The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey (Q37270420)

19 August 2017

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title

The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey (English)

1 reference

19 August 2017

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C B Knobbe

1

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19 August 2017

V Lapin

series ordinal

2

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19 August 2017

A Suzuki

series ordinal

3

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19 August 2017

T W Mak

series ordinal

4

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19 August 2017

language of work or name

English

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publication date

1 September 2008

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19 August 2017

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19 August 2017

volume

27

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19 August 2017

issue

41

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19 August 2017

page(s)

5398-5415

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Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Somatic mutation of PTEN in bladder carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN function in mammalian cell size regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

S6k1 is not required for Pten-deficient neuronal hypertrophy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pathological and molecular aspects of prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Impaired Fas response and autoimmunity in Pten /- mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten is essential for embryonic development and tumour suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Genetic testing in autism: how much is enough?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN-deficient intestinal stem cells initiate intestinal polyposis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Expanding role of AMPK in endocrinology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Effective clearance of intracellularLeishmania majorin vivo requires Pten in macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten regulates neuronal arborization and social interaction in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Prostate specific expression of Cre recombinase in transgenic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Molecular biology and the staging of prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

AID is required for germinal center-derived lymphomagenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Cell-specific roles of glucokinase in glucose homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Inducible gene knockouts in the small intestinal and colonic epithelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/ mouse: roles of osteopontin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Role of PTEN/PI3K pathway in endothelial cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN expression is maintained in sporadic colorectal tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten dose dictates cancer progression in the prostate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN gene loss, but not mutation, in benign and malignant phaeochromocytomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pathways to melanoma development: lessons from the mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Muscle-specific Pten deletion protects against insulin resistance and diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038/ONC.2008.238

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.238

1 reference

19 August 2017

1 reference