The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer (Q37271741)

19 August 2017

The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer (English)

1 reference

19 August 2017

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1 reference

Heike Döppler

1

1 reference

19 August 2017

Richard Panayiotou

2

1 reference

19 August 2017

Elizabeth M Reid

3

1 reference

19 August 2017

Willibroad Maimo

4

1 reference

19 August 2017

Ligia Bastea

5

1 reference

19 August 2017

Peter Storz

6

1 reference

19 August 2017

language of work or name

English

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publication date

21 September 2016

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19 August 2017

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19 August 2017

6

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19 August 2017

33758

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Creative Commons Attribution 4.0 International

19 August 2017

start time

21 September 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

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Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

6 September 2017

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Critical role of NF-κB in pancreatic cancer

6 September 2017

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Kras as a key oncogene and therapeutic target in pancreatic cancer

6 September 2017

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Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis.

6 September 2017

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GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB.

6 September 2017

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Emodin sensitizes the gemcitabine-resistant cell line Bxpc-3/Gem to gemcitabine via downregulation of NF-κB and its regulated targets

6 September 2017

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Double inhibition of NF-κB and XIAP via RNAi enhances the sensitivity of pancreatic cancer cells to gemcitabine

6 September 2017

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Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity

6 September 2017

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EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma

6 September 2017

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EGF receptor is required for KRAS-induced pancreatic tumorigenesis

6 September 2017

1 reference

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An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.

6 September 2017

1 reference

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KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.

6 September 2017

1 reference

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Differential expression of PKD1 and PKD2 in gastric cancer and analysis of PKD1 and PKD2 function in the model system

6 September 2017

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Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

6 September 2017

1 reference

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Role of protein kinase D signaling in pancreatic cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo

6 September 2017

1 reference

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Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells

6 September 2017

1 reference

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Nuclear factor-kappaB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

NIK is involved in constitutive activation of the alternative NF-kappaB pathway and proliferation of pancreatic cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Protein kinase d regulates cell death pathways in experimental pancreatitis.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5030668

The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27649783

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PKCμ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27649783

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP33758

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

27649783

1 reference