Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. (Q37379113)

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scientific article published on July 2009

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English	Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway.	scientific article published on July 2009

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3 February 2020

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Europe PubMed Central

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway (English)

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3 February 2020

3

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3 February 2020

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Kim-Son H Nguyen

1

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3 February 2020

Susumu Kobayashi

2

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1 July 2009

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3 February 2020

Clinical Lung Cancer

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3 February 2020

281-289

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3 February 2020

Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer.

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Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

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BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

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Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

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MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

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Phase II study of erlotinib in advanced non-small-cell lung cancer after failure of gefitinib.

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Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib.

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Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

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Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma

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EGFR mutation and response of lung cancer to gefitinib

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Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758558

2 September 2018

Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758558

2 September 2018

Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2758558

2 September 2018

Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19632948

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19632948

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19632948

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3816/CLC.2009.N.039

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19632948 AND SRC:MED&resulttype=core&format=json

3 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19632948 AND SRC:MED&resulttype=core&format=json

3 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19632948 AND SRC:MED&resulttype=core&format=json

3 February 2020

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