Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells (Q37383135)

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English	Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

20 August 2017

Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells (English)

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Europe PubMed Central

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20 August 2017

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G R Post

1

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Europe PubMed Central

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20 August 2017

L R Collins

2

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Europe PubMed Central

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20 August 2017

E D Kennedy

3

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Europe PubMed Central

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20 August 2017

S A Moskowitz

4

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Europe PubMed Central

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20 August 2017

A M Aragay

5

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20 August 2017

D Goldstein

6

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20 August 2017

J H Brown

7

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20 August 2017

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1 November 1996

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20 August 2017

Molecular Biology of the Cell

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Europe PubMed Central

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20 August 2017

7

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20 August 2017

11

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Europe PubMed Central

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20 August 2017

1679-1690

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Europe PubMed Central

PMC publication ID

20 August 2017

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

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6 September 2017

Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor

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6 September 2017

Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity

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6 September 2017

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

G alpha 13 stimulates Na-H exchange.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

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6 September 2017

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

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6 September 2017

Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts

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6 September 2017

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

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6 September 2017

Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor

1 reference

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6 September 2017

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein

1 reference

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6 September 2017

Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors

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6 September 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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6 September 2017

The mas oncogene encodes an angiotensin receptor

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6 September 2017

alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.

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6 September 2017

Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

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6 September 2017

Growth factors, signaling pathways, and the regulation of proliferation and differentiation in BC3H1 muscle cells. II. Two signaling pathways distinguished by pertussis toxin and a potential role for the ras oncogene

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6 September 2017

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits

1 reference

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6 September 2017

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor

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6 September 2017

Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes

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6 September 2017

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1

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6 September 2017

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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6 September 2017

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells

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6 September 2017

A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells

1 reference

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6 September 2017

Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: differential effects of muscarinic and thrombin receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

6 September 2017

Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor

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6 September 2017

The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors.

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14 September 2017

G protein-coupled receptors and signaling pathways regulating growth responses.

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28 September 2017

Cellular consequences of thrombin-receptor activation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

28 September 2017

Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.

1 reference

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28 September 2017

cAMP-mediated growth inhibition in fibroblasts is not mediated via mitogen-activated protein (MAP) kinase (ERK) inhibition. cAMP-dependent protein kinase induces a temporal shift in growth factor-stimulated MAP kinases

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28 September 2017

G alpha 13 stimulates Na -H exchange through distinct Cdc42-dependent and RhoA-dependent pathways

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28 September 2017

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

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28 September 2017

G protein beta gamma subunit activates Ras, Raf, and MAP kinase in HEK 293 cells

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28 September 2017

A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells

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26 June 2018

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

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26 June 2018

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

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26 June 2018

Protein kinase C-dependent and -independent activation of Na /H exchanger by G alpha 12 class of G proteins.

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26 June 2018

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells

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26 June 2018

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts

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26 June 2018

Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells.

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26 June 2018

Inhibition by cAMP of Ras-Dependent Activation of Raf

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26 June 2018

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

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26 June 2018

Pertussis toxin-sensitive pathway in the stimulation of c-myc expression and DNA synthesis by bombesin

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26 June 2018

Desensitization and recovery of muscarinic and histaminergic Ca2 mobilization in 1321N1 astrocytoma cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Platelet adenylate cyclase and phospholipase C are affected differentially by ADP-ribosylation. Effects on thrombin-mediated responses

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26 June 2018

Evidence for two GTPases activated by thrombin in membranes of human platelets

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26 June 2018

Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Increases in intracellular Ca2 regulate the binding of [3H]phorbol 12,13-dibutyrate to intact 1321N1 astrocytoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization.

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26 June 2018

Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine recepto

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Dissociation of protein kinase C redistribution from the phosphorylation of its substrates

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Development of an antiserum against m3 muscarinic receptors: distribution of m3 receptors in rat tissues and clonal cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Inhibition of tyrosine phosphorylation prevents thrombin-induced mitogenesis, but not intracellular free calcium release, in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=276018

26 June 2018

Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1

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26 June 2018

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase

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26 June 2018

Acetylcholine as a mitogen: muscarinic receptor-mediated proliferation of rat astrocytes and human astrocytoma cells

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2 September 2018

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

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2 September 2018

Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation

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2 September 2018

G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells

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2 September 2018

Relationships between phosphoinositide and calcium responses to muscarinic agonists in astrocytoma cells

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2 September 2018

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

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2 September 2018

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition

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12 December 2020

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Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway

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https://pubmed.ncbi.nlm.nih.gov/8930892

12 December 2020

based on heuristic

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Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

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https://pubmed.ncbi.nlm.nih.gov/8930892

12 December 2020

based on heuristic

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Binding of G protein beta gamma-subunits to pleckstrin homology domains

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https://pubmed.ncbi.nlm.nih.gov/8930892

12 December 2020

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Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate

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https://pubmed.ncbi.nlm.nih.gov/8930892

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1091/MBC.7.11.1679

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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