IL-23 and Th17 cytokines in intestinal homeostasis (Q37349727)

19 August 2017

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title

IL-23 and Th17 cytokines in intestinal homeostasis (English)

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19 August 2017

K J Maloy

1

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19 August 2017

M C Kullberg

series ordinal

2

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19 August 2017

publication date

2 July 2008

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19 August 2017

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19 August 2017

volume

1

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19 August 2017

issue

5

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19 August 2017

page(s)

339-349

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Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

19 August 2017

cites work

1 reference

TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.

21 January 2018

1 reference

IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts

21 January 2018

1 reference

IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.

21 January 2018

1 reference

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

21 January 2018

1 reference

IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production

21 January 2018

1 reference

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5 T follicular helper cells.

21 January 2018

1 reference

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

21 January 2018

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IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells

21 January 2018

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IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response

21 January 2018

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IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression

21 January 2018

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Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21.

21 January 2018

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IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.

21 January 2018

1 reference

IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes

21 January 2018

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Microbial lipopeptides induce the production of IL-17 in Th cells.

21 January 2018

1 reference

Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection.

21 January 2018

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IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection

21 January 2018

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Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion

21 January 2018

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IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger

21 January 2018

1 reference

The fundamental basis of inflammatory bowel disease

21 January 2018

1 reference

7 January 2021

Unravelling the pathogenesis of inflammatory bowel disease

1 reference

7 January 2021

Inflammatory bowel disease: clinical aspects and established and evolving therapies

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7 January 2021

Cytokines as therapeutic targets: advances and limitations

1 reference

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

7 January 2021

Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

1 reference

7 January 2021

The immunological and genetic basis of inflammatory bowel disease

1 reference

7 January 2021

Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

7 January 2021

T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells

1 reference

7 January 2021

Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism

1 reference

7 January 2021

Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation

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7 January 2021

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

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7 January 2021

Anti-interleukin-12 antibody for active Crohn's disease

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7 January 2021

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

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7 January 2021

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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7 January 2021

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

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7 January 2021

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

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7 January 2021

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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7 January 2021

T(H)-17 cells in the circle of immunity and autoimmunity

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7 January 2021

IL-17 family cytokines and the expanding diversity of effector T cell lineages

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7 January 2021

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

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7 January 2021

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

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7 January 2021

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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7 January 2021

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

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7 January 2021

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

1 reference

7 January 2021

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

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7 January 2021

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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7 January 2021

IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease

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7 January 2021

Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

1 reference

7 January 2021

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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7 January 2021

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

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7 January 2021

Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells

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7 January 2021

The IL23 axis plays a key role in the pathogenesis of IBD.

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7 January 2021

NOD2 and Crohn's disease: loss or gain of function?

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7 January 2021

Signalling pathways and molecular interactions of NOD1 and NOD2

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7 January 2021

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

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7 January 2021

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

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7 January 2021

A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis

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7 January 2021

IL-23 promotes tumour incidence and growth

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7 January 2021

How microorganisms tip the balance between interleukin-12 family members

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7 January 2021

Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells

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7 January 2021

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

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7 January 2021

Essential roles of c-Rel in TLR-induced IL-23 p19 gene expression in dendritic cells

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7 January 2021

Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

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7 January 2021

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

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7 January 2021

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

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7 January 2021

Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway

1 reference

7 January 2021

Nod-like proteins in immunity, inflammation and disease

1 reference

7 January 2021

Intracellular NOD-like receptors in host defense and disease

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7 January 2021

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 T helper cells

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7 January 2021

Transforming growth factor-beta induces development of the T(H)17 lineage

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7 January 2021

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses

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7 January 2021

CD4 CD25 T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

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7 January 2021

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

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7 January 2021

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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7 January 2021

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

1 reference

7 January 2021

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4( ) TH1-like responses

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7 January 2021

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4 T cells

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7 January 2021

Th17 cells and mucosal host defense

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7 January 2021

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

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7 January 2021

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense

1 reference

7 January 2021

IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection

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7 January 2021

IL-23 and IL-17 in the establishment of protective pulmonary CD4 T cell responses after vaccination and during Mycobacterium tuberculosis challenge

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7 January 2021

Th17 cell differentiation: the long and winding road

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7 January 2021

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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7 January 2021

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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7 January 2021

Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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7 January 2021

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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7 January 2021

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

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7 January 2021

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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7 January 2021

Development, cytokine profile and function of human interleukin 17-producing helper T cells

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7 January 2021

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology

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7 January 2021

Increased expression of interleukin 17 in inflammatory bowel disease

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7 January 2021

Porphyria cutanea tarda as a predictor of poor response to interferon alfa therapy in chronic hepatitis C.

