Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms (Q37336104)

19 August 2017

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Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms (English)

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19 August 2017

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38

Philippe Froguel

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Eleftheria Zeggini

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Eleftheria Zeggini

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19 August 2017

Han Chen

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Jennifer Elizabeth Below

Jennifer E Below

23

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Loic Yengo

Loic Yengo

22

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Anubha Mahajan

Anubha Mahajan

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Mark Seielstad

Mark Seielstad

34

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Josée Dupuis

Josee Dupuis

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E. Shyong Tai

E Shyong Tai

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Karen L Mohlke

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Karen L Mohlke

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19 August 2017

Mark I McCarthy

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Gonçalo Abecasis

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Gonçalo Abecasis

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Michael Boehnke

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Danish Saleheen

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James B Meigs

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John Blangero

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Nancy J Cox

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David Altshuler

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Momoko Horikoshi

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Jaspal S Kooner

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Graeme I Bell

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James G Wilson

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Andrew P Morris

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Teresa Ferreira

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Lorenzo Pasquali

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Steven Wiltshire

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Jeroen R Huyghe

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Jennifer L Asimit

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Adam E Locke

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Neil R Robertson

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Xu Wang

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Xueling Sim

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Hayato Fujita

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Kazuo Hara

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Robin Young

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Weihua Zhang

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Sungkyoung Choi

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Ismeet Kaur

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Fumihiko Takeuchi

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Pierre Fontanillas

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Dorothée Thuillier

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Claudia H T Tam

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19 August 2017

Ying Wu

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Noél P Burtt

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Ravindranath Duggirala

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Jose C Florez

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Craig L Hanis

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Gil Atzmon

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Juliana C N Chan

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Ronald C W Ma

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Dwaipayan Bharadwaj

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Yoon Shin Cho

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19 August 2017

Taesung Park

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John C Chambers

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Takashi Kadowaki

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Jorge Ferrer

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Norihiro Kato

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19 August 2017

Yik Ying Teo

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19 August 2017

T2D-GENES Consortium

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19 August 2017

23 February 2016

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19 August 2017

Human Molecular Genetics

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2070-2081

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TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

19 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Quality control and conduct of genome-wide association meta-analyses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

CRISPR-Cas systems for editing, regulating and targeting genomes

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

An integrated map of genetic variation from 1,092 human genomes

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Bayesian refinement of association signals for 14 loci in 3 common diseases

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

An integrated encyclopedia of DNA elements in the human genome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Efficiency of trans-ethnic genome-wide meta-analysis and fine-mapping

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

GWAMA: software for genome-wide association meta-analysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Genome-wide association studies in diverse populations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

BEDTools: a flexible suite of utilities for comparing genomic features

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Leveraging genetic variability across populations for the identification of causal variants.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

A flexible and accurate genotype imputation method for the next generation of genome-wide association studies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Genome-wide association studies: implications for multiethnic samples

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

A second generation human haplotype map of over 3.1 million SNPs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Heterogeneity in meta-analyses of genome-wide association investigations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Transcriptional networks controlling pancreatic development and beta cell function.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

A transcription factor regulatory circuit in differentiated pancreatic cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Voltage-gated K channel KCNQ1 regulates insulin secretion in MIN6 β-cell line.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Transethnic meta-analysis of genomewide association studies

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5062576

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

2 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093/HMG/DDW048

21 January 2018

Identifiers

DOI

10.1093/HMG/DDW048

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

26911676

1 reference