A genomic screen identifies TYRO3 as a MITF regulator in melanoma. (Q37386014)

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9 February 2020

title

A genomic screen identifies TYRO3 as a MITF regulator in melanoma (English)

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5

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Costas A Lyssiotis

7

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14

Peter G Schultz

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2

Heiko Wurdak

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9 February 2020

author name string

Shoutian Zhu

1

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9 February 2020

Yan Wang

3

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Anna Galkin

4

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Jie Li

6

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9 February 2020

Feng Yan

8

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Buu P Tu

9

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Loren Miraglia

10

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9 February 2020

John Walker

11

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Fanxiang Sun

12

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Anthony Orth

13

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Xu Wu

15

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language of work or name

English

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publication date

23 September 2009

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Proceedings of the National Academy of Sciences of the United States of America

9 February 2020

published in

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9 February 2020

volume

106

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issue

40

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9 February 2020

page(s)

17025-17030

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Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.

9 February 2020

cites work

1 reference

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6 September 2017

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Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas

6 September 2017

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Immunobiology of the TAM receptors

6 September 2017

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How to make a melanoma: what do we know of the primary clonal events?

6 September 2017

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Growth arrest-specific gene 6 expression in human breast cancer.

6 September 2017

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Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells

6 September 2017

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Clonogenic assay of cells in vitro.

6 September 2017

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Melanocyte biology and skin pigmentation

6 September 2017

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New insight into BRAF mutations in cancer

6 September 2017

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Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.

6 September 2017

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Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.

6 September 2017

1 reference

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Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

6 September 2017

1 reference

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Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival

6 September 2017

1 reference

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BRAF somatic mutations in malignant melanoma and melanocytic naevi

6 September 2017

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Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

6 September 2017

1 reference

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Radiation therapy following lymph node dissection in melanoma patients: treatment, outcome and complications

6 September 2017

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Melanocytes and the microphthalmia transcription factor network

6 September 2017

1 reference

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A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes

6 September 2017

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The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia

6 September 2017

1 reference

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Metastatic melanoma: chemotherapy

6 September 2017

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Acidification prevents endothelial cell apoptosis by Axl activation

6 September 2017

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Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor

6 September 2017

1 reference

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

6 September 2017

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Large-scale analysis of the human and mouse transcriptomes

6 September 2017

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Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma

6 September 2017

1 reference

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Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3

6 September 2017

1 reference

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Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.

6 September 2017

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c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

6 September 2017

1 reference

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Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway

6 September 2017

1 reference

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Microphthalmia transcription factor. A sensitive and specific melanocyte marker for MelanomaDiagnosis

6 September 2017

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Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocations

6 September 2017

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Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

6 September 2017

1 reference

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Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.

6 September 2017

1 reference

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The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

6 September 2017

1 reference

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Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

6 September 2017

1 reference

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Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

AXL is a potential target for therapeutic intervention in breast cancer progression.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Mer receptor tyrosine kinase signaling: prevention of apoptosis and alteration of cytoskeletal architecture without stimulation or proliferation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Gas 6 promotes Axl-mediated survival in pulmonary endothelial cells

28 September 2017

1 reference

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The first laminin G-type domain in the SHBG-like region of protein S contains residues essential for activation of the receptor tyrosine kinase sky.

28 September 2017

1 reference

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Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Mouse mammary tumors express elevated levels of RNA encoding the murine homology of SKY, a putative receptor tyrosine kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Stimulation of sky receptor tyrosine kinase by the product of growth arrest-specific gene 6.

28 September 2017

1 reference

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Stimulation of Sky tyrosine phosphorylation by bovine protein S--domains involved in the receptor-ligand interaction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

A receptor tyrosine kinase, Sky, and its ligand Gas 6 are expressed in gonads and support primordial germ cell growth or survival in culture.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2761329

Synthesis and secretion of the anticoagulant protein S and coexpression of the Tyro3 receptor in human lung carcinoma cells

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19805117

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0909292106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19805117 AND SRC:MED&resulttype=core&format=json

9 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19805117 AND SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

19805117

1 reference