PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. (Q37392187)

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6 February 2020

title

PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM (English)

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6 February 2020

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5

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6 February 2020

author name string

Michael J Carrozza

1

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6 February 2020

Donna F Stefanick

2

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6 February 2020

Julie K Horton

3

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6 February 2020

Padmini S Kedar

4

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publication date

31 August 2009

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6 February 2020

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6 February 2020

volume

8

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issue

11

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6 February 2020

page(s)

1264-1272

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Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

6 February 2020

cites work

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6 September 2017

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Base excision DNA repair

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XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks

6 September 2017

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PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

6 September 2017

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Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy

6 September 2017

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The ATR pathway: fine-tuning the fork

6 September 2017

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Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition

6 September 2017

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ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.

6 September 2017

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Topoisomerase I inhibitors: camptothecins and beyond

6 September 2017

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Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

6 September 2017

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

6 September 2017

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Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy

6 September 2017

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Targeting chk2 kinase: molecular interaction maps and therapeutic rationale

6 September 2017

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Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes

6 September 2017

1 reference

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

6 September 2017

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

6 September 2017

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

6 September 2017

1 reference

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Caffeine and human DNA metabolism: the magic and the mystery

6 September 2017

1 reference

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763951

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763951

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

6 September 2017

1 reference

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Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair

6 September 2017

1 reference

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BRCA2 is required for homology-directed repair of chromosomal breaks

6 September 2017

1 reference

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Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

6 September 2017

1 reference

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Brca1 controls homology-directed DNA repair

6 September 2017

1 reference

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Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

6 September 2017

1 reference

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Role of poly(ADP-ribose) formation in DNA repair

6 September 2017

1 reference

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Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks

6 September 2017

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The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR.

14 September 2017

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Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

14 September 2017

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ATR dependent activation of Chk2.

14 September 2017

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ATM is required for the cellular response to thymidine induced replication fork stress.

14 September 2017

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Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors

14 September 2017

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

14 September 2017

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Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions

14 September 2017

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Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.

14 September 2017

1 reference

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The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

28 September 2017

1 reference

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

28 September 2017

1 reference

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Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763951

Recombinant ATM protein complements the cellular A-T phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763951

Requirement of mammalian DNA polymerase-beta in base-excision repair.

28 September 2017

1 reference

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Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents

28 September 2017

1 reference

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Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle

26 June 2018

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The ATM-mediated DNA-damage response: taking shape.

26 June 2018

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Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles

2 September 2018

1 reference

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Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.

2 September 2018

1 reference

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Regulation of CHK2 by DNA-dependent protein kinase

2 September 2018

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Involvement of DNA polymerase beta in protection against the cytotoxicity of oxidative DNA damage.

2 September 2018

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Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

2 September 2018

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NAD( )-dependent repair of damaged DNA by human cell extracts

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19717351

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DNAREP.2009.07.010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19717351 AND SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19717351 AND SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

19717351

1 reference