Targeting histone deacetylases for heart failure (Q37494673)

20 August 2017

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title

Targeting histone deacetylases for heart failure (English)

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20 August 2017

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Erik W Bush

1

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20 August 2017

Timothy A McKinsey

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

1 July 2009

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Expert Opinion on Therapeutic Targets

20 August 2017

published in

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20 August 2017

volume

13

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20 August 2017

issue

7

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20 August 2017

page(s)

767-784

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Acetylation and deacetylation of non-histone proteins

20 August 2017

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YY1 protects cardiac myocytes from pathologic hypertrophy by interacting with HDAC5

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Protein kinase D signaling

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AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway

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Ca2 /calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7.

21 January 2018

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Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy

21 January 2018

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Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes

21 January 2018

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Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis

21 January 2018

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Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus

21 January 2018

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Interleukin-2 transcriptional block by multifunctional Ca2 /calmodulin kinase

21 January 2018

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Role of Ca2 /calmodulin-dependent kinases in skeletal muscle plasticity

21 January 2018

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21 January 2018

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Control of muscle development by dueling HATs and HDACs

21 January 2018

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Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.

21 January 2018

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SUMOylation substrates in neuronal intranuclear inclusion disease

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Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death.

21 January 2018

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HDAC4 inhibits cell-cycle progression and protects neurons from cell death

21 January 2018

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Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction

21 January 2018

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Neuroprotection by histone deacetylase-related protein

21 January 2018

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Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

21 January 2018

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Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2 ) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival

21 January 2018

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Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

21 January 2018

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Bone morphogenetic protein-2 stimulates Runx2 acetylation

21 January 2018

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Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

21 January 2018

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Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity

21 January 2018

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HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis

21 January 2018

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Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor-induced Nur77 expression and apoptosis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Kinetics and comparative reactivity of human class I and class IIb histone deacetylases

21 January 2018

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Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

21 January 2018

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Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

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Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

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Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

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Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy

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Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy

21 January 2018

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21 January 2018

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HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3.

21 January 2018

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Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop

21 January 2018

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Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding

21 January 2018

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Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy

21 January 2018

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Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure

21 January 2018

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Myocyte apoptosis in heart failure.

21 January 2018

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Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

21 January 2018

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Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injury

21 January 2018

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Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury

21 January 2018

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Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts

21 January 2018

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Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin

21 January 2018

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Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells

21 January 2018

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Epigenetic regulation of airway inflammation.

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Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?

21 January 2018

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Myosin heavy chain isoform expression in the failing and nonfailing human heart

21 January 2018

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Myosin heavy chain gene expression in human heart failure

21 January 2018

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Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments

21 January 2018

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Power output is linearly related to MyHC content in rat skinned myocytes and isolated working hearts

21 January 2018

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Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions

21 January 2018

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Control of cardiac myosin heavy chain gene expression

21 January 2018

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Concurrent opposite effects of trichostatin A, an inhibitor of histone deacetylases, on expression of alpha-MHC and cardiac tubulins: implication for gain in cardiac muscle contractility

21 January 2018

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Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

21 January 2018

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A review of depsipeptide and other histone deacetylase inhibitors in clinical trials

21 January 2018

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A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

21 January 2018

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Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6

21 January 2018

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Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer

21 January 2018

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Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

21 January 2018

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Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast*.

21 January 2018

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Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

21 January 2018

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Transcription therapy for acute promyelocytic leukaemia

21 January 2018

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Transcription therapy for cancer

21 January 2018

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New therapeutic targets in cancer: the epigenetic connection

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Histone deacetylase inhibition and estrogen signalling in human breast cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Potentiation of androgen receptor transcriptional activity by inhibition of histone deacetylation--rescue of transcriptionally compromised mutants

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Histone deacetylase inhibitors: a novel therapeutic approach to Huntington's disease (complex mechanism of neuronal death).

21 January 2018

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Challenges and opportunities in clinical trials for spinal muscular atrophy

21 January 2018

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Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

The role of the cytoskeleton in heart failure

21 January 2018

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

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The ubiquitin-proteasome system: focus on the heart.

21 January 2018

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Into the heart: the emerging role of the ubiquitin-proteasome system.

21 January 2018

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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

21 January 2018

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

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Using Yeast to Discover the Fountain of Youth

21 January 2018

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https://api.crossref.org/works/10.1517/14728220902939161

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

DNA repair, genome stability, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Sirt1 regulates aging and resistance to oxidative stress in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Effects of intravenous ABT-870 (iron (III)-hydroxide oligosaccharide) on mean arterial pressure and heart rate in the anaesthetized beagle: comparison with other iron-containing haematinic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Resveratrol: one molecule, many targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Local InsP3-dependent perinuclear Ca2 signaling in cardiac myocyte excitation-transcription coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Myocyte Enhancer Factors 2A and 2C Induce Dilated Cardiomyopathy in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517/14728220902939161

10.1517/14728220902939161

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference