Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism. (Q37374258)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9410902 AND SRC:MED&resulttype=core&format=json

8 November 2019

title

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism (English)

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8 November 2019

9

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8 November 2019

Bhagirath Singh

12

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8 November 2019

author name string

G A Arreaza

1

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8 November 2019

M J Cameron

2

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8 November 2019

A Jaramillo

3

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8 November 2019

B M Gill

4

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8 November 2019

D Hardy

5

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8 November 2019

K B Laupland

6

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8 November 2019

M J Rapoport

7

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8 November 2019

P Zucker

8

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8 November 2019

S W Chensue

10

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8 November 2019

H Y Qin

11

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8 November 2019

T L Delovitch

13

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8 November 2019

language of work or name

English

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publication date

1 November 1997

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Journal of Clinical Investigation

8 November 2019

published in

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8 November 2019

volume

100

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8 November 2019

issue

9

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8 November 2019

page(s)

2243-2253

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The function of costimulatory molecules and the development of IL-4-producing T cells

8 November 2019

cites work

1 reference

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Limited role of CD28-mediated signals in T helper subset differentiation

6 September 2017

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Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice

6 September 2017

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Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation

6 September 2017

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Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

6 September 2017

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Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

6 September 2017

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

6 September 2017

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6 September 2017

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6 September 2017

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Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4 and Lyt-2 T cells.

6 September 2017

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T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice

6 September 2017

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6 September 2017

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T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

6 September 2017

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6 September 2017

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The role of CD4 and CD8 T cells in the destruction of islet grafts by spontaneously diabetic mice

6 September 2017

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6 September 2017

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Insulin dependent diabetes mellitus in the non-obese diabetic mouse: a disease mediated by T cell anergy?

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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28 September 2017

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26 June 2018

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26 June 2018

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26 June 2018

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Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells

26 June 2018

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26 June 2018

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26 June 2018

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Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

26 June 2018

1 reference

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Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1.

26 June 2018

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Acceleration of diabetes in young NOD mice with a CD4 islet-specific T cell clone

26 June 2018

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IL-4 increases IL-2 production by T cells in response to accessory cell-independent stimuli

26 June 2018

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Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis

26 June 2018

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Regulation of interleukin-4 production in human mononuclear cells.

26 June 2018

1 reference

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Identification and distribution of the costimulatory receptor CD28 in the mouse

26 June 2018

1 reference

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Long term culture of tumour-specific cytotoxic T cells

26 June 2018

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Pathogenic and protective roles of CD45RB(low) CD4 cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse

26 June 2018

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Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

2 September 2018

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Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

2 September 2018

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Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice

2 September 2018

1 reference

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IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

2 September 2018

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Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis

2 September 2018

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IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

2 September 2018

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B7-2 (CD86) is essential for the development of IL-4-producing T cells

2 September 2018

1 reference

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CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation

2 October 2018

1 reference

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CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes

2 October 2018

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Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing T helper cells does not require exogenous IL-4

2 October 2018

1 reference

12 December 2020

T helper cell subsets in insulin-dependent diabetes

1 reference

12 December 2020

Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines

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12 December 2020

Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus

1 reference

12 December 2020

Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies

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12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4 and CD8 T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

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12 December 2020

Altered cytokine activity in adjuvant inhibition of autoimmune diabetes

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12 December 2020

CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis

1 reference

12 December 2020

Stability of Th1 and Th2 populations

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12 December 2020

CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response

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12 December 2020

Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin

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12 December 2020

Insulin-dependent diabetes mellitus

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12 December 2020

Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis

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12 December 2020

Induction of autoimmunity in the absence of CD28 costimulation

1 reference

12 December 2020

Early quantitative and functional deficiency of NK1 -like thymocytes in the NOD mouse

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12 December 2020

CD28 costimulation promotes the production of Th2 cytokines

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12 December 2020

CD28 ligation prevents bacterial toxin-induced septic shock in mice by inducing IL-10 expression

1 reference

12 December 2020

Role of IL-12 and 4-1BB ligand in cytokine production by CD28 and CD28- T cells

1 reference

12 December 2020

Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse

1 reference

12 December 2020

Immunization With the Larger Isoform of Mouse Glutamic Acid Decarboxylase (GAD67) Prevents Autoimmune Diabetes in NOD Mice

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12 December 2020

The pathogenesis of insulin-dependent diabetes mellitus

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12 December 2020

CD28 activation promotes Th2 subset differentiation by human CD4 cells

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12 December 2020

Identifiers

DOI

10.1172/JCI119762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9410902 AND SRC:MED&resulttype=core&format=json

8 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9410902 AND SRC:MED&resulttype=core&format=json

8 November 2019

PubMed publication ID

9410902

1 reference