Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus (Q37280337)

19 August 2017

Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus (English)

1 reference

19 August 2017

0 references

1 reference

0 references

7

Justin Hanes

1 reference

19 August 2017

Laura M Ensign

1

1 reference

19 August 2017

Benjamin C Tang

2

1 reference

19 August 2017

Ying-Ying Wang

3

1 reference

19 August 2017

Terence A Tse

4

1 reference

19 August 2017

Timothy Hoen

5

1 reference

19 August 2017

Richard Cone

6

1 reference

19 August 2017

language of work or name

English

0 references

publication date

1 June 2012

1 reference

Science Translational Medicine

19 August 2017

1 reference

19 August 2017

4

1 reference

19 August 2017

138

1 reference

19 August 2017

138ra79

1 reference

describes a project that uses

19 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3817739/fullTextXML

inferred from PubMed Central ID database lookup

cites work

In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

The last decade of microbicide clinical trials in Africa: from hypothesis to facts

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Nanoparticle-based vaginal drug delivery systems for HIV prevention

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Human immunodeficiency virus type 1 is trapped by acidic but not by neutralized human cervicovaginal mucus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Estradiol-induced vaginal mucus inhibits antigen penetration and CD8( ) T cell priming in response to intravaginal immunization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Biomarkers of cervicovaginal inflammation for the assessment of microbicide safety

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Topical microbicides to prevent HIV: clinical drug development challenges

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

A review of current intravaginal drug delivery approaches employed for the prophylaxis of HIV/AIDS and prevention of sexually transmitted infections

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Dawn of non-nucleoside inhibitor-based anti-HIV microbicides

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Real-time multiple-particle tracking: applications to drug and gene delivery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Why consider vaginal drug administration?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

The role of chemotherapy in the management of carcinoma of the cervix

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Cornification of the human vaginal epithelium.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Progesterone increases susceptibility and decreases immune responses to genital herpes infection

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Microbicide efficacy and toxicity tests in a mouse model for vaginal transmission of Chlamydia trachomatis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

The exfoliating cervico-vaginal surface. II. Scanning electron microscopical studies during the estrous cycle in mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

A morphologist's approach to the vagina--age-related changes and estrogen sensitivity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Tests of vaginal microbicides in the mouse genital herpes model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Effective vaginal DNA delivery with high transfection efficiency is a good system for induction of higher local vaginal immune responses

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Distribution of a vaginal gel (Invisible Condom) before, during and after simulated sexual intercourse and its persistence when delivered by two different vaginal applicators: a magnetic resonance imaging study

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Vaginal distribution of Replens and K-Y Jelly using three imaging techniques

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

A quantitative method for assessing stages of the rat estrous cycle

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Retention and distribution of two 99mTc-DTPA labelled vaginal dosage forms

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Influence of hormonal contraceptives on the immune cells and thickness of human vaginal epithelium

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Isotretinoin for low-grade cervical dysplasia in human immunodeficiency virus-infected women

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Properties of a new, long-lasting vaginal delivery system (LASRS) for contraceptive and antimicrobial agents

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Acyclovir treatment of experimental genital herpes simplex virus infections

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3817739

Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL)

3 September 2018

1 reference

12 December 2020

In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials

1 reference

12 December 2020

DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge

1 reference

12 December 2020

Histochemical localization of vaginal oxidative enzymes and mucins in rats treated with estradiol and progesterone

1 reference

12 December 2020

Determining the Stage of the Estrous Cycle in the Mouse by the Appearance of the Vagina

1 reference

12 December 2020

10.1126/SCITRANSLMED.3003453

Identifiers

DOI

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

22700955

1 reference