Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model (Q37362443)

19 August 2017

Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model (English)

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regulation of protein localization to lysosome

19 August 2017

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0150031

negative regulation of protein localization to lysosome

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0150033

Rho associated coiled-coil containing protein kinase 1

1 reference

Rho associated coiled-coil containing protein kinase 2

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Beta-secretase 1

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negative regulation of amyloid precursor protein catabolic process

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Rho-associated coiled-coil containing protein kinase 2

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1 reference

9

Madhav Thambisetty

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19 August 2017

7

Thomas J Montine

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19 August 2017

Jeremy H Herskowitz

1

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19 August 2017

Yangbo Feng

2

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19 August 2017

Alexa L Mattheyses

3

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19 August 2017

Chadwick M Hales

4

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19 August 2017

Lenora A Higginbotham

5

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19 August 2017

Duc M Duong

6

1 reference

19 August 2017

Juan C Troncoso

8

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19 August 2017

Nicholas T Seyfried

10

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19 August 2017

Allan I Levey

11

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19 August 2017

James J Lah

12

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19 August 2017

language of work or name

English

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publication date

1 December 2013

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19 August 2017

Journal of Neuroscience

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19 August 2017

33

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19 August 2017

49

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19 August 2017

19086-19098

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describes a project that uses

19 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3850036/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

6 September 2017

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Rho Kinase II Phosphorylation of the Lipoprotein Receptor LR11/SORLA Alters Amyloid-β Production

6 September 2017

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Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration

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The secretases: enzymes with therapeutic potential in Alzheimer disease

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Targeted disruption of ROCK1 causes insulin resistance in vivo.

6 September 2017

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Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.

6 September 2017

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A quantitative analysis of kinase inhibitor selectivity

6 September 2017

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A guided tour into subcellular colocalization analysis in light microscopy

6 September 2017

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Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme

6 September 2017

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Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

6 September 2017

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Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

6 September 2017

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Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

6 September 2017

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

6 September 2017

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The Alzheimer family of diseases: many etiologies, one pathogenesis?

6 September 2017

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ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

6 September 2017

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

6 September 2017

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Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals

6 September 2017

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

6 September 2017

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

6 September 2017

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A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

6 September 2017

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

6 September 2017

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Beta-amyloid precursor protein cleavage by a membrane-bound protease

6 September 2017

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

6 September 2017

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Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos

6 September 2017

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BACE is degraded via the lysosomal pathway

14 September 2017

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Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

14 September 2017

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Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

14 September 2017

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Generation of amyloid β protein from its precursor is sequence specific

14 September 2017

1 reference

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

28 September 2017

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The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

26 June 2018

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Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

26 June 2018

1 reference

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Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial

2 September 2018

1 reference

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APP processing is regulated by cytoplasmic phosphorylation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3850036

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3850036

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3850036

Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3850036

10.1523/JNEUROSCI.2508-13.2013

2 September 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

24305806

1 reference