Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. (Q37275902)

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29 January 2020

title

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease (English)

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4

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author name string

Xiao Chen

1

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29 January 2020

Rupali Das

2

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29 January 2020

Richard Komorowski

3

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29 January 2020

Martin J Hessner

5

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29 January 2020

Masahiko Mihara

6

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29 January 2020

William R Drobyski

7

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language of work or name

English

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publication date

2 June 2009

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29 January 2020

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volume

114

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issue

4

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page(s)

891-900

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Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease

29 January 2020

cites work

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Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease

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Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

6 September 2017

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6 September 2017

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Reduced frequency of FOXP3 CD4 CD25 regulatory T cells in patients with chronic graft-versus-host disease

6 September 2017

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Human T regulatory cells can use the perforin pathway to cause autologous target cell death

6 September 2017

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4 CD25- T cells through Foxp3 induction and down-regulation of Smad7

6 September 2017

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CD4( )CD25( ) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

6 September 2017

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6 September 2017

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6 September 2017

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B7/CD28 costimulation is essential for the homeostasis of the CD4 CD25 immunoregulatory T cells that control autoimmune diabetes

6 September 2017

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6 September 2017

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14 September 2017

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28 September 2017

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26 June 2018

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26 June 2018

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In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation.

3 September 2018

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Mucosal FOXP3 regulatory T cells are numerically deficient in acute and chronic GvHD.

3 September 2018

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TGF-beta induces Foxp3 T-regulatory cells from CD4 CD25 - precursors

3 September 2018

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3 September 2018

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Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

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3 September 2018

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Selective survival of naturally occurring human CD4 CD25 Foxp3 regulatory T cells cultured with rapamycin

3 September 2018

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Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease

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Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Acute graft-versus-host disease does not require alloantigen expression on host epithelium

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10.1182/BLOOD-2009-01-197178

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19491393 AND SRC:MED&resulttype=core&format=json

29 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19491393 AND SRC:MED&resulttype=core&format=json

29 January 2020

PubMed publication ID

19491393

1 reference