1 reference

7 January 2021

The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis

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7 January 2021

Phenotypic and functional features of human Th17 cells

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7 January 2021

Interleukin-17 family members and inflammation

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7 January 2021

Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice

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7 January 2021

Claudins regulate the intestinal barrier in response to immune mediators

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7 January 2021

Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/autocrine loop

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7 January 2021

Regulation of inflammatory responses by IL-17F

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7 January 2021

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

1 reference

7 January 2021

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

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7 January 2021

CD4 T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4 T cells

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7 January 2021

Phenotypically distinct subsets of CD4 T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

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7 January 2021

Blocking of IL-6 signaling pathway prevents CD4 T cell-mediated colitis in a T(h)17-independent manner

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7 January 2021

Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

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7 January 2021

Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease

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7 January 2021

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

1 reference

7 January 2021

Interleukin 21: a cytokine/cytokine receptor system that has come of age

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7 January 2021

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

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7 January 2021

Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen

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7 January 2021

Regulation of gut inflammation and th17 cell response by interleukin-21.

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7 January 2021

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

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7 January 2021

IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.

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7 January 2021

A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells

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7 January 2021

Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.

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7 January 2021

Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis

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7 January 2021

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells

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7 January 2021

The IL-21 receptor augments Th2 effector function and alternative macrophage activation

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7 January 2021

Toll pathway-dependent blockade of CD4 CD25 T cell-mediated suppression by dendritic cells

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7 January 2021

IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells

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7 January 2021

IL-21 Counteracts the Regulatory T Cell-Mediated Suppression of Human CD4 T Lymphocytes

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7 January 2021

Interleukin-10 and related cytokines and receptors

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7 January 2021

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

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7 January 2021

Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

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7 January 2021

Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor

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7 January 2021

IL-22 increases the innate immunity of tissues

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7 January 2021

Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells.

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7 January 2021

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

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7 January 2021

Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts

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7 January 2021

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

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7 January 2021

Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease

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7 January 2021

Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status

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7 January 2021

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

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7 January 2021

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

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7 January 2021

Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation

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7 January 2021

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

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7 January 2021

Cytokine signaling modules in inflammatory responses

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7 January 2021

Conversion of peripheral CD4 CD25- naive T cells to CD4 CD25 regulatory T cells by TGF-beta induction of transcription factor Foxp3

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7 January 2021

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4 CD25 regulatory T cells

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7 January 2021

T cells that cannot respond to TGF-beta escape control by CD4( )CD25( ) regulatory T cells

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7 January 2021

Transforming growth factor-beta regulation of immune responses

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7 January 2021

Cutting edge: regulatory T cells induce CD4 CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

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7 January 2021

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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7 January 2021

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

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7 January 2021

Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

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7 January 2021

IL-6-dependent spontaneous proliferation is required for the induction of colitogenic IL-17-producing CD8 T cells

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7 January 2021

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

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7 January 2021

Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17

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7 January 2021

A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.

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7 January 2021

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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7 January 2021

Expression of interleukin-17F in a mouse model of allergic asthma

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7 January 2021

An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment

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7 January 2021

Identification of an interleukin 17F/17A heterodimer in activated human CD4 T cells

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7 January 2021

A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

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7 January 2021

Expression and regulation of IL-22 in the IL-17-producing CD4 T lymphocytes

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7 January 2021

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

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31 May 2024

https://opencitations.net/index/api/v1/citations/10.1172/JCI33194

Identifiers

DOI

10.1038/MI.2008.28

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Dimensions Publication ID

19 August 2017

1012083313

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