Conserved functions of the pRB and E2F families (Q37249375)

19 August 2017

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title

Conserved functions of the pRB and E2F families (English)

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19 August 2017

author

Sander van den Heuvel

series ordinal

1

object named as

Sander van den Heuvel

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author name string

Nicholas J Dyson

series ordinal

2

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19 August 2017

publication date

1 September 2008

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Nature Reviews Molecular Cell Biology

19 August 2017

published in

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19 August 2017

volume

9

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19 August 2017

issue

9

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19 August 2017

page(s)

713-724

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Functional properties of a Drosophila homolog of the E2F1 gene

19 August 2017

cites work

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Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.

21 January 2018

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Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes

21 January 2018

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The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development

21 January 2018

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Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

21 January 2018

1 reference

LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes

21 January 2018

1 reference

The retinoblastoma protein and cell cycle control

21 January 2018

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Retinoblastoma protein partners

31 March 2020

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How the other half lives, the amino‐terminal domain of the retinoblastoma tumor suppressor protein

31 March 2020

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The retinoblastoma tumor-suppressor gene, the exception that proves the rule

31 March 2020

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Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

31 March 2020

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The E2F transcription factor is a cellular target for the RB protein

31 March 2020

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The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

31 March 2020

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A new component of the transcription factor DRTF1/E2F.

31 March 2020

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DNA-binding and trans-activation properties of Drosophila E2F and DP proteins

31 March 2020

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dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster

31 March 2020

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RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

31 March 2020

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Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2

31 March 2020

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The transcription factor E2F is required for S phase during Drosophila embryogenesis

31 March 2020

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Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program

31 March 2020

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Coordination of growth and cell division in the Drosophila wing

31 March 2020

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The E2F1-3 transcription factors are essential for cellular proliferation.

31 March 2020

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Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing

31 March 2020

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The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis

31 March 2020

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The Drosophila cyclin D-Cdk4 complex promotes cellular growth

31 March 2020

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A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis

31 March 2020

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Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development

31 March 2020

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Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.

31 March 2020

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Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.

31 March 2020

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E2F-induced S phase requires cyclin E.

31 March 2020

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A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila.

31 March 2020

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Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

31 March 2020

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Repression of dMyc expression by Wingless promotes Rbf-induced G1 arrest in the presumptive Drosophila wing margin

31 March 2020

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Control of cell proliferation in the Drosophila eye by Notch signaling.

31 March 2020

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Functional antagonism between E2F family members

31 March 2020

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Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway

31 March 2020

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dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1.

31 March 2020

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Specific role of the SR protein splicing factor B52 in cell cycle control in Drosophila

31 March 2020

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G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression

31 March 2020

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The contribution of E2F-regulated transcription to Drosophila PCNA gene function.

31 March 2020

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dDP is needed for normal cell proliferation

31 March 2020

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Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells

31 March 2020

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dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development

31 March 2020

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The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling

31 March 2020

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lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

31 March 2020

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Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB).

31 March 2020

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Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles

31 March 2020

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The SynMuv genes of Caenorhabditis elegans in vulval development and beyond

31 March 2020

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Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans

31 March 2020

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A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling

31 March 2020

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SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans

31 March 2020

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A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.

31 March 2020

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lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans

31 March 2020

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Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis

31 March 2020

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Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans

31 March 2020

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MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans

31 March 2020

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The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans

31 March 2020

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Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.

31 March 2020

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Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans

31 March 2020

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MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.

31 March 2020

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Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

31 March 2020

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Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi

31 March 2020

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Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.

31 March 2020

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Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference

31 March 2020

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Transcriptional silencing of a transgene by RNAi in the soma of C. elegans

31 March 2020

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Functional genomic analysis of RNA interference in C. elegans

31 March 2020

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Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans

31 March 2020

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C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates

31 March 2020

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The RETINOBLASTOMA-RELATED Gene Regulates Stem Cell Maintenance in Arabidopsis Roots

31 March 2020

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lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans

31 March 2020

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The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.

31 March 2020

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lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development

31 March 2020

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gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans

31 March 2020

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lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.

