Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. (Q37270464)

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14 January 2020

review article

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title

Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests (English)

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14 January 2020

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14 January 2020

Ralph Martins

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14 January 2020

author name string

K A Bates

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14 January 2020

Q-X Li

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D Ames

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14 January 2020

P Hudson

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14 January 2020

C L Masters

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language of work or name

English

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publication date

16 September 2008

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14 January 2020

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volume

14

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issue

5

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14 January 2020

page(s)

469-486

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

14 January 2020

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CSF Abeta 42 levels correlate with amyloid-neuropathology in a population-based autopsy study

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7 January 2021

Amyloid beta-peptide in cerebrospinal fluid in individuals with the Swedish Alzheimer amyloid precursor protein mutation.

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7 January 2021

Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

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7 January 2021

High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype.

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7 January 2021

CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment

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7 January 2021

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A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

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7 January 2021

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7 January 2021

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Purification and characterization of brain clusterin

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7 January 2021

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7 January 2021

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7 January 2021

Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding.

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7 January 2021

Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates beta-amyloid protein activation of complement in vitro

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7 January 2021

Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

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7 January 2021

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease

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7 January 2021

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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7 January 2021

Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.

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7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition

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7 January 2021

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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7 January 2021

Blood-borne factors inhibit Alzheimer's beta-amyloid fibril formation in vitro

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7 January 2021

Alpha2-macroglobulin deletion polymorphism and plasma levels in late onset Alzheimer's disease.

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7 January 2021

Alpha-2 macroglobulin gene and Alzheimer disease.

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7 January 2021

Alpha2 macroglobulin and the risk of Alzheimer's disease.

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7 January 2021

The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis

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7 January 2021

An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.

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7 January 2021

Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK.

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7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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7 January 2021

Increased plasma concentration of serum amyloid P component in centenarians with impaired cognitive performance

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7 January 2021

Assessment of cerebrospinal fluid levels of serum amyloid P component in patients with Alzheimer's disease.

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7 January 2021

APOE-epsilon4 and APOE -491A polymorphisms in individuals with subjective memory loss.

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7 January 2021

Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment.

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7 January 2021

Plasma alpha1-antichymotrypsin in Alzheimer's disease; relationships with APOE genotypes

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7 January 2021

Aggregation of amyloid beta-protein as function of age and apolipoprotein E in normal and Alzheimer's serum.

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7 January 2021

Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

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7 January 2021

Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions

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7 January 2021

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

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Serum insulin-like growth factor I regulates brain amyloid-beta levels

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7 January 2021

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

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7 January 2021

Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis.

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7 January 2021

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

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7 January 2021

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

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7 January 2021

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

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7 January 2021

Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease

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7 January 2021

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

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Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

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7 January 2021

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease

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7 January 2021

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7 January 2021

Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor

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7 January 2021

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

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7 January 2021

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

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7 January 2021

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

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Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

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7 January 2021

Insulin increases CSF Abeta42 levels in normal older adults

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7 January 2021

The role of gonadotropins in Alzheimer's disease: potential neurodegenerative mechanisms.

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7 January 2021

Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin

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7 January 2021

Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype

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7 January 2021

Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose.

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7 January 2021

Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype.

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7 January 2021

Memory improvement following induced hyperinsulinemia in Alzheimer's disease.

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7 January 2021

Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosis

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7 January 2021

Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation

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7 January 2021

Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels

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7 January 2021

Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease.

1 reference

7 January 2021

The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43).

1 reference

7 January 2021

Amyloid beta protein in plasma from patients with sporadic Alzheimer's disease.

1 reference

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

7 January 2021

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

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7 January 2021

Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma

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7 January 2021

Biochemical diagnostic markers to detect early Alzheimer's disease

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7 January 2021

Familial Alzheimer disease: decreases in CSF Abeta42 levels precede cognitive decline.

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7 January 2021

Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia.

1 reference

7 January 2021

Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample.

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7 January 2021

Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau.

1 reference

7 January 2021

Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice

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7 January 2021

Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.

1 reference

7 January 2021

CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment.

1 reference

7 January 2021

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study.

1 reference

7 January 2021

Identifiers

DOI

10.1038/MP.2008.96

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18794889 AND SRC:MED&resulttype=core&format=json

14 January 2020

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