Molecular chaperones in pathogen virulence: emerging new targets for therapy. (Q37343873)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19064253 AND SRC:MED&resulttype=core&format=json

18 January 2020

review article

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title

Molecular chaperones in pathogen virulence: emerging new targets for therapy (English)

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18 January 2020

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2

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18 January 2020

1

Len Neckers

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18 January 2020

publication date

1 December 2008

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18 January 2020

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18 January 2020

volume

4

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18 January 2020

issue

6

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18 January 2020

page(s)

519-527

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Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones

18 January 2020

cites work

1 reference

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Systems analysis of chaperone networks in the malarial parasite Plasmodium falciparum

6 September 2017

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The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions.

6 September 2017

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Evolution of microbial virulence: the benefits of stress

6 September 2017

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Chaperoning a cellular upheaval in malaria: heat shock proteins in Plasmodium falciparum.

6 September 2017

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Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

6 September 2017

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

6 September 2017

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Spontaneous recovery of pathogenicity by Leishmania major hsp100-/- alters the immune response in mice

6 September 2017

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Genetic architecture of Hsp90-dependent drug resistance

6 September 2017

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PfPKB, a protein kinase B-like enzyme from Plasmodium falciparum: II. Identification of calcium/calmodulin as its upstream activator and dissection of a novel signaling pathway

6 September 2017

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Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection

6 September 2017

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Bacterial adhesion and entry into host cells

6 September 2017

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Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

6 September 2017

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ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity

6 September 2017

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Gene expression in Porphyromonas gingivalis after contact with human epithelial cells

6 September 2017

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The DnaK/DnaJ chaperone machinery of Salmonella enterica serovar Typhimurium is essential for invasion of epithelial cells and survival within macrophages, leading to systemic infection

6 September 2017

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Molecular cloning of the 82-kDa heat shock protein (HSP90) of Toxoplasma gondii associated with the entry into and growth in host cells

6 September 2017

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Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast

6 September 2017

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Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence

6 September 2017

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Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

6 September 2017

1 reference

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Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans

6 September 2017

1 reference

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Development of an interleukin-12-deficient mouse model that is permissive for colonization by a motile KE26695 strain of Helicobacter pylori

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Inhibition of HSP90 in Trypanosoma cruzi induces a stress response but no stage differentiation

6 September 2017

1 reference

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T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis

6 September 2017

1 reference

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

6 September 2017

1 reference

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Molecular chaperone Hsp90 is important for vaccinia virus growth in cells

6 September 2017

1 reference

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Heat shock protein 90 homeostasis controls stage differentiation in Leishmania donovani

6 September 2017

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The virus-chaperone connection

6 September 2017

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The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological media

6 September 2017

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ClpC ATPase is required for cell adhesion and invasion of Listeria monocytogenes

6 September 2017

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Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

6 September 2017

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A novel role for 100 kD heat shock proteins in the parasite Leishmania donovani

6 September 2017

1 reference

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Hsp90 as a capacitor for morphological evolution

6 September 2017

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Characterization of the thermal stress response of Campylobacter jejuni

6 September 2017

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Enhanced levels of Staphylococcus aureus stress protein GroEL and DnaK homologs early in infection of human epithelial cells

6 September 2017

1 reference

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The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Regulation of the dnaK operon of Streptomyces coelicolor A3(2) is governed by HspR, an autoregulatory repressor protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Leishmania Major Hsp100 Is Required Chiefly in the Mammalian Stage of the Parasite

6 September 2017

1 reference

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

6 September 2017

1 reference

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Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperones in the endoplasmic reticulum

6 September 2017

1 reference

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Cold stress proteins induced in Listeria monocytogenes in response to temperature downshock and growth at low temperatures

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Folding and oligomerization of influenza hemagglutinin in the ER and the intermediate compartment.

6 September 2017

1 reference

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Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs

6 September 2017

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Homologous plant and bacterial proteins chaperone oligomeric protein assembly

6 September 2017

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Subcellular localization and cytotoxic activity of the GroEL-like protein isolated from Actinobacillus actinomycetemcomitans.

6 September 2017

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Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses

14 September 2017

1 reference

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Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice

14 September 2017

1 reference

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Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef-mediated enhancement of viral gene expression and replication

14 September 2017

1 reference

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Glycosphingolipid-binding protein of Borrelia burgdorferi sensu lato

14 September 2017

1 reference

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Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide

14 September 2017

1 reference

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Hsp90-mediated folding of the lymphoid cell kinase p56lck

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Distinct physiological states of Plasmodium falciparum in malaria-infected patients

2 September 2018

1 reference

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Three-dimensional structure of heat shock protein 90 from Plasmodium falciparum: molecular modelling approach to rational drug design against malaria.

2 September 2018

1 reference

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A proteomics screen implicates HSP83 and a small kinetoplastid calpain-related protein in drug resistance in Leishmania donovani clinical field isolates by modulating drug-induced programmed cell death.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

Hsp90 is essential in the filarial nematode Brugia pahangi

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2752846

HspR is a global negative regulator of heat shock gene expression in Deinococcus radiodurans.

2 September 2018

1 reference

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Planning for epidemics--the lessons of SARS.

2 September 2018

1 reference

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Global regulation of virulence and the stress response by CsrA in the highly adapted human gastric pathogen Helicobacter pylori.

2 September 2018

1 reference

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Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors

2 September 2018

1 reference

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Post-translational modification of heat-shock protein 90: impact on chaperone function

2 September 2018

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12 December 2020

Participation of the molecular chaperone DnaK in intracellular growth of Brucella suis within U937-derived phagocytes

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12 December 2020

The description and antibiotic production of Streptomyces hygroscopicus var. Geldanus

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12 December 2020

Leishmania braziliensis panamensis: increased infectivity resulting from heat shock

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12 December 2020

Interaction of the Mr = 90,000 heat shock protein with the steroid-binding domain of the glucocorticoid receptor

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12 December 2020

A virulence factor of Helicobacter pylori: role of heat shock protein in mucosal inflammation after H. pylori infection

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12 December 2020

10.1016/J.CHOM.2008.10.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19064253 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19064253 AND SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

19064253

1 reference