31 March 2020

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XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans

31 March 2020

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Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

31 March 2020

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C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination

31 March 2020

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Extra-embryonic function of Rb is essential for embryonic development and viability

31 March 2020

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31 March 2020

E2F-1 induced apoptosis

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Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

31 March 2020

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Life and death decisions by the E2F transcription factors

31 March 2020

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Direct coupling of the cell cycle and cell death machinery by E2F.

31 March 2020

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Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

31 March 2020

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E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

31 March 2020

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Cell type-specific effects of Rb deletion in the murine retina.

31 March 2020

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Rb regulates proliferation and rod photoreceptor development in the mouse retina

31 March 2020

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Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma

31 March 2020

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31 March 2020

Tumor suppressor genes

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p53 and E2F-1 cooperate to mediate apoptosis

31 March 2020

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Cooperative tumorigenic effects of germline mutations in Rb and p53

31 March 2020

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Inactivation of the p53 pathway in retinoblastoma.

31 March 2020

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DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans

31 March 2020

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C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions

31 March 2020

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The E2F cell cycle regulator is required for Drosophila nurse cell DNA replication and apoptosis

31 March 2020

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Distinct Pathways Mediate UV-Induced Apoptosis in Drosophila Embryos

31 March 2020

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Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development

31 March 2020

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E2F and cell survival: context really is key.

31 March 2020

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Specificity in the activation and control of transcription factor E2F-dependent apoptosis

31 March 2020

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EGFR signaling inhibits E2F1-induced apoptosis in vivo: implications for cancer therapy.

31 March 2020

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An E2F1-dependent gene expression program that determines the balance between proliferation and cell death

31 March 2020

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Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo

31 March 2020

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ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.

31 March 2020

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DNA replication control through interaction of E2F-RB and the origin recognition complex

31 March 2020

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Regulation of DNA replication during Drosophila development

31 March 2020

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Drosophila chorion genes: cracking the eggshell's secrets

31 March 2020

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Chromatin regulates origin activity in Drosophila follicle cells

31 March 2020

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Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation.

31 March 2020

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Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.

31 March 2020

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Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication

31 March 2020

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Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

31 March 2020

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Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes

31 March 2020

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Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

31 March 2020

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Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex

31 March 2020

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

31 March 2020

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Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex

31 March 2020

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p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes

31 March 2020

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Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

31 March 2020

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A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression

31 March 2020

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LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes

31 March 2020

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L3MBTL1, a histone-methylation-dependent chromatin lock

31 March 2020

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RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3

31 March 2020

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Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability

31 March 2020

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Loss of Drosophila Myb interrupts the progression of chromosome condensation

31 March 2020

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Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF via the Myb-MuvB/dREAM complex

31 March 2020

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Cyclin D regulation of a sexually dimorphic asymmetric cell division

31 March 2020

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Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development

31 March 2020

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The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development

31 March 2020

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A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development

31 March 2020

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Crystal Structure of the Retinoblastoma Protein N Domain Provides Insight into Tumor Suppression, Ligand Interaction, and Holoprotein Architecture

31 March 2020

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The regulation of E2F by pRB-family proteins

31 March 2020

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Regulation of cell proliferation by the E2F transcription factors

31 March 2020

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Sibling rivalry in the E2F family

31 March 2020

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Pocket proteins and cell cycle control

31 March 2020

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The E2F transcriptional network: old acquaintances with new faces

31 March 2020

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Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?

31 March 2020

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Distinct developmental expression of Drosophila retinoblastoma factors.

31 March 2020

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Directing cell division during development

31 March 2020

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Developmental control of cell cycle regulators: a fly's perspective

31 March 2020

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The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string

31 March 2020

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Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis

31 March 2020

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Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila

31 March 2020

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PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

31 March 2020

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Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S.

31 March 2020

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Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes

31 March 2020

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The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans

31 March 2020

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The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans

31 March 2020

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C. elegans class B synthetic multivulva genes act in G(1) regulation

31 March 2020

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fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2469

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Dimensions Publication ID

19 August 2017

1009483120

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