S-2-hydroxyglutarate regulates CD8 T-lymphocyte fate. (Q37491480)

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26 March 2020

title

S-2-hydroxyglutarate regulates CD8 T-lymphocyte fate (English)

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26 March 2020

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2

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David Macias

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Kian Leong Lee

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Pedro Veliça

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Andrew Doedens

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Randall S. Johnson

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26 March 2020

author name string

Petros A Tyrakis

1

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Anthony T Phan

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Jia You

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Grace S Chia

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Jingwei Sim

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Alice Abelanet

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Colin E Evans

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John R Griffiths

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Lorenz Poellinger

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Ananda W Goldrath

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26 March 2020

language of work or name

English

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publication date

26 October 2016

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26 March 2020

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26 March 2020

volume

540

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26 March 2020

issue

7632

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26 March 2020

page(s)

236-241

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Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

26 March 2020

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Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation

23 August 2017

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Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

23 August 2017

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Hypoxia Induces Production of L-2-Hydroxyglutarate.

23 August 2017

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Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

23 August 2017

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

23 August 2017

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Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

23 August 2017

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Lineage relationship of CD8( ) T cell subsets is revealed by progressive changes in the epigenetic landscape

23 August 2017

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The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

23 August 2017

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Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8( ) T cell differentiation

23 August 2017

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5-Hydroxymethylcytosine is a predominantly stable DNA modification.

23 August 2017

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HIF transcription factors, inflammation, and immunity

23 August 2017

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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

23 August 2017

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Memory CD8( ) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

23 August 2017

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Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection

23 August 2017

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Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

23 August 2017

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Epigenetic plasticity of Cd8a locus during CD8( ) T-cell development and effector differentiation and reprogramming

23 August 2017

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Early specification of CD8 T lymphocyte fates during adaptive immunity revealed by single-cell gene-expression analyses.

23 August 2017

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Hypoxia-inducible factors enhance the effector responses of CD8( ) T cells to persistent antigen.

23 August 2017

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Posttranscriptional control of T cell effector function by aerobic glycolysis

23 August 2017

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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

23 August 2017

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Metabolic regulation of T lymphocytes

23 August 2017

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Transcriptional control of effector and memory CD8 T cell differentiation

23 August 2017

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

23 August 2017

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

23 August 2017

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

23 August 2017

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

23 August 2017

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

23 August 2017

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

23 August 2017

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

23 August 2017

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

23 August 2017

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mTOR regulates memory CD8 T-cell differentiation

23 August 2017

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Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8 T cells

23 August 2017

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

23 August 2017

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High-resolution profiling of histone methylations in the human genome

23 August 2017

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Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8 T cells

23 August 2017

1 reference

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Bcl-6 directly represses the gene program of the glycolysis pathway

23 August 2017

1 reference

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Metabolism of stromal and immune cells in health and disease

6 September 2017

1 reference

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis

6 September 2017

1 reference

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

Stable-isotope dilution analysis of D- and L-2-hydroxyglutaric acid: application to the detection and prenatal diagnosis of D- and L-2-hydroxyglutaric acidemias

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

Bcl-2 allows effector and memory CD8 T cells to tolerate higher expression of Bim.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen

2 September 2018

1 reference

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Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.

2 September 2018

1 reference

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Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8 T cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

Persistence of memory CD8 T cells in MHC class I-deficient mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5149074

2 September 2018

Identifiers

DOI

10.1038/NATURE20165

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26 March 2020

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26 March 2020

PubMed publication ID

27798602

1 reference