration of MAP kinase signal transduction pathways at the serum response element

21 January 2018

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Defective T Cell Differentiation in the Absence of Jnk1

21 January 2018

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21 January 2018

Identifiers

DOI

10.1189/JLB.0209097

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20 August 2017

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