Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology. (Q37504904)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27974048 AND SRC:MED&resulttype=core&format=json

29 March 2020

title

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology (English)

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29 March 2020

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7

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29 March 2020

Kiran Bhaskar

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29 March 2020

6

Linda J Van Eldik

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29 March 2020

author name string

Nicole Maphis

1

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29 March 2020

Shanya Jiang

2

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29 March 2020

Guixiang Xu

3

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29 March 2020

Olga N Kokiko-Cochran

4

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29 March 2020

Saktimayee M Roy

5

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29 March 2020

Bruce T Lamb

8

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29 March 2020

language of work or name

English

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publication date

15 December 2016

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Alzheimers Research & Therapy

29 March 2020

published in

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29 March 2020

volume

8

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29 March 2020

issue

1

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29 March 2020

page(s)

54

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

29 March 2020

cites work

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor

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Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy.

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The potential and limitations of p38MAPK as a drug target for the treatment of hematological malignancies

23 August 2017

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Pathological roles of MAPK signaling pathways in human diseases

23 August 2017

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Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology

23 August 2017

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The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events

23 August 2017

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Tau impacts on growth-factor-stimulated actin remodeling.

23 August 2017

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p38 MAPK in development and cancer

23 August 2017

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The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory

23 August 2017

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Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

23 August 2017

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Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation

23 August 2017

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Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia

23 August 2017

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SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

23 August 2017

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Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

23 August 2017

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23 August 2017

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6 September 2017

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Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling

6 September 2017

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Protein phosphorylation in neurodegeneration: friend or foe?

6 September 2017

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Molecular basis of MAP kinase regulation

6 September 2017

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The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease

6 September 2017

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p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta

6 September 2017

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A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.

14 September 2017

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2-Deoxy-D-ribose inhibits hypoxia-induced apoptosis by suppressing the phosphorylation of p38 MAPK.

14 September 2017

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Generation and characterization of p38beta (MAPK11) gene-targeted mice.

14 September 2017

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Phosphorylation of tau by fyn: implications for Alzheimer's disease.

14 September 2017

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14 September 2017

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Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα

28 September 2017

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Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures.

26 June 2018

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26 June 2018

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26 June 2018

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Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.

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Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

2 September 2018

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2 September 2018

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Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult

2 September 2018

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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

2 September 2018

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Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects

2 September 2018

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SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

2 September 2018

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Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

2 September 2018

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Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1G93A-induced motor neuron death

2 September 2018

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Crossref

https://api.crossref.org/works/10.1186/S13195-016-0221-Y

SB203580, a p38 mitogen-activated protein kinase inhibitor, fails to improve functional outcome following a moderate spinal cord injury in rat

21 January 2018

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12 December 2020

Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis

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12 December 2020

p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection

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12 December 2020

Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes

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12 December 2020

Microfilament-associated growth cone component depends upon Tau for its intracellular localization

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12 December 2020

MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

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12 December 2020

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence

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12 December 2020

Acute inactivation of tau has no effect on dynamics of microtubules in growing axons of cultured sympathetic neurons

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12 December 2020

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

12 December 2020

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27974048 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27974048 AND SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

27974048

1 reference